{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:53:26Z","timestamp":1792173206552,"version":"4.4.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate the association of risk variants for type 2 diabetes (T2D) and hyperglycemia with gestational diabetes (GDM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and methods<\/jats:title><jats:p>Five hundred and thirty-three Finnish women who were diagnosed with GDM and 407 controls with normal glucose tolerance during the pregnancy were genotyped for 69 single-nucleotide polymorphisms (SNPs) which have been previously verified as susceptibility risk variants for T2D and hyperglycemia. All participants underwent an oral glucose tolerance test at the follow-up study after the index pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Risk variants rs10830963 and rs1387153 of<jats:italic>MTNR1B<\/jats:italic>were significantly associated with GDM (odds ratio (OR)=1.62 (95% CI 1.34\u20131.96),<jats:italic>P<\/jats:italic>=4.5\u00d710<jats:sup>\u22127<\/jats:sup>and 1.38 (1.14\u20131.66),<jats:italic>P<\/jats:italic>=7.6\u00d710<jats:sup>\u22124<\/jats:sup>respectively). Both SNPs of<jats:italic>MTNR1B<\/jats:italic>were also significantly associated with elevated fasting glucose level and reduced insulin secretion at follow-up. Additionally, risk variants rs9939609 of<jats:italic>FTO<\/jats:italic>, rs2796441 of<jats:italic>TLE1<\/jats:italic>, rs560887 of<jats:italic>G6PC2<\/jats:italic>, rs780094 of<jats:italic>GCKR<\/jats:italic>, rs7903146 of<jats:italic>TCF7L2<\/jats:italic>and rs11708067 of<jats:italic>ADCY5<\/jats:italic>showed nominally significant associations with GDM (OR range from 1.25 to 1.30).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggests that GDM and T2D share a similar genetic background. Our findings also provide further evidence that risk variants of<jats:italic>MTNR1B<\/jats:italic>are associated with GDM by increasing fasting plasma glucose and decreasing insulin secretion.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-13-0286","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T02:42:37Z","timestamp":1371091357000},"page":"291-297","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":112,"title":["Association of risk variants for type 2 diabetes and hyperglycemia with gestational 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