{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:13:24Z","timestamp":1784819604924,"version":"3.55.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The mainstay of distinction between prepubertal girls and girls who are suspected of having central precocious puberty (CPP) is based on gonadotropin measurements after a GnRH stimulation test to evaluate hypothalamic\u2013pituitary\u2013gonadal axis maturity. The objective of this study was to determine whether a single basal gonadotropin measurement carries a useful predictive value in verifying or refuting the diagnosis of CPP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and methods<\/jats:title><jats:p>Basal serum LH and FSH were measured by a chemiluminescent immunometric assay in a cohort of girls who had been evaluated for CPP before and after GnRH stimulation test. Peak LH levels higher than 5\u200aIU\/l were considered a pubertal response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty girls with suspected breast development before 8 years of age were enrolled to the study, out of whom 42 had CPP.<\/jats:p><jats:p>Low basal serum LH (\u22640.1\u200aIU\/l) was sufficient to rule out the diagnosis of CPP in 94.7% of the 38 prepubertal girls; the sensitivity of basal LH levels for this purpose was only 64%. The basal FSH and the basal LH to FSH ratio achieved less efficient predictive value with 76 and 71% sensitivity and 73 and 86% specificity respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A single basal LH measurement may be adequate to confirm but not to refute the presence of CPP in most of the girls who are evaluated for early pubertal signs.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-11-0720","type":"journal-article","created":{"date-parts":[[2011,11,15]],"date-time":"2011-11-15T18:37:10Z","timestamp":1321382230000},"page":"295-299","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":91,"title":["The utility of basal serum LH in prediction of central precocious puberty in girls"],"prefix":"10.1093","volume":"166","author":[{"given":"Yehonatan","family":"Pasternak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Friger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neta","family":"Loewenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Haim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Hershkovitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"4","key":"1_6412170","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/S0889-8529(05)70108-0","volume":"28","author":"Lee","year":"1999","journal-title":"Endocrinology and metabolism clinics of North America","ISSN":"https:\/\/id.crossref.org\/issn\/0889-8529","issn-type":"print"},{"key":"3_31692284","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1515\/JPEM.2000.13.S1.709","volume":"13","year":"2000","journal-title":"The Journal of pediatric endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0334-018X","issn-type":"print"},{"issue":"1","key":"4_15937785","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0022-3476(95)70255-5","volume":"127","author":"Neely","year":"1995","journal-title":"The Journal of pediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3476","issn-type":"print"},{"issue":"2","key":"5_16899398","doi-asserted-by":"publisher","first-page":"e30","DOI":"10.1542\/peds.109.2.e30","volume":"109","author":"Bhatia","year":"2002","journal-title":"Pediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/0031-4005","issn-type":"print"},{"key":"6_41554895","doi-asserted-by":"crossref","first-page":"e1059","DOI":"10.1542\/peds.2008-1180","volume":"123","year":"2008","journal-title":"Pediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/0031-4005","issn-type":"print"},{"key":"7_33361490","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3","volume":"3","year":"1950","ISSN":"https:\/\/id.crossref.org\/issn\/1097-0142","issn-type":"print"},{"issue":"6","key":"8_29951175","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1111\/j.1442-200X.2007.02475.x","volume":"49","author":"Choi","year":"2007","journal-title":"Pediatrics international : official journal of the Japan Pediatric Society","ISSN":"https:\/\/id.crossref.org\/issn\/1328-8067","issn-type":"print"},{"key":"9_24660579","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1515\/JPEM.2000.13.S1.695","volume":"13","year":"2000","journal-title":"The Journal of pediatric endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0334-018X","issn-type":"print"},{"issue":"10","key":"10_10606082","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1515\/CCLM.2000.154","volume":"38","author":"Tello","year":"2000","journal-title":"Clinical chemistry and laboratory medicine : CCLM \/ FESCC","ISSN":"https:\/\/id.crossref.org\/issn\/1434-6621","issn-type":"print"},{"issue":"5","key":"11_39244770","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1210\/jc.2010-2745","volume":"96","year":"2011","journal-title":"Journal of Clinical Endocrinology &amp; 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