{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T16:21:04Z","timestamp":1774282864807,"version":"3.50.1"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the relationship between the lactonase activities and status of paraoxonase 1 (PON1) and its association with the <jats:italic>PON1<\/jats:italic> genetic polymorphisms in women with polycystic ovarian syndrome (PCOS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A case\u2013control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 455 PCOS patients and 441 control women were included in this study. The lactonase activities and concentrations of PON1 were assayed using 5-thiobutyl butyrolactone (TBBL) and 7-<jats:italic>O<\/jats:italic>-diethylphosphoryl-3-cyano-4-methyl-7-hydroxycoumarin (DEPCyMC) respectively. A normalized lactonase activity (NLA) was estimated based on the ratio of TBBLase:DEPCyMCase activity. The <jats:italic>PON1<\/jats:italic> genotypes, serum malondialdehyde (MDA) levels and total antioxidant capacity were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The lactonase activities and levels of PON1 were higher in PCOS patients than in the control women. However, the NLA did not significantly differ between groups. The <jats:italic>\u2212108C<\/jats:italic><jats:italic>\u2192<\/jats:italic><jats:italic>T<\/jats:italic> variation of the <jats:italic>PON1<\/jats:italic> gene showed decreased lactonase activities and levels of PON1 in a genotype-dependent manner (CC&gt;CT&gt;TT); the <jats:italic>192Q<\/jats:italic><jats:italic>\u2192<\/jats:italic><jats:italic>R<\/jats:italic> variation of the <jats:italic>PON1<\/jats:italic> gene showed increased PON1 lactonase activities and NLA; and the <jats:italic>55L<\/jats:italic><jats:italic>\u2192<\/jats:italic><jats:italic>M<\/jats:italic> variation of the <jats:italic>PON1<\/jats:italic> gene showed decreased lactonase activities and levels of PON1 but an increased NLA. A multivariable regression analysis showed that the <jats:italic>\u2212108C\/T<\/jats:italic>, <jats:italic>192Q<\/jats:italic><jats:italic>\/<\/jats:italic><jats:italic>R<\/jats:italic>, and <jats:italic>55L\/M<\/jats:italic> variations of the <jats:italic>PON1<\/jats:italic> gene, serum apolipoprotein A1, and MDA levels were significant predictors of PON1 lactonase activity, PON1 level, and NLA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The serum lactonase activities and concentrations of PON1 are increased in PCOS patients. The increased oxidative stress and the <jats:italic>\u2212108C\/T<\/jats:italic>, <jats:italic>192Q\/R<\/jats:italic>, and <jats:italic>55L\/M<\/jats:italic> genetic polymorphisms of <jats:italic>PON1<\/jats:italic> may be associated with these changes.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-14-0863","type":"journal-article","created":{"date-parts":[[2015,1,10]],"date-time":"2015-01-10T05:26:30Z","timestamp":1420867590000},"page":"391-402","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":24,"title":["Lactonase activity and status of paraoxonase 1 in Chinese women with polycystic ovarian 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