{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T06:08:37Z","timestamp":1793686117302,"version":"4.5.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Context<\/jats:title><jats:p>Thyroglobulin (Tg) measurement is a major tool for the follow-up of differentiated thyroid cancer (DTC) patients; however, in patients who do not undergo radioactive iodine (RAI) ablation, normal ultrasensitive Tg levels measured under levothyroxine treatment (usTg\/<jats:sc>l<\/jats:sc>-T<jats:sub>4<\/jats:sub>) are not well defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective and design<\/jats:title><jats:p>This single-center retrospective study assessed usTg\/<jats:sc>l<\/jats:sc>-T<jats:sub>4<\/jats:sub> level in 86 consecutive patients treated with total thyroidectomy without RAI ablation for low-risk DTC (<jats:italic>n<\/jats:italic>=77) or for tumors of uncertain malignant potential (TUMP) (<jats:italic>n<\/jats:italic>=9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DTCs were classified as pT1, pT2, and pT3 in 75, 1, and 1 case respectively and pN0, pN1, and pNx in 40, 6, and 31 respectively. Following surgery, ten patients had Tg antibodies (TgAb). Among those without TgAb, the first usTg\/<jats:sc>l<\/jats:sc>-T<jats:sub>4<\/jats:sub> determination obtained at a mean time of 9 months after surgery was \u22640.1\u200ang\/ml in 62% of cases, \u22640.3\u200ang\/ml in 82% of cases, \u22641\u200ang\/ml in 91%, and \u22642\u200ang\/ml in 96% of cases. After a median follow-up of 2.5 years (range: 0.6\u20137.2 years), one patient had persistent disease with an usTg\/<jats:sc>l<\/jats:sc>-T<jats:sub>4<\/jats:sub> at 11\u200ang\/ml and an abnormal neck ultrasonography (US) and two patients had usTg\/<jats:sc>l<\/jats:sc>-T<jats:sub>4<\/jats:sub> level &gt;2\u200ang\/ml (3.9 and 4.9\u200ang\/ml) with a normal neck US. Within the first 2 years following total thyroidectomy without RAI ablation, usTg\/<jats:sc>l<\/jats:sc>-T<jats:sub>4<\/jats:sub> level is \u22642\u200ang\/ml in 96% of the cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After total thyroidectomy, sensitive serum Tg\/<jats:sc>l<\/jats:sc>-T<jats:sub>4<\/jats:sub> level is \u22642\u200ang\/ml in most patients and can be used for patient follow-up.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-13-0386","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T04:08:01Z","timestamp":1376366881000},"page":"689-693","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":64,"title":["Ultrasensitive serum thyroglobulin measurement is useful for the follow-up of patients treated with total thyroidectomy without radioactive iodine ablation"],"prefix":"10.1093","volume":"169","author":[{"given":"C","family":"Nascimento","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Borget","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Troalen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Al Ghuzlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Deandreis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Hartl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Lumbroso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C N","family":"Chougnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Baudin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Schlumberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Leboulleux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"18","key":"1_22064917","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1001\/jama.295.18.2164","volume":"295","author":"Davies","year":"2006","journal-title":"JAMA","ISSN":"https:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"issue":"1","key":"2_32341539","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1530\/EJE-08-0624","volume":"160","year":"2009","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"3","key":"3_39059863","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1089\/thy.2010.0137","volume":"21","author":"Hughes","year":"2011","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"12","key":"4_38485688","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1089\/thy.2010.0178","volume":"20","author":"Tuttle","year":"2010","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"key":"5_46624164","first-page":"1235","volume":"11","year":"2010","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"5","key":"6_41871858","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1210\/jc.2011-2512","volume":"97","year":"2012","journal-title":"Journal of Clinical Endocrinology &amp; 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