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However, spironolactone (FDA pregnancy category C) might lead to undervirilization of male infants due to the anti-androgenic effects. Although data in the literature are very limited, treatment with spironolactone is not recommended. Eplerenone (FDA pregnancy category B) is a selective MRA without anti-androgenic potential. If MRA treatment is required in pregnancy, eplerenone appears to be a safe and effective alternative, although symptomatic treatment with approved antihypertensive drugs and supplementation with potassium is the first choice. In case of aldosterone-producing adenoma, laparoscopic adrenalectomy is a therapeutic option in the second trimester of pregnancy.<\/jats:p>","DOI":"10.1530\/eje-14-0444","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T03:14:07Z","timestamp":1409195647000},"page":"R23-R30","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":81,"title":["PROGRESS IN PRIMARY ALDOSTERONISM: Mineralocorticoid receptor antagonists and management of primary aldosteronism in pregnancy"],"prefix":"10.1093","volume":"172","author":[{"given":"Anna","family":"Riester","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"1_49234903","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1042\/CS20130455","volume":"126","year":"2014","journal-title":"Clinical Science","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9287","issn-type":"print"},{"issue":"2","key":"2_14179735","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1210\/jcem-65-2-349","volume":"65","author":"DERKX","year":"1987","journal-title":"Journal of Clinical Endocrinology &amp; 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