{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:36:26Z","timestamp":1791326186398,"version":"4.3.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>\n                      Several studies demonstrated that obese children have higher TSH than normal-weight children. The polymorphism rs4704397 in the phosphodiesterase 8B (\n                      <jats:italic>PDE8B<\/jats:italic>\n                      ) gene showed an association with TSH.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      i) To assess the effect of\n                      <jats:italic>PDE8B<\/jats:italic>\n                      on TSH in obese children; ii) to dissect the role of obesity degree in modulating this association; and iii) to stratify the individual risk to show hyperthyrotropinaemia according to\n                      <jats:italic>PDE8B<\/jats:italic>\n                      genotype.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eight hundred and sixty-seven Italian obese children were investigated. Clinical data and thyroid hormones were evaluated and the\n                      <jats:italic>PDE8B<\/jats:italic>\n                      rs4704397 was genotyped.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>PDE8B<\/jats:italic>\n                      A\/A homozygous subjects showed higher TSH (\n                      <jats:italic>P<\/jats:italic>\n                      =0.0005) compared with A\/G or G\/G. No differences were found for peripheral thyroid hormones. Among A\/A children, 22% had hyperthyrotropinaemia, compared with 11.6% of heterozygotes and 10.8% of G\/G (\n                      <jats:italic>P<\/jats:italic>\n                      =0.0008). Consistently, A\/A had an odds ratio (OR) to show abnormal TSH level of 2.25 (\n                      <jats:italic>P<\/jats:italic>\n                      =0.0004). Body mass index (BMI) appeared correlated with TSH (\n                      <jats:italic>P<\/jats:italic>\n                      =0.0001), but the strength of the effect of\n                      <jats:italic>PDE8B<\/jats:italic>\n                      on TSH was independent of BMI (\n                      <jats:italic>P<\/jats:italic>\n                      =0.1).\n                    <\/jats:p>\n                    <jats:p>\n                      Children were subdivided into six groups according to obesity degree and genotypes.\n                      <jats:italic>PDE8B<\/jats:italic>\n                      A\/A with BMI SDS above 3 had the highest OR (OR 2.6,\n                      <jats:italic>P<\/jats:italic>\n                      =0.0015) to have hyperthyrotropinaemia, whereas G\/G with BMI SDS below 3 showed the lowest possibilities (OR 0.3,\n                      <jats:italic>P<\/jats:italic>\n                      =0.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      We have shown: i) in obese children,\n                      <jats:italic>PDE8B<\/jats:italic>\n                      is associated with TSH; ii) the interaction between adiposity and\n                      <jats:italic>PDE8B<\/jats:italic>\n                      on TSH is not synergistic, but follows an additive model; and iii) impact of this association in the stratification of individual risk to have hyperthyrotropinaemia.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/eje-11-0703","type":"journal-article","created":{"date-parts":[[2011,11,15]],"date-time":"2011-11-15T13:37:10Z","timestamp":1321364230000},"page":"255-260","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":13,"title":["Impact of phosphodiesterase 8B gene rs4704397 variation on thyroid homeostasis in childhood obesity"],"prefix":"10.1093","volume":"166","author":[{"given":"Anna","family":"Grandone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Perrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Cirillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Di Sessa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Maria","family":"Corona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Amato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Cresta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Miraglia del Giudice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"4","key":"1_39553932","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/MOP.0b013e328344c393","volume":"23","author":"Reinehr","year":"2011","journal-title":"Current opinion in pediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/1040-8703","issn-type":"print"},{"issue":"1","key":"2_10638490","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1159\/000063431","volume":"54","author":"Stichel","year":"2000","journal-title":"Hormone research","ISSN":"https:\/\/id.crossref.org\/issn\/0301-0163","issn-type":"print"},{"key":"3_41554882","first-page":"773","volume":"99","year":"2007","journal-title":"JOURNAL OF THE NATIONAL MEDICAL ASSIOCIATION"},{"issue":"8","key":"4_22077706","doi-asserted-by":"publisher","first-page":"3088","DOI":"10.1210\/jc.2006-0095","volume":"91","year":"2006","journal-title":"Journal of Clinical Endocrinology &amp; 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