{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:26:34Z","timestamp":1785939994362,"version":"3.56.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Hyperthyroidism in neonates born to mothers with Graves' disease (GD) can be associated with significant morbidity and mortality, but is still overlooked by clinicians. Management of neonatal hyperthyroidism would be improved by a better understanding of the predictive factors involved. The aim of this study was to evaluate the course of thyroid function and clinical outcomes during the first postnatal month in babies born to mothers with GD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty-eight neonates born to mothers with GD were managed from birth and divided into three groups based on thyrotropin receptor antibody (TRAb) and anti-thyroid drug (ATD) status in the mother: TRAb<jats:sup>\u2212ve<\/jats:sup>\/ATD<jats:sup>\u2212ve<\/jats:sup>,<jats:italic>n<\/jats:italic>=27; TRAb<jats:sup>\u2212ve<\/jats:sup>\/ATD<jats:sup>+<\/jats:sup><jats:sup>ve<\/jats:sup>,<jats:italic>n<\/jats:italic>=8; and TRAb<jats:sup>+ve<\/jats:sup>\/ATD<jats:sup>+ve<\/jats:sup>,<jats:italic>n<\/jats:italic>=33. The main outcome measures were clinical examination, thyroid function tests (TSH, free thyroxine (FT<jats:sub>4<\/jats:sub>), free triiodothyronine, and TRAb), echocardiography, thyroid ultrasonography, and bone maturation assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>None of the infants born to TRAb<jats:sup>\u2212ve<\/jats:sup>mothers with GD developed neonatal hyperthyroidism. Of the 33 TRAb<jats:sup>+ve<\/jats:sup>\/ATD<jats:sup>+ve<\/jats:sup>neonates, 24 (72.7%) had positive TRAb on cord blood assays, and seven of these developed neonatal hyperthyroidism. FT<jats:sub>4<\/jats:sub>elevation between days 3 and 7 but not at birth was predictive of the development of hyperthyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TRAb status should be checked in the third trimester in mothers with GD and on cord blood in their neonates; if positive, it indicates a high risk of neonatal hyperthyroidism. FT<jats:sub>4<\/jats:sub>measurement at birth should be repeated between days 3 and 5 (and by day 7 at the latest); rapid FT<jats:sub>4<\/jats:sub>elevation during the first postnatal week is predictive of hyperthyroidism and warrants ATD therapy.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-13-0994","type":"journal-article","created":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T05:54:23Z","timestamp":1395899663000},"page":"855-862","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":85,"title":["Management of neonates born to women with Graves' disease: a cohort study"],"prefix":"10.1093","volume":"170","author":[{"given":"Alix","family":"Besan\u00e7on","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Beltrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Le Gac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Luton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Polak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"2","key":"1_9966696","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1089\/thy.1992.2.155","volume":"2","author":"McKenzie","year":"1992","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"12","key":"2_6299370","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1089\/thy.1998.8.1171","volume":"8","author":"Polak","year":"1998","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"key":"3_47893923","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.beem.2004.03.009","volume":"18","year":"2004","journal-title":"BEST PRACTICE RESEARCH CLINICAL ENDOCRINOLOGY METABOLISM"},{"issue":"6","key":"4_18219927","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.jpeds.2004.02.021","volume":"144","author":"Simoneau-Roy","year":"2004","journal-title":"The Journal of pediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3476","issn-type":"print"},{"issue":"2","key":"5_8169513","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0022-3476(80)80487-2","volume":"97","author":"Daneman","year":"1980","journal-title":"The Journal of pediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3476","issn-type":"print"},{"issue":"3","key":"6_13557073","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1055\/s-2007-999957","volume":"2","author":"Neal","year":"1985","journal-title":"American journal of perinatology","ISSN":"https:\/\/id.crossref.org\/issn\/0735-1631","issn-type":"print"},{"issue":"4","key":"7_28834171","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1515\/JPEM.2007.20.4.535","volume":"20","author":"Zuppa","year":"2007","journal-title":"The Journal of pediatric endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0334-018X","issn-type":"print"},{"issue":"4","key":"8_5860180","first-page":"338","volume":"58","author":"Polak","year":"1997","journal-title":"Annales d'endocrinologie","ISSN":"https:\/\/id.crossref.org\/issn\/0003-4266","issn-type":"print"},{"issue":"9","key":"9_17809024","doi-asserted-by":"publisher","first-page":"4175","DOI":"10.1210\/jc.2003-030522","volume":"88","author":"Singh","year":"2003","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"8","key":"10_10913392","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1056\/NEJM199908193410801","volume":"341","author":"Haddow","year":"1999","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"3","key":"11_17767808","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1046\/j.1365-2265.2003.01822.x","volume":"59","author":"Pop","year":"2003","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"2","key":"12_44927375","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1210\/jc.2012-3572","volume":"98","year":"2013","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"1","key":"13_32134491","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1530\/EJE-08-0663","volume":"160","year":"2009","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"10","key":"14_40416936","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1089\/thy.2011.0087","volume":"21","author":"Stagnaro-Green","year":"2011","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"8","key":"15_43334371","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1210\/jc.2011-2803","volume":"97","author":"De Groot","year":"2012","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"16_47893924","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4274\/Jcrpe.778","volume":"5","year":"2013","journal-title":"JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY"},{"issue":"11","key":"17_19604591","doi-asserted-by":"publisher","first-page":"6093","DOI":"10.1210\/jc.2004-2555","volume":"90","year":"2005","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"18_47893925","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/uog.6315","volume":"33","year":"2009","journal-title":"ULTRASOUND IN OBSTETRICS GYNECOLOGY"},{"issue":"5","key":"19_21868538","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1159\/000092454","volume":"65","author":"Polak","year":"2006","journal-title":"Hormone research","ISSN":"https:\/\/id.crossref.org\/issn\/0301-0163","issn-type":"print"},{"issue":"1","key":"21_40036487","doi-asserted-by":"publisher","first-page":"e232","DOI":"10.1542\/peds.2009-3244","volume":"128","year":"2011","journal-title":"Pediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/0031-4005","issn-type":"print"},{"issue":"12","key":"22_36831059","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1556\/OH.2010.28757","volume":"151","author":"Szaloczi","year":"2010","journal-title":"Orvosi hetilap","ISSN":"https:\/\/id.crossref.org\/issn\/0030-6002","issn-type":"print"},{"issue":"1-2","key":"23_11036225","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0009-8981(00)00385-5","volume":"304","author":"Massart","year":"2001","journal-title":"Clinica Chimica Acta","ISSN":"https:\/\/id.crossref.org\/issn\/1873-3492","issn-type":"print"},{"issue":"17","key":"24_10511060","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1056\/NEJM200010263431707","volume":"343","author":"Weetman","year":"2000","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"11","key":"25_9244646","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/j.1471-0528.1990.tb02472.x","volume":"97","author":"Clavel","year":"1990","journal-title":"British journal of obstetrics and gynaecology","ISSN":"https:\/\/id.crossref.org\/issn\/0306-5456","issn-type":"print"},{"issue":"5","key":"26_46329799","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1177\/000456320103800509","volume":"38","author":"Guibourdenche","year":"2001","journal-title":"Annals of Clinical Biochemistry: An international journal of biochemistry in medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0004-5632","issn-type":"print"},{"issue":"2","key":"27_9933448","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/BF02011305","volume":"22","author":"Ueda","year":"1992","journal-title":"Pediatric radiology","ISSN":"https:\/\/id.crossref.org\/issn\/0301-0449","issn-type":"print"},{"issue":"6","key":"28_11188670","doi-asserted-by":"crossref","first-page":"613","DOI":"10.7863\/jum.2001.20.6.613","volume":"20","author":"Ranzini","year":"2001","journal-title":"Journal of Ultrasound in Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0278-4297","issn-type":"print"},{"issue":"1","key":"29_17689754","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1530\/eje.0.1490001","volume":"149","author":"Wasniewska","year":"2003","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"2","key":"30_16908707","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1210\/jc.87.2.557","volume":"87","author":"Olivieri","year":"2002","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"31_47893926","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/1471-2393-12-165","volume":"12","year":"2012","journal-title":"BMC PREGNANCY AND CHILDBIRTH"},{"key":"32_47893927","first-page":"192","volume":"30","year":"2008","journal-title":"LA PEDIATRIA MEDICA E CHIRURGICA"},{"issue":"6","key":"33_6298028","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1530\/eje.0.1390584","volume":"139","author":"Laurberg","year":"1998","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"2","key":"34_16237878","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/S0022-3476(96)70405-5","volume":"128","author":"Skuza","year":"1996","journal-title":"The Journal of pediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3476","issn-type":"print"},{"issue":"1","key":"35_38369006","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1507\/endocrj.K10E-123","volume":"58","author":"Hamada","year":"2011","journal-title":"Endocrine journal","ISSN":"https:\/\/id.crossref.org\/issn\/0918-8959","issn-type":"print"},{"issue":"11","key":"36_18511396","doi-asserted-by":"publisher","first-page":"5314","DOI":"10.1210\/jc.2004-0869","volume":"89","author":"Williams","year":"2004","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"10","key":"37_11426628","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1515\/CCLM.2001.158","volume":"39","author":"Elmlinger","year":"2001","journal-title":"Clinical chemistry and laboratory medicine : CCLM \/ FESCC","ISSN":"https:\/\/id.crossref.org\/issn\/1434-6621","issn-type":"print"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/170\/6\/855.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/170\/6\/855.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:30:34Z","timestamp":1676392234000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/170\/6\/855\/6661622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":36,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1530\/eje-13-0994","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}