{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:20:50Z","timestamp":1780086050200,"version":"3.54.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>There is evidence suggesting a strong genetic background of polycystic ovary syndrome (PCOS). We aim to study the metabolic and endocrine characteristics of PCOS women with and without a family history (FHx) of type 2 diabetes mellitus (T2DM) and PCOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross-sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed the association of T2DM FHx and PCOS FHx with metabolic and endocrine parameters in 714 PCOS women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A positive FHx of T2DM and PCOS were prevalent in 36.8 and 21.4% of PCOS women respectively. We found an independent association of T2DM FHx with central fat accumulation, obesity, prediabetes, metabolic syndrome (MS), insulin resistance, low HDL and elevated blood pressure (<jats:italic>P<\/jats:italic>&lt;0.05 for all). PCOS FHx was independently associated with prediabetes (<jats:italic>P<\/jats:italic>&lt;0.05). We observed an independent association of PCOS FHx with clinical and biochemical hyperandrogenism (<jats:italic>P<\/jats:italic>&lt;0.05 for all), whereas there was no independent association of T2DM FHx with hyperandrogenism. PCOS women with a positive FHx of both T2DM and PCOS had an adverse metabolic and endocrine profile including a linear increase in risk of obesity, central fat accumulation, MS, prediabetes and low HDL (<jats:italic>P<\/jats:italic>&lt;0.05 for all).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that the assessment of FHx might allow risk stratification of PCOS women, which is important considering the high prevalence of PCOS.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-13-1035","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T05:34:16Z","timestamp":1393911256000},"page":"727-739","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":32,"title":["Influence of a positive family history of both type 2 diabetes and PCOS on metabolic and endocrine parameters in a large cohort of PCOS women"],"prefix":"10.1093","volume":"170","author":[{"given":"Elisabeth","family":"Lerchbaum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Schwetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albrecht","family":"Giuliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Obermayer-Pietsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"10","key":"1_43040480","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.1093\/humrep\/des232","volume":"27","year":"2012","journal-title":"Human Reproduction","ISSN":"https:\/\/id.crossref.org\/issn\/0268-1161","issn-type":"print"},{"key":"2_47718868","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1023\/B:REMD.0000016125.05878.96","volume":"5","year":"2004","journal-title":"REVIEWS IN ENDOCRINE AND METABOLIC DISORDERS"},{"key":"3_46001194","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1007\/s00125-012-2638-6","volume":"55","year":"2012","journal-title":"Diabetologia","ISSN":"https:\/\/id.crossref.org\/issn\/0012-186X","issn-type":"print"},{"issue":"2","key":"4_30903222","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S1043-2760(98)00021-6","volume":"9","author":"Kahsar-Miller","year":"1998","journal-title":"Trends in endocrinology and metabolism: TEM","ISSN":"https:\/\/id.crossref.org\/issn\/1043-2760","issn-type":"print"},{"issue":"2","key":"5_39931092","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1210\/er.2004-0004","volume":"26","year":"2005","journal-title":"Endocrine Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0163-769X","issn-type":"print"},{"issue":"12","key":"6_18756862","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1056\/NEJMra041536","volume":"352","author":"Ehrmann","year":"2005","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"7-8","key":"7_35210295","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1007\/s00508-009-1162-2","volume":"121","author":"Wehr","year":"2009","journal-title":"Wiener klinische Wochenschrift","ISSN":"https:\/\/id.crossref.org\/issn\/0043-5325","issn-type":"print"},{"issue":"6","key":"8_39607254","doi-asserted-by":"publisher","first-page":"E986","DOI":"10.1210\/jc.2011-0031","volume":"96","year":"2011","journal-title":"Journal of Clinical Endocrinology &amp; 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