{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T21:18:15Z","timestamp":1784409495695,"version":"3.55.0"},"reference-count":135,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>Paragangliomas (PGLs) are rare vascular, neuroendocrine tumors of paraganglia, which are associated with either sympathetic tissue in adrenal (pheochromocytomas (PCCs)) and extraadrenal (sympathetic paraganglioma (sPGLs)) locations or parasympathetic tissue of the head and neck paragangliomas (HNPGLs). As HNPGLs are usually benign and most tumors grow slowly, a wait-and-scan policy is often advised. However, their location in the close proximity to cranial nerves and vasculature may result in considerable morbidity due to compression or infiltration of the adjacent structures, necessitating balanced decisions between a wait-and-see policy and active treatment. The main treatment options for HNPGL are surgery and radiotherapy. In contrast to HNPGLs, the majority of sPGL\/PCCs produces catecholamines, in advanced cases resulting in typical symptoms and signs such as palpitations, headache, diaphoresis, and hypertension. The state-of-the-art diagnosis and localization of sPGL\/PCCs are based on measurement of plasma and\/or 24-h urinary excretion of (fractionated) metanephrines and methoxytyramine (MT). sPGL\/PCCs can subsequently be localized by anatomical (computed tomography and\/or magnetic resonance imaging) and functional imaging studies (<jats:sup>123<\/jats:sup>I-metaiodobenzylguanidine-scintigraphy,<jats:sup>111<\/jats:sup>In-pentetreotide scintigraphy, or positron emission tomography with radiolabeled dopamine or dihydroxyphenylalanine). Although most PGL\/PCCs are benign, factors such as genetic background, tumor size, tumor location, and high MT levels are associated with higher rates of metastatic disease. Surgery is the only curative treatment. Treatment options for patients with metastatic disease are limited. PGL\/PCCs have a strong genetic background, with at least one-third of all cases linked with germline mutations in 11 susceptibility genes. As genetic testing becomes more widely available, the diagnosis of PGL\/PCCs will be made earlier due to routine screening of at-risk patients. Early detection of a familial PGL allows early detection of potentially malignant PGLs and early surgical treatment, reducing the complication rates of this operation.<\/jats:p>","DOI":"10.1530\/eje-14-0396","type":"journal-article","created":{"date-parts":[[2014,7,26]],"date-time":"2014-07-26T00:22:05Z","timestamp":1406334125000},"page":"R231-R243","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":50,"title":["MANAGEMENT OF ENDOCRINE DISEASE: Clinical management of paragangliomas"],"prefix":"10.1093","volume":"171","author":[{"given":"Eleonora P","family":"Corssmit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes A","family":"Romijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"5","key":"3_34068852","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1210\/jc.2008-2419","volume":"94","year":"2009","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"6","key":"4_37732945","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1097\/MPA.0b013e3181ebb4f0","volume":"39","author":"Chen","year":"2010","journal-title":"Pancreas","ISSN":"https:\/\/id.crossref.org\/issn\/0885-3177","issn-type":"print"},{"issue":"6","key":"5_10620257","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1111\/j.1445-5994.2000.tb04358.x","volume":"30","author":"McNeil","year":"2000","journal-title":"Australian and New Zealand journal of medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0004-8291","issn-type":"print"},{"issue":"12","key":"6_13043284","first-page":"802","volume":"58","author":"Beard","year":"1983","journal-title":"Mayo Clinic Proceedings","ISSN":"https:\/\/id.crossref.org\/issn\/0025-6196","issn-type":"print"},{"issue":"9486","key":"7_19341577","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/S0140-6736(05)67139-5","volume":"366","author":"Lenders","year":"2005","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"issue":"5","key":"8_34183434","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1210\/jc.2008-2756","volume":"94","year":"2009","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"5","key":"9_41965622","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1055\/s-0031-1301302","volume":"44","author":"Gimenez-Roqueplo","year":"2012","journal-title":"Hormone and metabolic research. 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