{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:18:15Z","timestamp":1790180295145,"version":"4.1.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the relationship between vitamin D status in healthy women and cardiovascular outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and methods<\/jats:title><jats:p>Between 1990 and 1993, 2016 healthy, recently postmenopausal women were enrolled in the Danish Osteoporosis Prevention Study. Serum levels of 25-hydroxyvitamin D (25(OH)D, nmol\/l) were measured at baseline. Participants were followed for 16 years. The primary end point was a combination of death, heart failure, myocardial infarction (MI) and stroke. Vitamin D deficiency was defined as serum 25(OH)D&lt;50\u200anmol\/l. The primary end point was adjusted for other risk factors of adverse cardiovascular events (age, smoking, blood pressure, hip\u2013waist ratio, education and family history of MI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, mean age was 50 years and BMI 25. Women with vitamin D deficiency (<jats:italic>n<\/jats:italic>=788) had more cardiovascular risk factors than vitamin D-replete women (<jats:italic>n<\/jats:italic>=1225). Compared with vitamin D-replete women, women with low 25(OH)D levels had significantly higher BMI and triglycerides, lower HDL and hip\u2013waist ratio and less education. More were smokers among the vitamin D deficient (47 vs 38%). A primary end point was experienced by 118 (15%) with vitamin D deficiency and by 125 (10%) of the vitamin D replete. Hazard ratio (HR) was 1.49 (95% confidence interval: 1.16\u20131.92;<jats:italic>P<\/jats:italic>=0.002) in the vitamin D deficient. Adjusted HR was 1.32 (1.02\u20131.71;<jats:italic>P<\/jats:italic>=0.03). In total, 135 women died; of these, 65 (8%) were of the vitamin D deficient and 70 (6%) in the vitamin D-replete group; unadjusted HR was 1.44 (1.02\u20132.01;<jats:italic>P<\/jats:italic>=0.04) for vitamin D deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Healthy women with vitamin D deficiency have increased risk of adverse cardiovascular outcome.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-12-0283","type":"journal-article","created":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T05:53:21Z","timestamp":1344491601000},"page":"553-560","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":36,"title":["Vitamin D deficiency in postmenopausal, healthy women predicts increased cardiovascular events: a 16-year follow-up study"],"prefix":"10.1093","volume":"167","author":[{"given":"Louise Lind","family":"Schierbeck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Rejnmark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte Landbo","family":"Tofteng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lis","family":"Stilgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Eiken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Mosekilde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens-Erik Beck","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"3","key":"1_41210839","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.amjcard.2011.09.020","volume":"109","author":"Vacek","year":"2012","journal-title":"The American journal of cardiology","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9149","issn-type":"print"},{"issue":"12","key":"2_31295051","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1001\/archinte.168.12.1340","volume":"168","author":"Dobnig","year":"2008","journal-title":"Archives of Internal Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9926","issn-type":"print"},{"issue":"6","key":"3_18557077","doi-asserted-by":"crossref","first-page":"1678S","DOI":"10.1093\/ajcn\/80.6.1678S","volume":"80","author":"Holick","year":"2004","journal-title":"The American Journal of Clinical Nutrition","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9165","issn-type":"print"},{"issue":"11","key":"4_19503056","doi-asserted-by":"crossref","first-page":"2739S","DOI":"10.1093\/jn\/135.11.2739S","volume":"135","author":"Holick","year":"2005","journal-title":"The Journal of Nutrition","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3166","issn-type":"print"},{"issue":"24","key":"5_32709874","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1016\/j.jacc.2008.08.050","volume":"52","author":"Lee","year":"2008","journal-title":"Journal of the American College of Cardiology","ISSN":"https:\/\/id.crossref.org\/issn\/0735-1097","issn-type":"print"},{"issue":"10","key":"6_31646738","doi-asserted-by":"publisher","first-page":"3927","DOI":"10.1210\/jc.2008-0784","volume":"93","year":"2008","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"6","key":"7_39486486","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1093\/eurjhf\/hfr016","volume":"13","year":"2011","journal-title":"European Journal of Heart Failure","ISSN":"https:\/\/id.crossref.org\/issn\/1388-9842","issn-type":"print"},{"issue":"6","key":"8_32065538","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1097\/MCO.0b013e328312c33f","volume":"11","author":"Zittermann","year":"2008","journal-title":"Current opinion in clinical nutrition and metabolic care","ISSN":"https:\/\/id.crossref.org\/issn\/1363-1950","issn-type":"print"},{"issue":"24","key":"9_40125904","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1001\/jama.2011.881","volume":"305","author":"Shapses","year":"2011","journal-title":"JAMA","ISSN":"https:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"issue":"6","key":"10_39078643","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.amjcard.2010.12.001","volume":"107","author":"Anderson","year":"2011","journal-title":"The American journal of cardiology","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9149","issn-type":"print"},{"issue":"1","key":"11_39998432","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3945\/ajcn.110.010272","volume":"94","year":"2011","journal-title":"The American Journal of Clinical Nutrition","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9165","issn-type":"print"},{"issue":"3","key":"12_29023686","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1056\/NEJMra070553","volume":"357","author":"Holick","year":"2007","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"3","key":"13_18699767","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/j.1365-2265.2005.02226.x","volume":"62","author":"Mosekilde","year":"2005","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"key":"14_13685905","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1749-6632.1985.tb11793.x","volume":"453","author":"Holick","year":"1985","journal-title":"Annals of the New York Academy of Sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0077-8923","issn-type":"print"},{"issue":"1","key":"15_8023868","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3109\/00365517909104935","volume":"39","author":"Lund","year":"1979","journal-title":"Scandinavian journal of clinical and laboratory investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0036-5513","issn-type":"print"},{"key":"16_43637702","first-page":"207","volume":"31","year":"2000","ISSN":"https:\/\/id.crossref.org\/issn\/1873-4111","issn-type":"print"},{"issue":"3","key":"17_10902825","first-page":"263","volume":"46","author":"Andersen","year":"1999","journal-title":"Danish medical bulletin","ISSN":"https:\/\/id.crossref.org\/issn\/0907-8916","issn-type":"print"},{"issue":"9","key":"18_16541017","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1006\/cbir.1996.0081","volume":"20","author":"O'Connell","year":"1996","journal-title":"Cell biology international","ISSN":"https:\/\/id.crossref.org\/issn\/1065-6995","issn-type":"print"},{"issue":"12","key":"19_17952011","doi-asserted-by":"publisher","first-page":"5766","DOI":"10.1210\/jc.2003-030604","volume":"88","author":"Visser","year":"2003","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"20_18782302","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.mam.2005.01.005","volume":"26","author":"Montero-Odasso","year":"2005","journal-title":"Molecular aspects of medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0098-2997","issn-type":"print"},{"issue":"2","key":"21_17150454","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1172\/JCI200215219","volume":"110","author":"Li","year":"2002","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"issue":"2","key":"22_17466155","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/jcb.10343","volume":"88","author":"Li","year":"2003","journal-title":"Journal of cellular biochemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0730-2312","issn-type":"print"},{"issue":"17","key":"23_40833945","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1161\/CIRCULATIONAHA.111.032680","volume":"124","year":"2011","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"issue":"1","key":"24_38734186","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1161\/HYPERTENSIONAHA.110.160929","volume":"57","year":"2011","journal-title":"Hypertension","ISSN":"https:\/\/id.crossref.org\/issn\/0194-911X","issn-type":"print"},{"issue":"4","key":"25_21850286","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/ajcn\/83.4.754","volume":"83","author":"Schleithoff","year":"2006","journal-title":"The American Journal of Clinical Nutrition","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9165","issn-type":"print"},{"issue":"2","key":"27_40085120","doi-asserted-by":"publisher","first-page":"534","DOI":"10.3945\/ajcn.110.008763","volume":"94","year":"2011","journal-title":"The American Journal of Clinical Nutrition","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9165","issn-type":"print"},{"issue":"jul29_1","key":"28_37728691","doi-asserted-by":"publisher","first-page":"c3691","DOI":"10.1136\/bmj.c3691","volume":"341","year":"2010","journal-title":"BMJ","ISSN":"https:\/\/id.crossref.org\/issn\/0959-8138","issn-type":"print"},{"issue":"18","key":"29_40851099","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1001\/archinternmed.2011.445","volume":"171","author":"Mursu","year":"2011","journal-title":"Archives of Internal Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9926","issn-type":"print"},{"issue":"8","key":"30_42608721","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.1210\/jc.2011-3328","volume":"97","year":"2012","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"7","key":"31_40114666","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1210\/jc.2011-0398","volume":"96","year":"2011","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"16","key":"32_29320092","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1001\/archinte.167.16.1730","volume":"167","author":"Autier","year":"2007","journal-title":"Archives of Internal Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9926","issn-type":"print"},{"issue":"4","key":"34_30227690","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1161\/CIRCULATIONAHA.107.706127","volume":"117","year":"2008","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"issue":"2","key":"35_40207953","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.jacc.2011.02.051","volume":"58","author":"Al Mheid","year":"2011","journal-title":"Journal of the American College of Cardiology","ISSN":"https:\/\/id.crossref.org\/issn\/0735-1097","issn-type":"print"},{"issue":"10","key":"36_37669668","doi-asserted-by":"publisher","first-page":"4584","DOI":"10.1210\/jc.2010-0606","volume":"95","year":"2010","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"37_30554589","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/j.1464-5491.2007.02360.x","volume":"25","author":"Sugden","year":"2008","journal-title":"Diabetic medicine : a journal of the British Diabetic Association","ISSN":"https:\/\/id.crossref.org\/issn\/0742-3071","issn-type":"print"},{"issue":"7","key":"38_38162021","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.amjcard.2010.05.027","volume":"106","author":"Anderson","year":"2010","journal-title":"The American journal of cardiology","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9149","issn-type":"print"},{"issue":"3","key":"39_35344514","doi-asserted-by":"publisher","first-page":"e362","DOI":"10.1542\/peds.2009-0051","volume":"124","year":"2009","journal-title":"Pediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/0031-4005","issn-type":"print"},{"issue":"11","key":"41_31220746","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1001\/archinte.168.11.1174","volume":"168","author":"Giovannucci","year":"2008","journal-title":"Archives of Internal Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9926","issn-type":"print"},{"key":"42_43637703","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jacl.2010.01.006","volume":"4","year":"2010","journal-title":"JOURNAL OF CLINICAL LIPIDOLOGY"},{"issue":"8","key":"43_40240110","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1161\/STROKEAHA.110.608539","volume":"42","year":"2011","journal-title":"Stroke","ISSN":"https:\/\/id.crossref.org\/issn\/0039-2499","issn-type":"print"},{"issue":"7","key":"44_18957146","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1007\/s00198-004-1757-4","volume":"16","author":"Pepe","year":"2005","journal-title":"Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA","ISSN":"https:\/\/id.crossref.org\/issn\/0937-941X","issn-type":"print"},{"issue":"20","key":"45_18465157","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1016\/j.ehj.2004.07.010","volume":"25","author":"Andersson","year":"2004","journal-title":"European Heart Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0195-668X","issn-type":"print"},{"issue":"5","key":"46_29833968","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.surg.2007.06.015","volume":"142","author":"Costa-Hong","year":"2007","journal-title":"Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0039-6060","issn-type":"print"},{"issue":"21","key":"47_34875046","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.1161\/CIRCULATIONAHA.108.808733","volume":"119","year":"2009","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"issue":"9","key":"48_19321674","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1097\/01.hjh.0000179764.40701.36","volume":"23","author":"Jorde","year":"2005","journal-title":"Journal of hypertension","ISSN":"https:\/\/id.crossref.org\/issn\/0263-6352","issn-type":"print"},{"key":"49_34654305","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/01.hjr.0000114706.27531.01","volume":"11","year":"2004","journal-title":"EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION AND REHABILITATION"},{"issue":"10","key":"50_37545700","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1093\/eurjhf\/hfq112","volume":"12","year":"2010","journal-title":"European Journal of Heart Failure","ISSN":"https:\/\/id.crossref.org\/issn\/1388-9842","issn-type":"print"},{"issue":"6","key":"51_34958089","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1592\/phco.29.6.691","volume":"29","author":"Nemerovski","year":"2009","ISSN":"https:\/\/id.crossref.org\/issn\/1875-9114","issn-type":"print"},{"key":"52_43637705","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/mnfr.200900474","volume":"54","year":"2010","journal-title":"MOLECULAR NUTRITION FOOD RESEARCH"},{"issue":"3","key":"53_42532935","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1210\/er.2012-1000","volume":"33","year":"2012","journal-title":"Endocrine Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0163-769X","issn-type":"print"},{"issue":"8","key":"54_42532889","doi-asserted-by":"publisher","first-page":"2644","DOI":"10.1210\/jc.2012-1176","volume":"97","year":"2012","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"15","key":"55_31633278","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1001\/archinte.168.15.1629","volume":"168","author":"Melamed","year":"2008","journal-title":"Archives of Internal Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9926","issn-type":"print"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/167\/4\/553.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/167\/4\/553.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T08:24:45Z","timestamp":1714292685000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/167\/4\/553\/6659416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":52,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/eje-12-0283","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}