{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:40:05Z","timestamp":1790314805116,"version":"4.1.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The number of morbidly obese subjects submitted to bariatric surgery is rising worldwide. In a fraction of patients undergoing gastric bypass (GBP), episodes with late postprandial hypoglycemia (PPHG) develop 1\u20133 years after surgery. The pathogenesis of this phenomenon is not fully understood; meal-induced rapid and exaggerated increases of circulating incretins and insulin appear to be at least partially responsible. Current treatments include low-carbohydrate diets, inhibition of glucose intestinal uptake, reduction of insulin secretion with calcium channel blockers, somatostatin analogs, or diazoxide, a K\n                      <jats:sub>ATP<\/jats:sub>\n                      channel opener. Even partial pancreatectomy has been advocated. In type 2 diabetes, GLP1 analogs have a well-documented effect of stabilizing glucose levels without causing hypoglycemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>We explored GLP1 analogs as open treatment in five consecutive GBP cases seeking medical attention because of late postprandial hypoglycemic symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Glucose measured in connection with the episodes in four of the cases had been 2.7, 2.5, 1.8, and 1.6\u200ammol\/l respectively. The patients consistently described that the analogs eliminated their symptoms, which relapsed in four of the five patients when treatment was reduced\/discontinued. The drug effect was further documented in one case by repeated 24-h continuous glucose measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These open, uncontrolled observations suggest that GLP1 analogs might provide a new treatment option in patients with problems of late PPHG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/eje-13-0504","type":"journal-article","created":{"date-parts":[[2013,10,2]],"date-time":"2013-10-02T00:05:33Z","timestamp":1380672333000},"page":"885-889","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":91,"title":["GLP1 analogs as treatment of postprandial hypoglycemia following gastric bypass surgery: a potential new indication?"],"prefix":"10.1093","volume":"169","author":[{"given":"Niclas","family":"Abrahamsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt Ed\u00e9n","family":"Engstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Sundbom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F Anders","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"14","key":"1_18331449","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1001\/jama.292.14.1724","volume":"292","author":"Buchwald","year":"2004","journal-title":"JAMA","ISSN":"https:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"issue":"10","key":"2_40131906","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1007\/s11605-011-1585-8","volume":"15","author":"Cui","year":"2011","journal-title":"Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract","ISSN":"https:\/\/id.crossref.org\/issn\/1091-255X","issn-type":"print"},{"issue":"2","key":"3_42905246","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000336681","volume":"30","author":"Hammer","year":"2012","journal-title":"Digestive diseases (Basel, Switzerland)","ISSN":"https:\/\/id.crossref.org\/issn\/0257-2753","issn-type":"print"},{"issue":"5","key":"4_38111545","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.jamcollsurg.2010.07.003","volume":"211","author":"Mine","year":"2010","journal-title":"Journal of the American College of Surgeons","ISSN":"https:\/\/id.crossref.org\/issn\/1072-7515","issn-type":"print"},{"key":"5_40347932","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1007\/s00125-010-1798-5","volume":"53","year":"2010","journal-title":"Diabetologia","ISSN":"https:\/\/id.crossref.org\/issn\/0012-186X","issn-type":"print"},{"issue":"2","key":"6_39506672","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.jss.2010.09.047","volume":"167","author":"Rabiee","year":"2011","journal-title":"The Journal of surgical research","ISSN":"https:\/\/id.crossref.org\/issn\/0022-4804","issn-type":"print"},{"issue":"12","key":"7_29959727","doi-asserted-by":"publisher","first-page":"4563","DOI":"10.1210\/jc.2007-2260","volume":"92","author":"Vella","year":"2007","journal-title":"Journal of Clinical Endocrinology &amp; 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