{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:11:49Z","timestamp":1785773509761,"version":"3.56.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Context<\/jats:title><jats:p>Impairments of muscle function and strength in patients with primary hyperparathyroidism (PHPT) are rarely addressed, although decreased muscle function may contribute to increased fracture risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to assess the changes in muscle strength, muscle function, postural stability, quality of life (QoL), and well-being during treatment with vitamin D or placebo before and after parathyroidectomy (PTX) in PHPT patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A randomized placebo-controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>We included 46 PHPT patients, mean age 58 (range 29\u201377) years and 35 (76%) were women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Daily treatment with 70\u200a\u03bcg (2800\u200aIU) cholecalciferol or placebo for 52 weeks. Treatment was administered 26 weeks before PTX and continued for 26 weeks after PTX.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Changes in QoL and measures of muscle strength and function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Preoperatively, 25-hydroxyvitamin D (25OHD) increased significantly (50\u201394\u200anmol\/l) compared with placebo (57\u201352\u200anmol\/l). We did not measure any beneficial effects of supplementation with vitamin D compared with placebo regarding well-being, QoL, postural stability, muscle strength, or function. In all patients, we measured marked improvements in QoL, well-being (<jats:italic>P<\/jats:italic>&lt;0.01), muscle strength in the knee flexion and extension (<jats:italic>P<\/jats:italic>&lt;0.001), and muscle function tests (<jats:italic>P<\/jats:italic>&lt;0.01) after surgical cure. Postural stability improved during standing with eyes closed (<jats:italic>P<\/jats:italic>&lt;0.05), but decreased with eyes open (<jats:italic>P<\/jats:italic>&lt;0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with PHPT and 25OHD levels around 50\u200anmol\/l did not benefit from vitamin D supplementation concerning muscle strength, muscle function, postural stability, well-being, or QoL. Independent of preoperative 25OHD levels, PTX improved these parameters.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-14-0940","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T02:38:26Z","timestamp":1422931106000},"page":"609-617","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":24,"title":["No beneficial effects of vitamin D supplementation on muscle function or quality of life in primary hyperparathyroidism: results from a randomized controlled trial"],"prefix":"10.1093","volume":"172","author":[{"given":"Lars","family":"Rolighed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Rejnmark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Sikjaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Heickendorff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vestergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Mosekilde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peer","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"7261","key":"1_10464545","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1136\/bmj.321.7261.598","volume":"321","author":"Vestergaard","year":"2000","journal-title":"BMJ","ISSN":"https:\/\/id.crossref.org\/issn\/0959-8138","issn-type":"print"},{"key":"2_46329748","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S8756-3282(97)00078-1","volume":"21","year":"1997","ISSN":"https:\/\/id.crossref.org\/issn\/8756-3282","issn-type":"print"},{"key":"3_50069821","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00268-013-2273-5","volume":"38","year":"2014","journal-title":"World journal of surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0364-2313","issn-type":"print"},{"issue":"12","key":"4_44360165","doi-asserted-by":"publisher","first-page":"4366","DOI":"10.1210\/jc.2012-3720","volume":"97","author":"Gallagher","year":"2012","journal-title":"Journal of Clinical Endocrinology &amp; 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