{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:46:40Z","timestamp":1787237200208,"version":"build-2736575974"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>A 35-year-old oriental woman, who was 32 weeks pregnant, was hospitalized with suspected preeclampsia. Subsequently, she developed stupor and lethargia. Biochemical assessment showed severe hypercalcemia (21\u200amg\/dl) with undetectable parathyroid hormone (PTH) and markedly elevated PTH-related peptide (PTHrP) levels (26\u200apmol\/l, normal values &lt;1.1\u200apmol\/l). The patient was treated with i.v. fluid administration, which resulted in an unsatisfactory reduction in serum calcium. Therefore, a cesarean section was performed to deliver the baby. Serum calcium levels promptly normalized after delivery with undetectable PTHrP levels. She delivered a healthy infant only presenting with transient mild jaundice and slightly prolonged QT interval with serum calcium level of 7.8\u20138.4\u200amg\/dl (corrected for albumin levels). In the subsequent days, the patient developed a transient \u2018hungry bone\u2019 syndrome (calcium 6.7\u200amg\/dl, phosphorous 2.1\u200amg\/dl, and PTH 100.4\u200apg\/ml). In conclusion, this pregnant patient presented with PTHrP-associated hypercalcemia, presumably of placental origin. Delivery resulted in prompt reduction of serum calcium levels and a transient \u2018hungry bone\u2019 syndrome.<\/jats:p>","DOI":"10.1530\/eje-11-1050","type":"journal-article","created":{"date-parts":[[2012,1,13]],"date-time":"2012-01-13T01:02:39Z","timestamp":1326416559000},"page":"753-756","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":42,"title":["PTHrP-associated hypercalcemia of pregnancy resolved after delivery: a case report"],"prefix":"10.1093","volume":"166","author":[{"given":"Cristina","family":"Eller-Vainicher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela Wally","family":"Ossola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Beck-Peccoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Chiodini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"4","key":"3_13327643","first-page":"717","volume":"96","author":"Kaplan","year":"1984","journal-title":"Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0039-6060","issn-type":"print"},{"issue":"6","key":"4_9658125","first-page":"1028","volume":"110","author":"Kelly","year":"1991","journal-title":"Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0039-6060","issn-type":"print"},{"issue":"4","key":"5_9940432","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1007\/BF02599166","volume":"7","author":"Carella","year":"1992","journal-title":"Journal of general internal medicine : official journal of the Society for Research and Education in Primary Care Internal Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0884-8734","issn-type":"print"},{"issue":"6","key":"6_6285879","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/S0146-0005(98)80028-1","volume":"22","author":"Mestman","year":"1998","journal-title":"Seminars in perinatology","ISSN":"https:\/\/id.crossref.org\/issn\/0146-0005","issn-type":"print"},{"issue":"1","key":"7_10734708","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/S0002-9610(98)00302-X","volume":"177","author":"Kort","year":"1999","journal-title":"American journal of surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9610","issn-type":"print"},{"key":"8_42293808","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00006254-200206000-00022","volume":"57","year":"2002","journal-title":"OBSTETRICAL AND GYNECOLOGICAL SURVEY"},{"issue":"6","key":"9_31520202","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1507\/endocrj.K08E-092","volume":"55","author":"Sato","year":"2008","journal-title":"Endocrine journal","ISSN":"https:\/\/id.crossref.org\/issn\/0918-8959","issn-type":"print"},{"issue":"6","key":"10_5656102","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1210\/jcem-70-6-1559","volume":"70","author":"KIMURA","year":"1990","journal-title":"Journal of Clinical Endocrinology &amp; 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