{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T10:51:27Z","timestamp":1753440687337},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>Ventricular hypertrophy (VH) has been observed in children with congenital hyperinsulinism (CHI), a condition of hypoglycaemia characterised by dysregulated insulin secretion, but the prevalence is not known.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Patients and methods<\/jats:title>\n<jats:p>Cardiac assessment was performed in children (<jats:italic>n<\/jats:italic>=49) with CHI at diagnosis and follow-up. Two dimensional and Doppler echocardiography studies were used to assess cardiac structures, while M-mode study was used to measure left ventricular (LV) dimensions, subsequently converted to <jats:italic>Z<\/jats:italic> scores. Where possible, LV hypertrophy was confirmed by LV mass index (g\/m<jats:sup>2.7<\/jats:sup>) &gt;95th centile.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Cardiac structural lesions were found in 14 (28%) children. At initial echocardiography, VH was present in 31 (65%) children with median (range) LV posterior wall dimension in diastole <jats:italic>Z<\/jats:italic> scores of +1.6 (\u22122.4 to +5.8) and interventricular septal wall dimension in end diastole <jats:italic>Z<\/jats:italic> scores of +1.9 (\u22121.7 to +17.2). At follow-up echocardiography, performed after an interval of 178 (45\u2013390) days, VH persisted in 16 (33%) children. In regression analysis, the presence of VH (odds ratio (95% confidence intervals) 1.1 (1.0\u20131.2), <jats:italic>P<\/jats:italic>=0.04) at initial echocardiography was correlated with maximum glucose requirement at diagnosis, indicating that severity of CHI at presentation may play a role in the pathogenesis of VH.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>A significant proportion of children with CHI have cardiac structural lesions. A majority also have VH, which may be associated with the severity of CHI at diagnosis. VH may persist in some children, which requires careful long-term cardiac review.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-12-0632","type":"journal-article","created":{"date-parts":[[2012,8,16]],"date-time":"2012-08-16T00:58:57Z","timestamp":1345078737000},"page":"619-624","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":9,"title":["The association of cardiac ventricular hypertrophy with congenital hyperinsulinism"],"prefix":"10.1093","volume":"167","author":[{"given":"Indraneel","family":"Banerjee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bindu","family":"Avatapalle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali","family":"Petkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mars","family":"Skae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja","family":"Padidela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Ehtisham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leena","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey","family":"Rigby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Flanagan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sian","family":"Ellard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Ciotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilima","family":"Malaiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter E","family":"Clayton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"1_43877081","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/ncpendmet1046","volume":"5","year":"2009","journal-title":"NATURE CLINICAL PRACTICE ENDOCRINOLOGY METABOLISM"},{"issue":"5","key":"2_34177011","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1136\/jmg.2008.064337","volume":"46","year":"2009","journal-title":"Journal of Medical Genetics","ISSN":"http:\/\/id.crossref.org\/issn\/0022-2593","issn-type":"print"},{"issue":"5","key":"3_39376713","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1530\/EJE-10-1136","volume":"164","year":"2011","journal-title":"European Journal of Endocrinology","ISSN":"http:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"2","key":"4_6480324","doi-asserted-by":"publisher","first-page":"F98","DOI":"10.1136\/fn.82.2.F98","volume":"82","author":"Aynsley-Green","year":"2000","journal-title":"Archives of Disease in Childhood - Fetal and Neonatal Edition","ISSN":"http:\/\/id.crossref.org\/issn\/1359-2998","issn-type":"print"},{"issue":"2 Pt 1","key":"5_9714304","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/S0022-3476(05)80442-1","volume":"120","author":"Harris","year":"1992","journal-title":"The Journal of pediatrics","ISSN":"http:\/\/id.crossref.org\/issn\/0022-3476","issn-type":"print"},{"issue":"6","key":"6_6467895","first-page":"359","volume":"54","author":"Massin","year":"1999","journal-title":"Acta cardiologica","ISSN":"http:\/\/id.crossref.org\/issn\/0001-5385","issn-type":"print"},{"issue":"2","key":"7_38712840","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ijcard.2010.10.058","volume":"146","author":"Mormile","year":"2011","journal-title":"International journal of cardiology","ISSN":"http:\/\/id.crossref.org\/issn\/0167-5273","issn-type":"print"},{"issue":"1","key":"8_30374233","doi-asserted-by":"publisher","first-page":"10","DOI":"10.2350\/07-05-0277.1","volume":"11","author":"Russell","year":"2008","journal-title":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","ISSN":"http:\/\/id.crossref.org\/issn\/1093-5266","issn-type":"print"},{"key":"9_43877082","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/ejechocard\/jer176","volume":"13","year":"2012","journal-title":"EUROPEAN HEART JOURNAL CARDIOVASCULAR IMAGING"},{"issue":"3","key":"10_37264387","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3109\/15513811003777334","volume":"29","author":"Bulbul","year":"2010","journal-title":"Fetal and pediatric pathology","ISSN":"http:\/\/id.crossref.org\/issn\/1551-3815","issn-type":"print"},{"key":"11_43877083","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1750-1172-6-63","volume":"6","year":"2011","journal-title":"ORPHANET JOURNAL OF RARE DISEASES"},{"key":"12_43877084","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/ncpendmet0368","volume":"3","year":"2007","journal-title":"NATURE CLINICAL PRACTICE ENDOCRINOLOGY METABOLISM"},{"issue":"6","key":"13_33873261","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1136\/adc.2008.148171","volume":"94","year":"2009","journal-title":"Archives of Disease in Childhood","ISSN":"http:\/\/id.crossref.org\/issn\/0003-9888","issn-type":"print"},{"issue":"4","key":"14_41783609","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s10545-011-9441-2","volume":"35","author":"Senniappan","year":"2012","journal-title":"Journal of inherited metabolic disease","ISSN":"http:\/\/id.crossref.org\/issn\/0141-8955","issn-type":"print"},{"issue":"5","key":"15_35445724","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1017\/S1047951109990862","volume":"19","author":"Geelhoed","year":"2009","journal-title":"Cardiology in the young","ISSN":"http:\/\/id.crossref.org\/issn\/1047-9511","issn-type":"print"},{"issue":"6","key":"16_10319879","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1136\/heart.83.6.667","volume":"83","author":"Kampmann","year":"2000","journal-title":"Heart","ISSN":"http:\/\/id.crossref.org\/issn\/0007-0769","issn-type":"print"},{"issue":"21","key":"17_31120686","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1161\/CIRCULATIONAHA.107.741157","volume":"117","year":"2008","journal-title":"Circulation","ISSN":"http:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"issue":"6","key":"18_34804059","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.echo.2009.03.003","volume":"22","author":"Khoury","year":"2009","journal-title":"Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography","ISSN":"http:\/\/id.crossref.org\/issn\/0894-7317","issn-type":"print"},{"issue":"5","key":"19_18504299","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.yjmcc.2004.07.002","volume":"37","author":"Xia","year":"2004","journal-title":"Journal of molecular and cellular cardiology","ISSN":"http:\/\/id.crossref.org\/issn\/0022-2828","issn-type":"print"},{"issue":"3","key":"20_38932977","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.yjmcc.2010.12.011","volume":"50","author":"Zhang","year":"2011","journal-title":"Journal of molecular and cellular cardiology","ISSN":"http:\/\/id.crossref.org\/issn\/0022-2828","issn-type":"print"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/167\/5\/619.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/167\/5\/619.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:28:36Z","timestamp":1676392116000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/167\/5\/619\/6659415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":20,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.1530\/eje-12-0632","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}