{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:38:44Z","timestamp":1781631524307,"version":"3.54.5"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Tumor-induced osteomalacia is a rare paraneoplastic syndrome characterized by hypophosphatemia and inappropriately normal or low 1,25-dihydroxyvitamin D.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical case<\/jats:title><jats:p>Here, we report a 6-year postoperative follow-up of a patient with oncogenic osteomalacia with a distinctive skeletal manifestation. The latter was characterized by an almost linear lytic lesion of a few millimeters with irregular borders, mainly involving the trabecular compartment but extending into cortical shell, located in the middle third of the right fibula. Six years after tumor resection, a sclerotic repair with a complete recovery was observed. Furthermore, we monitored a striking increase in bone mineral density throughout the observation period, reaching a peak of 73% over basal values at lumbar spine after 2 years; at total femur and radius, the peak was 47.5 and 4.6% respectively, after 4 years from tumor resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We report for the first time that an osteolytic lesion may be part of the skeletal involvement in tumor-induced osteomalacia.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-13-0581","type":"journal-article","created":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T02:28:27Z","timestamp":1382408907000},"page":"K1-K4","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":20,"title":["Six-year follow-up of a characteristic osteolytic lesion in a patient with tumor-induced osteomalacia"],"prefix":"10.1093","volume":"170","author":[{"given":"Sara","family":"Piemonte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Romagnoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Cipriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"De Lucia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Pilotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Diacinti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Pepe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Minisola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"1_46999562","first-page":"R53","volume":"8","year":"2011","journal-title":"Endocrine-Related Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1351-0088","issn-type":"print"},{"key":"2_40075426","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1023\/A:1010006811394","volume":"2","year":"2001","journal-title":"REVIEWS IN ENDOCRINE METABOLIC DISORDERS"},{"issue":"10","key":"3_19404563","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1001\/jama.294.10.1260","volume":"294","author":"Jan de Beur","year":"2005","journal-title":"JAMA","ISSN":"https:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"issue":"1","key":"4_41722364","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00774-011-0340-2","volume":"30","author":"Carpenter","year":"2012","journal-title":"Journal of bone and mineral metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0914-8779","issn-type":"print"},{"issue":"9","key":"5_42452391","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1002\/jbmr.1642","volume":"27","author":"Jiang","year":"2012","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"key":"6_46999563","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bone.2012.11.040","volume":"53","year":"2013","ISSN":"https:\/\/id.crossref.org\/issn\/8756-3282","issn-type":"print"},{"issue":"4","key":"7_15759140","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3346\/jkms.1994.9.4.289","volume":"9","author":"Park","year":"1994","journal-title":"Journal of Korean medical science","ISSN":"https:\/\/id.crossref.org\/issn\/1011-8934","issn-type":"print"},{"issue":"12","key":"8_18345490","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1007\/s00198-003-1521-1","volume":"14","author":"Pedrazzoni","year":"2003","journal-title":"Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA","ISSN":"https:\/\/id.crossref.org\/issn\/0937-941X","issn-type":"print"},{"issue":"10","key":"9_37669658","doi-asserted-by":"publisher","first-page":"4771","DOI":"10.1210\/jc.2010-0502","volume":"95","year":"2010","journal-title":"Journal of Clinical Endocrinology &amp; 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