{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:07:59Z","timestamp":1762430879754},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Primary hyperparathyroidism (PHPT) is one of the most frequently diagnosed endocrine disorders, but few studies have focused on hospital management of the disease in Europe. We investigated the frequency of hospital admission for diagnosis and surgical treatment of PHPT in Italy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective study was conducted for investigating the hospital care for PHPT in Italy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrieved data from the \u2018Record of Hospital Discharge\u2019 of the Italian Health Ministry, from 2006 to 2011, and analyzed the codes corresponding to PHPT-related diagnoses and surgical procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 46\u200a275 hospitalization episodes for PHPT were identified during the entire period (69% in women and 31% in men; mean age 63.3\u00b139.8 years). Patients' mean age significantly increased during the years (<jats:italic>P<\/jats:italic>&lt;0.001). The mean length of stay was 8.2\u00b110.5 days (28% of the episodes requiring &lt;3 days of stay). Admissions for surgical procedures were 12\u200a457 accounting for 26.9% of the total hospitalizations. There was a trend to a significant increase in the percentage of surgery (<jats:italic>P<\/jats:italic>&lt;0.05). The mean hospitalization rate for PHPT was 12.9\/100\u200a000 inhabitants per year and the trend showed a significant decrease during the period of 2006\u20132011 (<jats:italic>P<\/jats:italic>&lt;0.0001). The mean hospitalization rate for PHPT surgery was 3.65\/100\u200a000 per year, which significantly increased over time (<jats:italic>P<\/jats:italic>&lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PHPT considerably influences the Italian Hospital healthcare system. We observed a tendency to a decrease in the frequency of hospitalization during the period of 2006\u20132011, most probably because of economic issues, a concomitant increased age of patients, and, interestingly, also a progressive increase in the percentage of surgical treatment among patients admitted for PHPT.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-14-0493","type":"journal-article","created":{"date-parts":[[2014,7,12]],"date-time":"2014-07-12T04:05:35Z","timestamp":1405137935000},"page":"481-487","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":10,"title":["Hospital care for primary hyperparathyroidism in Italy: a 6-year register-based study"],"prefix":"10.1093","volume":"171","author":[{"given":"Cristiana","family":"Cipriani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Carnevale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Biamonte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Piemonte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Pepe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Nieddu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P","family":"Bilezikian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Minisola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"issue":"6","key":"1_16707225","doi-asserted-by":"crossref","first-page":"433","DOI":"10.7326\/0003-4819-126-6-199703150-00003","volume":"126","author":"Wermers","year":"1997","journal-title":"Annals of Internal Medicine","ISSN":"http:\/\/id.crossref.org\/issn\/0003-4819","issn-type":"print"},{"key":"2_48560094","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jocd.2012.11.009","volume":"16","year":"2013","journal-title":"Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry","ISSN":"http:\/\/id.crossref.org\/issn\/1094-6950","issn-type":"print"},{"issue":"1","key":"3_21491859","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1359\/JBMR.050910","volume":"21","author":"Wermers","year":"2006","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","ISSN":"http:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"issue":"7","key":"4_45840045","doi-asserted-by":"publisher","first-page":"2734","DOI":"10.1210\/jc.2013-1300","volume":"98","year":"2013","journal-title":"Journal of Clinical Endocrinology &amp; 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