{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:13:28Z","timestamp":1787022808540,"version":"build-2736575974"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The precise penetrance of pheochromocytoma (PHEO) in multiple endocrine neoplasia type 2 (MEN2) has not been reported in a large cohort. In this study, we aimed to clarify the codon-specific penetrance of PHEO in MEN2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>We established a study group designated the \u2018MEN Consortium of Japan\u2019 in 2008 and asked physicians and surgeons to provide clinical and genetic information on patients they had treated up to 2011.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data were collected on patients identified as carriers of the\n                      <jats:italic>RET<\/jats:italic>\n                      mutation or diagnosed with medullary thyroid carcinoma (MTC) and\/or PHEO with family history from 52 institutions all over Japan.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 493 registered MEN2 patients,\n                      <jats:italic>RET<\/jats:italic>\n                      mutation data were available for 390. Of these, 144developed PHEOs, while 246 did not. The penetrance of PHEO was 25% by age 30 years, 52% by age 50 years, and 88% by age 77 years in\n                      <jats:italic>RET<\/jats:italic>\n                      mutation carriers with a codon 634 mutation. All patients with a codon 918 mutation (MEN2B) developed PHEO by age 56 years. Less than 32%penetrance of PHEO was seen in patients with mutations at codons other than 634 and 918.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Most patients with a codon 634 mutation develop PHEOs as well as MTC during their lifetime.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/eje-12-1106","type":"journal-article","created":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T21:25:08Z","timestamp":1360963508000},"page":"683-687","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":70,"title":["High penetrance of pheochromocytoma in multiple endocrine neoplasia 2 caused by germ line RET codon 634 mutation in Japanese patients"],"prefix":"10.1093","volume":"168","author":[{"given":"Tsuneo","family":"Imai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Uchino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kosugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyone","family":"Kikumori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"_","family":"_","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"1_4696613","first-page":"105","volume":"8","author":"Carney","year":"1978","journal-title":"Pathobiology annual","ISSN":"https:\/\/id.crossref.org\/issn\/0362-3025","issn-type":"print"},{"issue":"5","key":"2_10293975","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1365-2265.1993.tb00350.x","volume":"38","author":"Casanova","year":"1993","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"4","key":"3_16081072","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-2796.1995.tb01211.x","volume":"238","author":"Modigliani","year":"1995","journal-title":"Journal of internal medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0954-6820","issn-type":"print"},{"issue":"12","key":"4_11433387","doi-asserted-by":"publisher","first-page":"5658","DOI":"10.1210\/jc.86.12.5658","volume":"86","author":"Brandi","year":"2001","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"6","key":"5_34937093","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1089\/thy.2008.0403","volume":"19","author":"Kloos Chair","year":"2009","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"4","key":"6_31915102","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1677\/ERC-08-0105","volume":"15","year":"2008","journal-title":"Endocrine-Related Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1351-0088","issn-type":"print"},{"issue":"6","key":"7_21167711","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1111\/j.1365-2265.2005.02400.x","volume":"63","author":"Tatsui","year":"2005","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"3","key":"8_36390249","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1210\/jc.2009-1355","volume":"95","year":"2010","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"7","key":"9_19273417","doi-asserted-by":"publisher","first-page":"3999","DOI":"10.1210\/jc.2005-0064","volume":"90","year":"2005","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"6","key":"10_10255605","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1097\/00000658-199306000-00001","volume":"217","author":"Lairmore","year":"1993","journal-title":"Annals of surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0003-4932","issn-type":"print"},{"issue":"11","key":"11_31937281","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1007\/s00268-008-9734-2","volume":"32","author":"Rodriguez","year":"2008","journal-title":"World journal of surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0364-2313","issn-type":"print"},{"issue":"4","key":"12_40869231","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/j.1365-2265.2011.04227.x","volume":"76","author":"Sakurai","year":"2012","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"7","key":"13_6022624","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1007\/s002689900453","volume":"22","author":"Ito","year":"1998","journal-title":"World journal of surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0364-2313","issn-type":"print"},{"issue":"19","key":"14_16516435","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1001\/jama.1996.03540190047028","volume":"276","author":"Eng","year":"1996","journal-title":"JAMA","ISSN":"https:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"issue":"6","key":"15_30042286","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/j.surg.2007.09.013","volume":"142","author":"Quayle","year":"2007","journal-title":"Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0039-6060","issn-type":"print"},{"issue":"1","key":"16_38412761","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1002\/humu.21385","volume":"32","author":"Frank-Raue","year":"2011","journal-title":"Human mutation","ISSN":"https:\/\/id.crossref.org\/issn\/1059-7794","issn-type":"print"},{"issue":"4","key":"17_18111864","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.jamcollsurg.2003.12.001","volume":"198","author":"Yip","year":"2004","journal-title":"Journal of the American College of Surgeons","ISSN":"https:\/\/id.crossref.org\/issn\/1072-7515","issn-type":"print"},{"issue":"12","key":"18_23100662","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1001\/archsurg.141.12.1199","volume":"141","author":"Asari","year":"2006","journal-title":"Archives of Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0004-0010","issn-type":"print"},{"issue":"9","key":"19_6341182","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1080\/11024159950189320","volume":"165","author":"de Graaf","year":"1999","journal-title":"The European journal of surgery = Acta chirurgica","ISSN":"https:\/\/id.crossref.org\/issn\/1102-4151","issn-type":"print"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/168\/5\/683.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/168\/5\/683.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T11:29:07Z","timestamp":1676374147000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/168\/5\/683\/6659621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":19,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.1530\/eje-12-1106","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}