{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:39:46Z","timestamp":1782877186062,"version":"3.54.5"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The diagnosis of autoimmune diabetes in non-obese adults is based on the detection of glutamic acid decarboxylase autoantibodies (GADA), islet cell antibodies (ICA) and antibodies to tyrosine phosphatase (IA-2A). Zinc transporter 8 (ZnT8) has been identified as a new autoantigen in patients with type 1 diabetes mellitus. The coincidence of autoimmune thyroiditis (AITD) with diabetes is common; therefore, screening of TSH and thyroid peroxidase antibodies (ATPO) is recommended during the diagnosis of diabetes. In this study, we determined whether the occurrence of islet autoantibodies is associated with a positive titre of ATPO in newly diagnosed adult-onset autoimmune diabetic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and methods<\/jats:title><jats:p>The study involved 80 non-obese adults aged 44 (interquartile range (IQR): 37\u201351) years with a BMI of 24.0 (IQR: 22.2\u201326.0) kg\/m<jats:sup>2<\/jats:sup>and new-onset diabetes. The markers of autoimmune diabetes (GADA, ICA, IA-2A and ZnT8A), TSH and thyroid peroxidase antibodies (ATPO) were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the study population, 70% (<jats:italic>n<\/jats:italic>=56) of the subjects were positive for at least one of the four assessed markers of autoimmune diabetes (83.9% GADA, 62.5% ICA, 42.8% IA-2A and 33% ZnT8A) and 37.5% of the subjects were positive for ATPO. The ZnT8A-positive subjects had higher ATPO titres than the ZnT8A-negative subjects (172.7 (IQR: 0.36\u2013410.4) vs 92.4 (IQR: 0\u201323.7) IU\/ml,<jats:italic>P<\/jats:italic>=0.001). Based on the assessed islet autoantibodies, the occurrence of positive ZnT8A and GADA was found to be related to a positive titre of ATPO using logistic regression (OR=5.48, 95% CI: 1.65\u201318.14,<jats:italic>P<\/jats:italic>=0.006 and OR=3.42, 95% CI: 1.09\u201310.71,<jats:italic>P<\/jats:italic>=0.03 respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In non-obese adults with new-onset diabetes, the presence of GADA and especially ZnT8 autoantibodies increases the risk of AITD.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-13-0901","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T02:07:14Z","timestamp":1391134034000},"page":"651-658","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":16,"title":["Are zinc transporter type 8 antibodies a marker of autoimmune thyroiditis in non-obese adults with new-onset diabetes?"],"prefix":"10.1093","volume":"170","author":[{"given":"Anita","family":"Rogowicz-Frontczak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Zozuli\u0144ska-Zi\u00f3\u0142kiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Litwinowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Nied\u017awiecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystyna","family":"Wyka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogna","family":"Wierusz-Wysocka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"7","key":"1_6097608","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S","volume":"15","author":"Alberti","year":"1998","journal-title":"Diabetic medicine : a journal of the British Diabetic Association","ISSN":"https:\/\/id.crossref.org\/issn\/0742-3071","issn-type":"print"},{"key":"2_47569926","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1023\/A:1025148211587","volume":"4","year":"2003","journal-title":"REVIEWS IN ENDOCRINE METABOLIC DISORDERS"},{"issue":"7","key":"3_16015391","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.2337\/diacare.18.7.1050","volume":"18","author":"Zimmet","year":"1995","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"issue":"8","key":"4_11252424","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.2337\/diacare.24.8.1460","volume":"24","author":"Pozzilli","year":"2001","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"issue":"1","key":"5_10708755","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2337\/diabetes.48.1.150","volume":"48","author":"Tuomi","year":"1999","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"issue":"1","key":"6_17958535","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1196\/annals.1288.060","volume":"1005","author":"MARUYAMA","year":"2003","journal-title":"Annals of the New York Academy of Sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0077-8923","issn-type":"print"},{"key":"7_47569927","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.diabet.2009.07.004","volume":"36","year":"2010","journal-title":"DIABETES METABOLISM"},{"issue":"11","key":"8_19599243","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1007\/s00125-005-1960-7","volume":"48","author":"Fourlanos","year":"2005","journal-title":"Diabetologia","ISSN":"https:\/\/id.crossref.org\/issn\/0012-186X","issn-type":"print"},{"issue":"1","key":"9_35682701","doi-asserted-by":"publisher","first-page":"104","DOI":"10.2337\/dc08-2305","volume":"33","year":"2010","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"issue":"9","key":"10_11318110","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1053\/meta.2001.25654","volume":"50","author":"Juneja","year":"2001","journal-title":"Metabolism: clinical and experimental","ISSN":"https:\/\/id.crossref.org\/issn\/0026-0495","issn-type":"print"},{"issue":"6","key":"11_17071695","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.2337\/diabetes.51.6.1754","volume":"51","author":"Borg","year":"2002","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"issue":"4","key":"12_19401292","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s10534-005-3687-9","volume":"18","author":"Chimienti","year":"2005","journal-title":"Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0966-0844","issn-type":"print"},{"key":"13_46310107","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1399-5448.2012.00916.x","volume":"14","year":"2013","journal-title":"Pediatric diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/1399-543X","issn-type":"print"},{"issue":"2","key":"14_18647650","doi-asserted-by":"crossref","first-page":"496","DOI":"10.2337\/diacare.28.2.496","volume":"28","author":"Pinto","year":"2005","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"issue":"10","key":"15_43351132","doi-asserted-by":"publisher","first-page":"3759","DOI":"10.1210\/jc.2012-2037","volume":"97","year":"2012","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"4","key":"16_37544151","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1530\/EJE-10-0427","volume":"163","year":"2010","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"5","key":"17_39676629","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1111\/j.1365-2265.2011.03976.x","volume":"74","author":"Jin","year":"2011","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"key":"18_47569928","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1055\/s-0032-1308979","volume":"120","year":"2012","journal-title":"EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY DIABETES"},{"issue":"4","key":"19_18807420","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1007\/s00125-005-1690-x","volume":"48","author":"Davis","year":"2005","journal-title":"Diabetologia","ISSN":"https:\/\/id.crossref.org\/issn\/0012-186X","issn-type":"print"},{"issue":"4","key":"20_18807445","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s00125-005-1691-9","volume":"48","author":"Bottazzo","year":"2005","journal-title":"Diabetologia","ISSN":"https:\/\/id.crossref.org\/issn\/0012-186X","issn-type":"print"},{"key":"21_47569929","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3109\/08916934.2011.604658","volume":"45","year":"2012","journal-title":"Autoimmunity","ISSN":"https:\/\/id.crossref.org\/issn\/0891-6934","issn-type":"print"},{"issue":"1","key":"22_6114523","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1530\/eje.0.1390044","volume":"139","author":"Chang","year":"1998","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"4","key":"23_18761315","doi-asserted-by":"crossref","first-page":"850","DOI":"10.2337\/diacare.28.4.850","volume":"28","author":"Barker","year":"2005","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"issue":"8","key":"24_17168929","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.2337\/diacare.25.8.1346","volume":"25","author":"Kordonouri","year":"2002","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"issue":"7","key":"25_16278094","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.1210\/jc.81.7.2559","volume":"81","author":"Huang","year":"1996","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"1","key":"26_17689589","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1046\/j.1365-2249.2003.02205.x","volume":"133","author":"Kucera","year":"2003","journal-title":"Clinical and experimental immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9104","issn-type":"print"},{"key":"27_47569930","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4239\/wjd.v4.i5.227","volume":"4","year":"2013","journal-title":"WORLD JOURNAL OF DIABETES"},{"issue":"1","key":"28_14662633","doi-asserted-by":"publisher","first-page":"80","DOI":"10.2337\/diab.43.1.80","volume":"43","author":"Kawasaki","year":"1994","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"key":"29_47569931","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1007\/s00125-013-2934-9","volume":"56","year":"2013","journal-title":"Diabetologia","ISSN":"https:\/\/id.crossref.org\/issn\/0012-186X","issn-type":"print"},{"issue":"7","key":"30_42267479","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1507\/endocrj.EJ12-0069","volume":"59","author":"Kawasaki","year":"2012","journal-title":"Endocrine journal","ISSN":"https:\/\/id.crossref.org\/issn\/0918-8959","issn-type":"print"},{"issue":"6","key":"31_33389292","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.numecd.2008.09.004","volume":"19","author":"Murgia","year":"2009","journal-title":"Nutrition, metabolism, and cardiovascular diseases : NMCD","ISSN":"https:\/\/id.crossref.org\/issn\/0939-4753","issn-type":"print"},{"issue":"11","key":"32_19599246","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1007\/s00125-005-1954-5","volume":"48","author":"Gale","year":"2005","journal-title":"Diabetologia","ISSN":"https:\/\/id.crossref.org\/issn\/0012-186X","issn-type":"print"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/170\/4\/651.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/170\/4\/651.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:30:27Z","timestamp":1676392227000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/170\/4\/651\/6667995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":32,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/eje-13-0901","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4]]}}}