{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:45:49Z","timestamp":1774464349851,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The ACTH\u2013cortisol axis in women is activated and associated with decreased ACTH potency, estimated by relating ACTH and cortisol pulse masses. Recently, a new accurate method for constructing the endogenous dose\u2013response relationship was introduced, which is based on the relation between ACTH concentrations and associated cortisol secretion rates within cortisol bursts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>The endogenous dose\u2013response relation between ACTH and cortisol in obesity is changed, leading to diminished responsiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Twenty-five obese premenopausal women and 16 normal weight premenopausal women were studied by 10-min blood sampling for 24 h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcomes<\/jats:title><jats:p>ACTH and cortisol secretion rates, analytical dose\u2013response estimates of endogenous ACTH efficacy (maximal cortisol secretion), dynamic ACTH potency, and adrenal sensitivity (slope term) from 24-h ACTH\u2013cortisol profiles were quantified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The initial potency (negative logarithm) was \u22127.83\u00b10.75 (mean\u00b1<jats:sc>s.e.m<\/jats:sc>.) in obese women and \u221210.14\u00b11.08 in lean women (<jats:italic>P<\/jats:italic>=0.10), and the corresponding values for the recovery phase were \u221226.62\u00b12.21 and \u221236.67\u00b11.66 (<jats:italic>P<\/jats:italic>=0.004). The sensitivity (curve slope) amounted to 0.468\u00b10.05 in obese women and 0.784\u00b10.09 in normal weight women (<jats:italic>P<\/jats:italic>=0.004). The efficacy (maximal value) was 17.6\u00b14.9\u200anmol\/l per min in obese women and 26.3\u00b13.8\u200anmol\/l per min in normal weight women (<jats:italic>P<\/jats:italic>=0.009). Basal secretion rate, inflection point, and EC<jats:sub>50<\/jats:sub>values were not different. Bromocriptine or acipimox did not change the dose\u2013response curve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The ACTH\u2013cortisol relation in obesity in women is characterized by decreased sensitivity and efficacy, thus explaining non-elevated serum cortisol concentrations despite increased plasma ACTH levels.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-12-0592","type":"journal-article","created":{"date-parts":[[2012,8,22]],"date-time":"2012-08-22T04:02:46Z","timestamp":1345608166000},"page":"633-642","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":20,"title":["Diminished adrenal sensitivity and ACTH efficacy in obese premenopausal women"],"prefix":"10.1093","volume":"167","author":[{"given":"Ferdinand","family":"Roelfsema","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanno","family":"Pijl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M","family":"Keenan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes D","family":"Veldhuis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"issue":"4","key":"1_17986253","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/S0889-8529(03)00078-1","volume":"32","author":"Kokkoris","year":"2003","journal-title":"Endocrinology and metabolism clinics of North America","ISSN":"https:\/\/id.crossref.org\/issn\/0889-8529","issn-type":"print"},{"issue":"9 Suppl 3","key":"2_16009313","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/0026-0495(95)90315-1","volume":"44","author":"Bj\u00a0\u00a0rntorp","year":"1995","journal-title":"Metabolism: clinical and experimental","ISSN":"https:\/\/id.crossref.org\/issn\/0026-0495","issn-type":"print"},{"issue":"6","key":"3_6272022","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1210\/er.19.6.717","volume":"19","author":"Giustina","year":"1998","journal-title":"Endocrine Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0163-769X","issn-type":"print"},{"issue":"7","key":"4_28375902","doi-asserted-by":"publisher","first-page":"2468","DOI":"10.1210\/jc.2006-2274","volume":"92","year":"2007","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"11","key":"5_19129865","doi-asserted-by":"publisher","first-page":"6185","DOI":"10.1210\/jc.2005-0003","volume":"90","year":"2005","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"2","key":"6_21169474","doi-asserted-by":"publisher","first-page":"E218","DOI":"10.1152\/ajpendo.00156.2005","volume":"290","year":"2006","journal-title":"American Journal of Physiology - Endocrinology And Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0193-1849","issn-type":"print"},{"issue":"8","key":"7_9917505","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/0026-0495(92)90171-6","volume":"41","author":"M\u00a0\u00a0rin","year":"1992","journal-title":"Metabolism: clinical and experimental","ISSN":"https:\/\/id.crossref.org\/issn\/0026-0495","issn-type":"print"},{"issue":"5","key":"8_6004197","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1210\/jc.83.5.1806","volume":"83","author":"Andrew","year":"1998","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"1","key":"9_17990974","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1210\/jc.2003-030440","volume":"89","author":"Purnell","year":"2004","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"8","key":"10_34884059","doi-asserted-by":"publisher","first-page":"2991","DOI":"10.1210\/jc.2009-0350","volume":"94","year":"2009","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"2","key":"11_35063968","doi-asserted-by":"publisher","first-page":"R515","DOI":"10.1152\/ajpregu.00200.2009","volume":"297","year":"2009","journal-title":"American Journal of Physiology - Regulatory, Integrative and Comparative Physiology","ISSN":"https:\/\/id.crossref.org\/issn\/0363-6119","issn-type":"print"},{"issue":"5","key":"12_19633793","doi-asserted-by":"publisher","first-page":"E848","DOI":"10.1152\/ajpendo.00254.2004","volume":"287","year":"2004","journal-title":"American Journal of Physiology - Endocrinology And Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0193-1849","issn-type":"print"},{"issue":"4","key":"13_19656973","doi-asserted-by":"crossref","first-page":"R693","DOI":"10.1152\/ajpregu.00595.2003","volume":"286","year":"2004","journal-title":"American Journal of Physiology - Regulatory, Integrative and Comparative Physiology","ISSN":"https:\/\/id.crossref.org\/issn\/0363-6119","issn-type":"print"},{"issue":"8","key":"14_22126646","doi-asserted-by":"publisher","first-page":"3236","DOI":"10.1210\/jc.2005-2529","volume":"91","year":"2006","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"5","key":"15_22328680","doi-asserted-by":"publisher","first-page":"E1038","DOI":"10.1152\/ajpendo.00567.2005","volume":"291","year":"2006","journal-title":"American Journal of Physiology - Endocrinology And Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0193-1849","issn-type":"print"},{"issue":"17","key":"16_19685880","doi-asserted-by":"publisher","first-page":"6740","DOI":"10.1073\/pnas.0300619101","volume":"101","year":"2004","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"4","key":"17_19633771","doi-asserted-by":"publisher","first-page":"E652","DOI":"10.1152\/ajpendo.00167.2004","volume":"287","year":"2004","journal-title":"American Journal of Physiology - Endocrinology And Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0193-1849","issn-type":"print"},{"issue":"5","key":"18_40011615","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/j.1365-2265.2011.04125.x","volume":"75","author":"Iranmanesh","year":"2011","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"1","key":"19_37139850","doi-asserted-by":"publisher","first-page":"R11","DOI":"10.1152\/ajpregu.00201.2010","volume":"299","year":"2010","journal-title":"American Journal of Physiology - Regulatory, Integrative and Comparative Physiology","ISSN":"https:\/\/id.crossref.org\/issn\/0363-6119","issn-type":"print"},{"issue":"2","key":"20_35056943","doi-asserted-by":"publisher","first-page":"E538","DOI":"10.1152\/ajpendo.00071.2009","volume":"297","year":"2009","journal-title":"American Journal of Physiology - Endocrinology And Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0193-1849","issn-type":"print"},{"issue":"2","key":"21_38593148","doi-asserted-by":"publisher","first-page":"R349","DOI":"10.1152\/ajpregu.00477.2010","volume":"300","year":"2011","journal-title":"American Journal of Physiology - Regulatory, Integrative and Comparative Physiology","ISSN":"https:\/\/id.crossref.org\/issn\/0363-6119","issn-type":"print"},{"issue":"3","key":"22_8656486","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/0026-0495(82)90054-3","volume":"31","author":"Strain","year":"1982","journal-title":"Metabolism: clinical and experimental","ISSN":"https:\/\/id.crossref.org\/issn\/0026-0495","issn-type":"print"},{"issue":"7","key":"23_16825614","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.2337\/diab.46.7.1235","volume":"46","author":"Bornstein","year":"1997","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"issue":"10","key":"24_6162071","doi-asserted-by":"publisher","first-page":"4264","DOI":"10.1210\/en.139.10.4264","volume":"139","author":"Pralong","year":"1998","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"issue":"7","key":"25_34501654","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1210\/en.2008-1706","volume":"150","year":"2009","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"issue":"5","key":"26_10797412","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1046\/j.1460-9568.1999.00575.x","volume":"11","author":"Buijs","year":"1999","journal-title":"The European journal of neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0953-816X","issn-type":"print"},{"issue":"1","key":"27_11067403","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1210\/jc.86.1.151","volume":"86","author":"Leproult","year":"2001","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"20","key":"28_17325697","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1161\/01.CIR.0000041244.79165.25","volume":"106","year":"2002","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"issue":"2","key":"29_14408842","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1210\/jc.77.2.341","volume":"77","author":"Pasquali","year":"1993","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"30_16205786","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S0026-0495(96)90290-5","volume":"45","author":"Pasquali","year":"1996","journal-title":"Metabolism: clinical and experimental","ISSN":"https:\/\/id.crossref.org\/issn\/0026-0495","issn-type":"print"},{"issue":"1","key":"31_5021518","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1365-2265.1988.tb01197.x","volume":"28","author":"Kopelman","year":"1988","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"11","key":"32_29342709","doi-asserted-by":"publisher","first-page":"4199","DOI":"10.1210\/jc.2007-0774","volume":"92","year":"2007","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"9","key":"33_11313059","doi-asserted-by":"publisher","first-page":"4109","DOI":"10.1210\/jc.86.9.4109","volume":"86","author":"Jessop","year":"2001","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"34_14494700","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1365-2265.1993.tb02375.x","volume":"39","author":"Weaver","year":"1993","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"key":"35_28286695","first-page":"291","volume":"183","year":"1993","journal-title":"Journal of Anatomy","ISSN":"https:\/\/id.crossref.org\/issn\/1469-7580","issn-type":"print"},{"issue":"5","key":"36_39930895","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1210\/er.2003-0031","volume":"25","year":"2004","journal-title":"Endocrine Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0163-769X","issn-type":"print"},{"issue":"10","key":"37_31509989","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.2337\/db08-0495","volume":"57","year":"2008","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"issue":"6","key":"38_42372206","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.2337\/db11-1345","volume":"61","year":"2012","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"issue":"5","key":"39_6080164","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1046\/j.1365-2265.1998.00458.x","volume":"48","author":"Pasquali","year":"1998","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"4","key":"40_5587676","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1210\/endo-126-4-1880","volume":"126","author":"BESTETTI","year":"1990","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"issue":"1","key":"41_5838731","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1523\/JNEUROSCI.18-01-00559.1998","volume":"18","author":"Hakansson","year":"1998","journal-title":"Journal of Neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0270-6474","issn-type":"print"},{"issue":"2","key":"42_6325071","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/353","volume":"1","author":"Gardner","year":"1998","journal-title":"Nature neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/1097-6256","issn-type":"print"},{"issue":"11","key":"43_10529190","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1093\/jn\/130.11.2813","volume":"130","author":"Jang","year":"2000","journal-title":"The Journal of Nutrition","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3166","issn-type":"print"},{"issue":"6","key":"44_6017684","doi-asserted-by":"crossref","first-page":"890","DOI":"10.2337\/diabetes.47.6.890","volume":"47","author":"Uehara","year":"1998","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"issue":"1","key":"45_11474334","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1210\/jc.87.1.166","volume":"87","author":"Pasquali","year":"2002","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"46_6040752","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1210\/er.19.3.269","volume":"19","author":"de Kloet","year":"1998","journal-title":"Endocrine Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0163-769X","issn-type":"print"},{"issue":"12","key":"47_19675765","doi-asserted-by":"publisher","first-page":"5587","DOI":"10.1210\/en.2005-0501","volume":"146","year":"2005","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"issue":"9","key":"48_40285312","doi-asserted-by":"publisher","first-page":"2874","DOI":"10.1210\/jc.2011-0084","volume":"96","year":"2011","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"12","key":"49_40722302","doi-asserted-by":"publisher","first-page":"3768","DOI":"10.1210\/jc.2011-1878","volume":"96","year":"2011","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"50_19280654","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.jtbi.2005.03.008","volume":"236","author":"Keenan","year":"2005","journal-title":"Journal of Theoretical Biology","ISSN":"https:\/\/id.crossref.org\/issn\/1095-8541","issn-type":"print"},{"key":"51_35272949","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1090\/S0033-569X-08-01024-4","volume":"66","year":"2008","journal-title":"QUARTERLY OF APPLIED MATHEMATICS"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/167\/5\/633.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/167\/5\/633.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:28:33Z","timestamp":1676392113000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/167\/5\/633\/6659444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":51,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.1530\/eje-12-0592","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}