{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T23:30:18Z","timestamp":1769902218161,"version":"3.49.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Thyroglobulin antibody (TgAb) is an important autoantibody in thyroid diseases, which is a glycoprotein, predominantly of IgG class. Glycosylation of the IgG-Fc contributes to many effector functions exhibited by antibodies. The aim of our study was to investigate the glycosylation of sera TgAb in patients with different thyroid diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and methods<\/jats:title><jats:p>Sera from 146 patients were collected and divided into four groups: Hashimoto's thyroiditis (HT, <jats:italic>n<\/jats:italic>=90), Graves' disease (GD, <jats:italic>n<\/jats:italic>=20), papillary thyroid carcinoma (PTC, <jats:italic>n<\/jats:italic>=17), and PTC with histological lymphocytic thyroiditis (PTC-T, <jats:italic>n<\/jats:italic>=19). HT patients were further divided into euthyroidism and subclinical and overt hypothyroidism groups. Lectin-ELISAs were performed to detect the relative amount of core fucose, terminal galactose, and sialic acid on each TgAb respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among HT, GD, and PTC groups, HT patients had significantly lower core fucose content on TgAb than the other two groups; an increasing trend of sialylation was found in PTC sera (<jats:italic>P<\/jats:italic>=0.076) compared with HT groups. PTC-T patients had significantly higher sialylated TgAb than HT and GD patients, and no significant difference was found between PTC and PTC-T. There was no significant difference in the three carbohydrate residue contents on sera TgAb among HT subgroups. In all the patients, negative correlation was found between sialic acid content and TgAb IgG levels (<jats:italic>r<\/jats:italic>=\u22120.736, <jats:italic>P<\/jats:italic>&lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study showed that glycosylation of sera TgAb varied in different thyroid diseases and it might be involved in pathogenesis of thyroid disorders.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-12-0964","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T01:53:04Z","timestamp":1359510784000},"page":"585-592","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":20,"title":["Glycosylation of sera thyroglobulin antibody in patients with thyroid diseases"],"prefix":"10.1093","volume":"168","author":[{"given":"Lanlan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guizhi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanming","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingyin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"issue":"2","key":"1_16908699","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1210\/jc.87.2.489","volume":"87","author":"Hollowell","year":"2002","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"4","key":"2_5957035","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1210\/jc.83.4.1121","volume":"83","author":"Spencer","year":"1998","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"2","key":"3_12498515","first-page":"153","volume":"14","author":"Calder","year":"1973","journal-title":"Clinical and experimental immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9104","issn-type":"print"},{"issue":"12","key":"4_40722300","doi-asserted-by":"publisher","first-page":"3615","DOI":"10.1210\/jc.2011-1740","volume":"96","year":"2011","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"7","key":"5_7589355","first-page":"621","volume":"3","author":"Torrigiani","year":"1968","journal-title":"Clinical and experimental immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9104","issn-type":"print"},{"key":"6_40579562","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/978-1-4419-5632-3_10","volume":"780","author":"Lux","year":"2011","journal-title":"Advances in experimental medicine and biology","ISSN":"https:\/\/id.crossref.org\/issn\/0065-2598","issn-type":"print"},{"issue":"4","key":"7_31450746","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.coi.2008.06.007","volume":"20","author":"Raju","year":"2008","journal-title":"Current opinion in immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0952-7915","issn-type":"print"},{"issue":"30","key":"8_19555752","doi-asserted-by":"publisher","first-page":"26733","DOI":"10.1074\/jbc.M202069200","volume":"277","year":"2002","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"11","key":"9_22833421","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1517\/14712598.6.11.1161","volume":"6","author":"Satoh","year":"2006","journal-title":"Expert opinion on biological therapy","ISSN":"https:\/\/id.crossref.org\/issn\/1471-2598","issn-type":"print"},{"issue":"7","key":"10_23056588","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1016\/j.molimm.2006.09.005","volume":"44","author":"Scallon","year":"2007","journal-title":"Molecular immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0161-5890","issn-type":"print"},{"issue":"5787","key":"11_22443925","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1126\/science.1129594","volume":"313","author":"Kaneko","year":"2006","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"3","key":"12_9749751","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1172\/JCI115643","volume":"89","author":"Axford","year":"1992","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"issue":"3","key":"13_17777120","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1046\/j.1365-2249.2003.02220.x","volume":"133","author":"Cremata","year":"2003","journal-title":"Clinical and experimental immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9104","issn-type":"print"},{"issue":"5B","key":"14_18492881","first-page":"3135","volume":"24","author":"KANOH","year":"2004","journal-title":"Anticancer Research","ISSN":"https:\/\/id.crossref.org\/issn\/0250-7005","issn-type":"print"},{"issue":"1","key":"15_11091603","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1006\/gyno.2000.6102","volume":"81","author":"Ger\u00a0\u00a0el-Taylor","year":"2001","journal-title":"Gynecologic oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0090-8258","issn-type":"print"},{"issue":"1","key":"16_41711667","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s10719-011-9364-z","volume":"29","author":"Kodar","year":"2012","journal-title":"Glycoconjugate journal","ISSN":"https:\/\/id.crossref.org\/issn\/0282-0080","issn-type":"print"},{"issue":"2","key":"17_16444946","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/0009-8981(96)06326-7","volume":"252","author":"Keusch","year":"1996","journal-title":"Clinica Chimica Acta","ISSN":"https:\/\/id.crossref.org\/issn\/1873-3492","issn-type":"print"},{"issue":"1-2","key":"18_32417745","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.clinbiochem.2008.09.114","volume":"42","author":"Radziejewska","year":"2009","journal-title":"Clinical biochemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9120","issn-type":"print"},{"issue":"7-8","key":"19_22693178","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s10719-006-5409-0","volume":"23","author":"Pasek","year":"2006","journal-title":"Glycoconjugate journal","ISSN":"https:\/\/id.crossref.org\/issn\/0282-0080","issn-type":"print"},{"issue":"1","key":"20_38861017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10719-010-9316-z","volume":"28","author":"Mondal","year":"2011","journal-title":"Glycoconjugate journal","ISSN":"https:\/\/id.crossref.org\/issn\/0282-0080","issn-type":"print"},{"issue":"13","key":"21_16045388","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/0161-5890(95)00078-S","volume":"32","author":"Endo","year":"1995","journal-title":"Molecular immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0161-5890","issn-type":"print"},{"key":"22_45420294","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1016\/j.jprot.2012.02.001","volume":"75","year":"2012","journal-title":"JOURNAL OF PROTEOMICS"},{"key":"23_45420295","doi-asserted-by":"crossref","first-page":"M110.004655","DOI":"10.1074\/mcp.M110.004655","volume":"10","year":"2011","journal-title":"MOLECULAR AND CELLULAR PROTEOMICS"},{"issue":"1","key":"24_8670718","first-page":"196","volume":"48","author":"Weetman","year":"1982","journal-title":"Clinical and experimental immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9104","issn-type":"print"},{"issue":"8","key":"25_19731651","doi-asserted-by":"publisher","first-page":"5032","DOI":"10.1074\/jbc.M510171200","volume":"281","year":"2006","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"11","key":"26_37287696","doi-asserted-by":"publisher","first-page":"4481","DOI":"10.1158\/0008-5472.CAN-09-3704","volume":"70","year":"2010","journal-title":"Cancer Research","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"issue":"2-3","key":"27_32621143","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s10616-007-9103-2","volume":"55","author":"Mori","year":"2007","journal-title":"Cytotechnology","ISSN":"https:\/\/id.crossref.org\/issn\/0920-9069","issn-type":"print"},{"issue":"6","key":"28_19730130","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1021\/bp050228w","volume":"21","author":"Hodoniczky","year":"2005","journal-title":"Biotechnology Progress (Print)","ISSN":"https:\/\/id.crossref.org\/issn\/1520-6033","issn-type":"print"},{"issue":"4","key":"29_18493852","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1080\/08916930410001705394","volume":"37","author":"Weetman","year":"2004","journal-title":"Autoimmunity","ISSN":"https:\/\/id.crossref.org\/issn\/0891-6934","issn-type":"print"},{"issue":"2","key":"30_29895770","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1210\/jc.2007-1199","volume":"93","year":"2008","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"2","key":"31_32340788","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1021\/pr800651j","volume":"8","author":"Wuhrer","year":"2009","journal-title":"Journal of proteome research","ISSN":"https:\/\/id.crossref.org\/issn\/1535-3893","issn-type":"print"},{"issue":"1","key":"32_15973357","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/j.1365-2265.1995.tb01894.x","volume":"43","author":"Vanderpump","year":"1995","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"2","key":"33_5353875","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0896-8411(89)90148-0","volume":"2","author":"Parekh","year":"1989","journal-title":"Journal of autoimmunity","ISSN":"https:\/\/id.crossref.org\/issn\/0896-8411","issn-type":"print"},{"issue":"9","key":"34_37500025","doi-asserted-by":"publisher","first-page":"4583","DOI":"10.1210\/en.2010-0321","volume":"151","year":"2010","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"issue":"1","key":"35_38333762","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1530\/EJE-10-0785","volume":"164","year":"2011","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"key":"37_28550161","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1146\/annurev.immunol.25.022106.141702","volume":"25","author":"Arnold","year":"2007","journal-title":"Annual review of immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0732-0582","issn-type":"print"},{"issue":"21","key":"38_9614049","first-page":"5888","volume":"51","author":"Kinoshita","year":"1991","journal-title":"Cancer Research","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"issue":"4","key":"39_9978981","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3109\/08916939209148468","volume":"12","author":"Kiso","year":"1992","journal-title":"Autoimmunity","ISSN":"https:\/\/id.crossref.org\/issn\/0891-6934","issn-type":"print"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/168\/4\/585.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/168\/4\/585.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:28:58Z","timestamp":1676392138000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/168\/4\/585\/6659647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":38,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/eje-12-0964","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}