{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:59:33Z","timestamp":1791381573415,"version":"4.3.3"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Prevalence of GH deficiency (GHD) caused by traumatic brain injury (TBI) is highly variable. Short-term studies show improvement in quality of life (QoL) during GH replacement (GHR), but long-term data are lacking. The aim of this study was to analyse the clinical characteristics of post-traumatic hypopituitarism and the QoL effects of long-term GHR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design\/methods<\/jats:title><jats:p>Pfizer International Metabolic Database patients with GHD caused by TBI and by non-functioning pituitary adenoma (NFPA) were compared regarding: clinical characteristics at baseline and 1-year of GHR, and QoL response up to 8-years of GHR (QoL-AGHDA total scores and dimensions) in relationship with country-specific norms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TBI patients compared with NFPA patients were younger, diagnosed with GHD 2.4 years later after primary disease onset (<jats:italic>P<\/jats:italic>&lt;0.0001), had a higher incidence of isolated GHD, higher GH peak, a more favourable metabolic profile and worse QoL, were shorter by 0.9\u200acm (1.8\u200acm when corrected for age and gender; <jats:italic>P<\/jats:italic>=0.004) and received higher GH dose (mean difference: 0.04\u200amg\/day <jats:italic>P<\/jats:italic>=0.006). In TBI patients, 1-year improvement in QoL was greater than in NFPA (change in QoL-AGHDA score 5.0 vs 3.5, respectively, <jats:italic>P<\/jats:italic>=0.04) and was sustained over 8 years. In TBI patients, socialisation normalised after 1 year of GHR, self-confidence and tenseness after 6 years and no normalisation of tiredness and memory was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with NFPA, TBI patients presented biochemically with less severe hypopituitarism and worse QoL scores. GHR achieved clinically relevant, long-term benefit in QoL.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-14-0654","type":"journal-article","created":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T05:04:57Z","timestamp":1421125497000},"page":"371-381","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":63,"title":["GH deficiency after traumatic brain injury: improvement in quality of life with GH therapy: analysis of the KIMS database"],"prefix":"10.1093","volume":"172","author":[{"given":"Chris J","family":"Gardner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders 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