{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:31:32Z","timestamp":1774686692790,"version":"3.50.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Low birth weight (LBW) is common in the Indian population and may represent an important predisposing factor for type 2 diabetes (T2D) and the metabolic syndrome. Intensive metabolic examinations in ethnic LBW Asian Indians have been almost exclusively performed in immigrants living outside India. Therefore, we aimed to study the metabolic impact of being born with LBW in a rural non-migrant Indian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and methods<\/jats:title><jats:p>One hundred and seventeen non-migrant, young healthy men were recruited from a birth cohort in a rural part of south India. The subjects comprised 61 LBW and 56 normal birth weight (NBW) men, with NBW men acting as controls. Subjects underwent a hyperinsulinaemic euglycaemic clamp, i.v. and oral glucose tolerance tests and a dual-energy X-ray absorptiometry scan. The parents' anthropometric status and metabolic parameters were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Men with LBW were shorter (167\u00b16.4 vs 172\u00b16.0\u200acm,<jats:italic>P<\/jats:italic>&lt;0.0001), lighter (51.9\u00b19 vs 55.4\u00b17\u200akg,<jats:italic>P<\/jats:italic>=0.02) and had a reduced lean body mass (42.1\u00b15.4 vs 45.0\u00b14.5\u200akg,<jats:italic>P<\/jats:italic>=0.002) compared with NBW controls. After adjustment for height and weight, the LBW subjects had increased diastolic blood pressure (77\u00b16 vs 75\u00b16\u200ammHg,<jats:italic>P<\/jats:italic>=0.01). Five LBW subjects had impaired glucose tolerance.<jats:italic>In vivo<\/jats:italic>insulin secretion and peripheral insulin action were similar in both the groups. Mothers of the LBW subjects were 3\u200acm shorter than the control mothers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Only subtle features of the metabolic syndrome and changes in body composition among LBW rural Indians were found. Whether other factors such as urbanisation and ageing may unmask more severe metabolic abnormalities may require a long-term follow-up.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-11-0870","type":"journal-article","created":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T04:28:00Z","timestamp":1326774480000},"page":"647-655","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":46,"title":["Born with low birth weight in rural Southern India: what are the metabolic consequences 20 years later?"],"prefix":"10.1093","volume":"166","author":[{"given":"Nihal","family":"Thomas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise G","family":"Grunnet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pernille","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solomon","family":"Christopher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachaproleu","family":"Spurgeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercy","family":"Inbakumari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roshan","family":"Livingstone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reginald","family":"Alex","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkataraghava R","family":"Mohan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belavendra","family":"Antonisamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Finney S","family":"Geethanjali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajni","family":"Karol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Vaag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ib C","family":"Bygbjerg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"issue":"5","key":"1_18156246","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"issue":"3","key":"2_16947785","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0899-9007(01)00741-9","volume":"18","author":"Das","year":"2002","journal-title":"Nutrition (Burbank, Los Angeles County, Calif.)","ISSN":"https:\/\/id.crossref.org\/issn\/0899-9007","issn-type":"print"},{"issue":"1 Pt 1","key":"3_11092418","first-page":"1","volume":"59","author":"Yajnik","year":"2001","journal-title":"Nutrition reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0029-6643","issn-type":"print"},{"key":"4_42293765","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/sj.ijo.0802307","volume":"27","year":"2003","journal-title":"INTERNATIONAL JOURNAL OF OBESITY AND RELATED METABOLIC DISORDERS"},{"issue":"8","key":"5_18282528","doi-asserted-by":"publisher","first-page":"3965","DOI":"10.1210\/jc.2004-0087","volume":"89","author":"Raji","year":"2004","journal-title":"Journal of Clinical Endocrinology &amp; 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