{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:28:49Z","timestamp":1793273329859,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Injectable testosterone undecanoate (TU) was marketed within the last decade, but its complications in routine clinical practice are not well defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and methods<\/jats:title>\n                    <jats:p>Prospective observational study of consecutive TU injections in an Andrology Clinic to estimate the incidence of i) immediate cough\/syncope due to pulmonary oil microembolisation (POME), ii) post-injection haematoma and iii) the prevalence of secondary polycythaemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 3022 injections given to 347 patients over 3.5 years, POME was observed after 56 injections (66% mild, 19% severe; 40% with onset before injection completed) in 43 patients. The incidence of 19 (95% CI 14\u201324) per 1000 injections did not differ between three experienced nurse injectors, but recurrences were more frequent than by chance. No post-injection haematoma was reported including after 269 injections to men taking antiplatelet, anticoagulant or both drugs (upper 95% confidence limit 1%) with 56 not withholding drugs prior to TU administration (upper 95% confidence limit 5.4%). Mean haematocrit was 0.44\u00b10.04 (\n                      <jats:sc>s.d.<\/jats:sc>\n                      ) with 25 (7%) &gt;0.50, 14 (4%) &gt;0.52 and 3 (1%) &gt;0.54.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TU injections produce a low incidence of POME with injections by experienced nurses, but recurrence is more frequent than by chance. Post-injection haematoma was not observed even among men using anticoagulant and\/or antiplatelet drugs, and polycythaemia was a minor problem rarely requiring treatment other than optimising inter-injection interval.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/eje-14-0891","type":"journal-article","created":{"date-parts":[[2015,1,31]],"date-time":"2015-01-31T02:00:42Z","timestamp":1422669642000},"page":"511-517","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":40,"title":["Complications of injectable testosterone undecanoate in routine clinical practice"],"prefix":"10.1093","volume":"172","author":[{"given":"T","family":"Middleton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Fennell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Savkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Jayadev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Conway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"Handelsman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"5","key":"1_24701611","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1210\/endo-21-5-649","volume":"21","author":"HAMILTON","year":"1937","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"key":"3_24188822","first-page":"380","volume":"13","year":"1957","journal-title":"Recent Progress in Hormone Research","ISSN":"https:\/\/id.crossref.org\/issn\/0079-9963","issn-type":"print"},{"issue":"2","key":"4_32167513","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1530\/acta.0.0790366","volume":"79","author":"Nieschlag","year":"1975","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"5","key":"5_17913992","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s00345-003-0372-x","volume":"21","author":"K\u00a0\u00a0hn","year":"2003","journal-title":"World journal of urology","ISSN":"https:\/\/id.crossref.org\/issn\/0724-4983","issn-type":"print"},{"issue":"6","key":"6_6283063","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/j.1939-4640.1998.tb02086.x","volume":"19","author":"Zhang","year":"1998","journal-title":"Journal of Andrology","ISSN":"https:\/\/id.crossref.org\/issn\/0196-3635","issn-type":"print"},{"issue":"3","key":"7_22525542","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/j.1365-2265.2006.02618.x","volume":"65","author":"Nieschlag","year":"2006","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"10","key":"8_42813302","doi-asserted-by":"publisher","first-page":"642","DOI":"10.5694\/mja11.11277","volume":"196","author":"Handelsman","year":"2012","journal-title":"Medical Journal of Australia","ISSN":"https:\/\/id.crossref.org\/issn\/1326-5377","issn-type":"print"},{"key":"9_48107337","doi-asserted-by":"crossref","first-page":"548","DOI":"10.5694\/mja13.10111","volume":"199","year":"2013","journal-title":"Medical Journal of Australia","ISSN":"https:\/\/id.crossref.org\/issn\/1326-5377","issn-type":"print"},{"key":"10_50058498","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1517\/14656566.2014.944896","volume":"15","year":"2014","journal-title":"Expert opinion on pharmacotherapy","ISSN":"https:\/\/id.crossref.org\/issn\/1465-6566","issn-type":"print"},{"issue":"6","key":"11_37377973","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1210\/jc.2009-2575","volume":"95","author":"Fernandez-Balsells","year":"2010","journal-title":"Journal of Clinical Endocrinology &amp; 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