{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:35:51Z","timestamp":1793900151235,"version":"4.8.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate health-related quality of life (HRQoL) in Cushing's syndrome (CS) with the disease-generated CushingQoL questionnaire and to confirm its psychometric properties of test\u2013retest reliability and sensitivity to change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Clinical practice conditions in a tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The CushingQoL and EuroQoL questionnaires were administered at baseline and during follow-up and correlated with clinical parameters in 59 patients with CS. To check test\u2013retest reliability, stable patients (either biochemically cured or with active hypercortisolism) were evaluated twice. To investigate sensitivity to change, new patients were evaluated at diagnosis and twice more following improvement after successful surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, patients with active disease scored lower (indicating worse HRQoL) than those cured on the CushingQoL (46\u00b114 vs 58\u00b120,<jats:italic>P<\/jats:italic>&lt;0.05) but not on the EuroQoL-visual analog scale (VAS; 64\u00b120 vs 70\u00b116,<jats:italic>P<\/jats:italic>NS). Test\u2013retest reliability of CushingQoL was confirmed in stable patients, both in the \u2018cured group\u2019 (intraclass correlation coefficient (ICC)=0.78,<jats:italic>n<\/jats:italic>=34) and in the \u2018active group\u2019 (ICC=0.66,<jats:italic>n<\/jats:italic>=14). Sensitivity to change was confirmed in the \u2018improvement group\u2019 (<jats:italic>n<\/jats:italic>=11), as the CushingQoL score increased 4\u00b11.5 and 9\u00b13 months after surgery (<jats:italic>P<\/jats:italic>&lt;0.01 and &lt;0.001 respectively); the EuroQoL-VAS only improved after 9\u00b13 months (<jats:italic>P<\/jats:italic>&lt;0.01). Effect sizes were 1.02 and 1.86 for CushingQoL at 4\u00b11.5 and 9\u00b13 months respectively. Finally, scores of both questionnaires were correlated (<jats:italic>r<\/jats:italic>=0.504;<jats:italic>P<\/jats:italic>&lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The CushingQoL questionnaire shows good test\u2013retest reliability and sensitivity to change in clinical practice conditions.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-12-0325","type":"journal-article","created":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T03:45:07Z","timestamp":1339127107000},"page":"337-342","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":45,"title":["Psychometric performance of the CushingQoL questionnaire in conditions of real clinical 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