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However, the number of pregnancies reporting such experience is about sevenfold greater for bromocriptine. Tumor growth causing significant symptoms and requiring intervention has been reported to occur in 2.4% of those with microadenomas, 21% in those with macroadenomas without prior surgery or irradiation, and 4.7% of those with macroadenomas with prior surgery or irradiation. Visual fields should be assessed periodically during gestation in women with macroadenomas. If significant tumor growth occurs, most patients respond well to reinstitution of the dopamine agonist. Delivery of the baby and placenta can also be considered if the pregnancy is sufficiently advanced. Transsphenoidal debulking of the tumor is rarely necessary.<\/jats:p>","DOI":"10.1530\/eje-14-0848","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T05:50:53Z","timestamp":1427262653000},"page":"R205-R213","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":153,"title":["ENDOCRINOLOGY IN PREGNANCY: Management of the pregnant patient with a prolactinoma"],"prefix":"10.1093","volume":"172","author":[{"given":"Mark E","family":"Molitch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"5","key":"1_13318227","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1210\/jcem-59-5-941","volume":"59","author":"SAUDER","year":"1984","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"2_13313400","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1365-2265.1984.tb03467.x","volume":"21","author":"Winters","year":"1984","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"key":"3_50058570","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/jne.12223","volume":"26","year":"2014","journal-title":"Journal of neuroendocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0953-8194","issn-type":"print"},{"issue":"5978","key":"4_12957237","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1136\/bmj.3.5978.274","volume":"3","author":"Glass","year":"1975","journal-title":"BMJ","ISSN":"https:\/\/id.crossref.org\/issn\/0959-8138","issn-type":"print"},{"issue":"7","key":"5_10886502","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1210\/me.13.7.1084","volume":"13","author":"Feltus","year":"1999","journal-title":"Molecular Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0888-8809","issn-type":"print"},{"issue":"9","key":"6_14133154","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1073\/pnas.84.9.2643","volume":"84","author":"Ramasharma","year":"1987","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"6","key":"7_8651972","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1210\/jcem-54-6-1246","volume":"54","author":"DEMURA","year":"1982","journal-title":"Journal of Clinical Endocrinology &amp; 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