{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:08:43Z","timestamp":1792152523247,"version":"4.4.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Sclerostin inhibits osteoblast differentiation and bone formation. If aberrant sclerostin action is involved in less efficient bone acquisition in men with idiopathic low bone mass, this might be reflected in higher serum sclerostin levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 116 men with idiopathic osteoporosis (\u226465 years old), 40 of their sons and healthy controls, areal bone parameters were measured using dual-energy X-ray absorptiometry, and volumetric and geometric bone parameters were measured using peripheral quantitative computed tomography. Serum analytes were measured using immunoassays and estradiol (E<jats:sub>2<\/jats:sub>) levels using liquid chromatography\u2013tandem mass spectrometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Men with idiopathic low bone mass had lower levels of sclerostin than the controls (0.54\u00b10.17 vs 0.66\u00b10.23\u200ang\/ml;<jats:italic>P<\/jats:italic>&lt;0.001). In both groups, sclerostin levels were strongly associated with age; when adjusting for age, no associations with anthropometrics were observed (<jats:italic>P<\/jats:italic>&gt;0.14). In multivariate analyses, sclerostin levels displayed a positive association with whole-body bone mineral content (BMC) and areal BMD (aBMD), as well as with trabecular and cortical volumetric bone mineral density (vBMD) at the tibia in the probands. No clear associations were observed in the control group, neither were sclerostin levels associated with BMC at the radius or lumbar spine (all<jats:italic>P<\/jats:italic>&gt;0.11). Testosterone, but not E<jats:sub>2<\/jats:sub>, was inversely related to sclerostin levels in the probands. No difference in sclerostin levels was found in their sons when compared with their controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lower rather than higher serum sclerostin levels in the probands with idiopathic low bone mass suggest that aberrant sclerostin secretion is not involved in the pathogenesis of low bone mass in these subjects.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-12-1074","type":"journal-article","created":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T07:22:02Z","timestamp":1360221722000},"page":"615-620","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":30,"title":["Serum sclerostin levels in men with idiopathic osteoporosis"],"prefix":"10.1093","volume":"168","author":[{"given":"B","family":"Lapauw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Vandewalle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Taes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Goemaere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Zmierczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Collette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"2_41485614","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.beem.2008.09.005","volume":"22","year":"2008","journal-title":"BEST PRACTICE RESEARCH CLINICAL ENDOCRINOLOGY METABOLISM"},{"issue":"2","key":"3_37312842","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00223-010-9372-1","volume":"87","author":"Moester","year":"2010","journal-title":"Calcified Tissue International","ISSN":"https:\/\/id.crossref.org\/issn\/1432-0827","issn-type":"print"},{"key":"4_45237240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2011.10.044","volume":"492","year":"2012","journal-title":"Gene","ISSN":"https:\/\/id.crossref.org\/issn\/0378-1119","issn-type":"print"},{"issue":"1","key":"5_40963656","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1210\/jc.2011-2152","volume":"97","year":"2012","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"4","key":"6_36628088","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1210\/jc.2009-2283","volume":"95","year":"2010","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"2","key":"7_37950489","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1002\/jbmr.217","volume":"26","author":"Modder","year":"2011","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"issue":"1","key":"9_37357263","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/jbmr.128","volume":"26","author":"Modder","year":"2011","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"issue":"10","key":"10_18463500","doi-asserted-by":"publisher","first-page":"4949","DOI":"10.1210\/jc.2003-032081","volume":"89","author":"Van Pottelbergh","year":"2004","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"11","key":"11_35627392","doi-asserted-by":"publisher","first-page":"4300","DOI":"10.1210\/jc.2009-0568","volume":"94","year":"2009","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"5","key":"12_8790522","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1093\/ajcn\/36.5.936","volume":"36","author":"Baecke","year":"1982","journal-title":"The American Journal of Clinical Nutrition","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9165","issn-type":"print"},{"key":"13_42919018","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jchromb.2012.02.034","volume":"893 894","year":"2012","journal-title":"Journal of chromatography. B, Analytical technologies in the biomedical and life sciences","ISSN":"https:\/\/id.crossref.org\/issn\/1570-0232","issn-type":"print"},{"issue":"10","key":"14_10996884","doi-asserted-by":"publisher","first-page":"3666","DOI":"10.1210\/jc.84.10.3666","volume":"84","author":"Vermeulen","year":"1999","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"4","key":"15_18464994","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1111\/j.1365-2265.2004.02117.x","volume":"61","author":"Szulc","year":"2004","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"12","key":"16_40481037","doi-asserted-by":"publisher","first-page":"2812","DOI":"10.1002\/jbmr.479","volume":"26","author":"Ardawi","year":"2011","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"issue":"9","key":"17_30094245","doi-asserted-by":"publisher","first-page":"5866","DOI":"10.1074\/jbc.M705092200","volume":"283","year":"2008","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"9","key":"18_42985264","doi-asserted-by":"publisher","first-page":"E1736","DOI":"10.1210\/jc.2012-1579","volume":"97","year":"2012","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"10","key":"19_34797011","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1359\/jbmr.090411","volume":"24","author":"Lin","year":"2009","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"key":"20_45420307","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/sj.ijo.0801955","volume":"26","year":"2002","journal-title":"INTERNATIONAL JOURNAL OF OBESITY AND RELATED METABOLIC DISORDERS"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/168\/4\/615.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/168\/4\/615.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:29:04Z","timestamp":1676392144000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/168\/4\/615\/6659690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":18,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/eje-12-1074","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}