{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:29:57Z","timestamp":1789694997336,"version":"4.0.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Controversies exist about posterior pituitary (PP) function in subjects with ectopic PP (EPP) and with cerebral midline defects and\/or their co-occurrence. We investigate water and electrolyte disturbances in patients at risk for PP dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The study was conducted in a single Pediatric Endocrinology Research Unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty-two subjects with childhood-onset GH deficiency were subdivided into five groups: normal magnetic resonance imaging (<jats:italic>n<\/jats:italic>=8, group 1); EPP (<jats:italic>n<\/jats:italic>=15, group 2); septo-optic dysplasia (SOD) with normal PP (<jats:italic>n<\/jats:italic>=4, group 3); EPP and SOD without (<jats:italic>n<\/jats:italic>=7, group 4), and with additional midline brain abnormalities (<jats:italic>n<\/jats:italic>=8, group 5). At a mean age of 16.0\u00b11.1 years, they underwent a 120\u200amin i.v. infusion with hypertonic 5% saline and evaluation of plasma osmolality (Posm), arginine vasopressin (AVP), thirst score (in groups 1 and 2), and urinary osmolality were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean Posm and AVP significantly increased from baseline scores (284.7\u00b14.9\u200amosm\/kg and 0.6\u00b10.2\u200apmol\/l) to 120\u200amin after saline infusion (300.5\u00b18.0\u200amosm\/kg and 10.3\u00b13.3\u200apmol\/l,<jats:italic>P<\/jats:italic>&lt;0.0001). Group 5 showed higher mean Posm and lower mean AVP at all time points (<jats:italic>P<\/jats:italic>&lt;0.0001). Mean thirst score did not show a significantly different trend between the groups 1 and 2. Urine osmolality was above 750\u200amosm\/kg in all but seven patients after osmotic challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with midline brain abnormalities and EPP have defective osmoregulated AVP. Patients with EPP and congenital hypopituitarism have normal PP function.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-11-0437","type":"journal-article","created":{"date-parts":[[2011,7,13]],"date-time":"2011-07-13T01:52:44Z","timestamp":1310521964000},"page":"411-420","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":25,"title":["Posterior pituitary (PP) evaluation in patients with anterior pituitary defect associated with ectopic PP and septo-optic dysplasia"],"prefix":"10.1093","volume":"165","author":[{"given":"Andrea","family":"Secco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Elsa Maria","family":"Allegri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natascia","family":"di Iorgi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Napoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AnnaLisa","family":"Calcagno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Bertelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Olivieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Pala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Parodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Gastaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Maghnie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"1_34356571","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1159\/000207479","volume":"14","author":"di Iorgi","year":"2009","journal-title":"Endocrine development","ISSN":"https:\/\/id.crossref.org\/issn\/1421-7082","issn-type":"print"},{"issue":"5","key":"2_18399054","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/BF03345298","volume":"27","author":"Maghnie","year":"2004","journal-title":"Journal of endocrinological investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0391-4097","issn-type":"print"},{"key":"3_40537228","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1586\/17446651.1.1.1","volume":"1","year":"2006","journal-title":"EXPERT REVIEW OF ENDOCRINOLOGY METABOLISM"},{"issue":"3","key":"4_34457171","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/j.1365-2265.2009.03572.x","volume":"71","author":"Mehta","year":"2009","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"3","key":"5_14684085","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1542\/peds.93.3.409","volume":"93","author":"Triulzi","year":"1994","journal-title":"Pediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/0031-4005","issn-type":"print"},{"issue":"1","key":"6_10424422","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1046\/j.1365-2265.2000.01030.x","volume":"53","author":"Lukezic","year":"2000","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"4","key":"7_15465116","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1210\/jc.78.4.884","volume":"78","author":"Yagi","year":"1994","journal-title":"Journal of Clinical Endocrinology &amp; 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