{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T16:10:25Z","timestamp":1782490225873,"version":"3.54.5"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether a population-level decline in serum testosterone exists in Finnish men. In comparison with other European populations, Finnish men have compared well in the studies of reproductive health (i.e. semen quality, incidence of cryptorchidism and testicular cancer); thus, we expected no significant cohort-dependent decrease in serum testosterone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed serum levels of testosterone, gonadotrophin and sex hormone binding globulin (SHBG) in 3271 men representing different ages (25\u201374 years) and birth cohorts within three large Finnish population surveys conducted in 1972, 1977 and 2002.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum testosterone levels decreased (from 25.3\u200anmol\/l in 25- to 29-year-old men gradually to 16.9\u200anmol\/l in 70- to 74-year-old men), whereas SHBG and gonadotrophin levels increased with increasing age. In addition, a significant secular trend in testosterone (total and free), SHBG and gonadotrophin levels was observed with lower levels in more recently born age-matched men. Serum testosterone level decreased in men aged 60\u201369 years from 21.9\u200anmol\/l (men born 1913\u20131922) to 13.8\u200anmol\/l (men born 1942\u20131951). These decreases remained significant following adjustment for BMI. An age-independent birth cohort effect existed on reproductive hormones measured in the Finnish men. In concert with the lower free testosterone levels, we observed lower gonadotrophin levels, suggesting that while there may be detrimental changes at the gonad level, the hypothalamus\u2013pituitary\u2013axis is not responding appropriately to this change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The more recently born Finnish men have lower testosterone levels than their earlier born peers. This study offers no explanation for this substantial recent adverse development.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-12-0288","type":"journal-article","created":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T05:04:10Z","timestamp":1353042250000},"page":"227-233","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":49,"title":["A cohort effect on serum testosterone levels in Finnish men"],"prefix":"10.1093","volume":"168","author":[{"given":"A","family":"Perheentupa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"M\u00e4kinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Laatikainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Vierula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N E","family":"Skakkebaek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A-M","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Toppari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"8","key":"1_5967599","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1093\/oxfordjournals.aje.a009519","volume":"147","author":"Ferrini","year":"1998","journal-title":"American Journal of Epidemiology","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9262","issn-type":"print"},{"issue":"2","key":"2_11039521","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1210\/jc.86.2.724","volume":"86","author":"Harman","year":"2001","journal-title":"Journal of Clinical Endocrinology &amp; 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