{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:32:33Z","timestamp":1791304353428,"version":"4.3.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The saline infusion test (SIT) is widely used as a confirmatory test for primary aldosteronism (PA). SIT results are judged as follows: post-test aldosterone levels &lt;50\u200ang\/l exclude PA, whereas levels &gt;50\u200ang\/l confirm PA. We hypothesized that post-SIT aldosterone concentrations indicate the severity of PA and might predict outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The study includes 256 PA patients of the German Conn's Registry who prospectively underwent SIT. The data of 126 patients with complete follow-up of 1.2\u00b10.3 years after diagnosis were analyzed. The patients were divided into two groups with post-SIT aldosterone levels of 50\u2013100\u200ang\/l (group 1; <jats:italic>n<\/jats:italic>=38) and of &gt;100\u200ang\/l (group 2; <jats:italic>n<\/jats:italic>=88).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients in group 2 had a significantly shorter duration of hypertension (7.5 vs 11.7 years (median), <jats:italic>P<\/jats:italic>=0.014), higher systolic blood pressure (BP; 151\u00b116 vs 143\u00b117\u200ammHg, <jats:italic>P<\/jats:italic>=0.036), lower serum potassium (3.3\u00b10.6 vs 3.5\u00b10.4\u200ammol\/l, <jats:italic>P<\/jats:italic>=0.006), higher 24-h urine protein excretion (7.4 vs 5.4\u200amg\/dl (median), <jats:italic>P<\/jats:italic>=0.012), and were more often female (<jats:italic>P<\/jats:italic>=0.038). They showed more often unilateral disease (<jats:italic>P<\/jats:italic>&lt;0.005) with larger tumors (14\u00b110 vs 7\u00b110\u200amm, <jats:italic>P<\/jats:italic>=0.021), underwent more often adrenalectomy (75% vs 37%, <jats:italic>P<\/jats:italic>&lt;0.005), required a lower number of antihypertensive drugs after adrenalectomy (1.2\u00b11.2 vs 2.5\u00b11.4, <jats:italic>P<\/jats:italic>=0.001), had a faster normalization of urinary protein excretion (with medical treatment <jats:italic>P<\/jats:italic>=0.049; with Adx <jats:italic>P<\/jats:italic>&lt;0.005) at follow-up, and more frequently underlying well-characterized mutation (<jats:italic>P<\/jats:italic>=0.047).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PA patients with post-SIT aldosterone levels of &gt;100\u200ang\/l have a more rapid development of PA caused more frequently by unilateral disease with larger aldosterone-producing adenomas. However, this group of patients may have a significantly better outcome following specific treatment.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-14-1013","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T06:36:22Z","timestamp":1422513382000},"page":"443-450","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":27,"title":["Post-saline infusion test aldosterone levels indicate severity and outcome in primary aldosteronism"],"prefix":"10.1093","volume":"172","author":[{"given":"Marianne","family":"Weigel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Riester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Hanslik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger S","family":"Willenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Endres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Allolio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Beuschlein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Quinkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"1","key":"1_42351771","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1530\/EJE-11-1013","volume":"167","year":"2012","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"12","key":"2_46534171","doi-asserted-by":"publisher","first-page":"4826","DOI":"10.1210\/jc.2013-2805","volume":"98","year":"2013","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"3_45574117","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1161\/01.HYP.0000230444.01215.6a","volume":"48","year":"2006","journal-title":"OCL Hypertension"},{"issue":"4","key":"4_33857276","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1210\/jc.2008-2116","volume":"94","year":"2009","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"8","key":"5_18810532","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.jacc.2005.01.015","volume":"45","author":"Milliez","year":"2005","journal-title":"Journal of the American College of Cardiology","ISSN":"https:\/\/id.crossref.org\/issn\/0735-1097","issn-type":"print"},{"issue":"6","key":"6_36347499","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1055\/s-0029-1243257","volume":"42","author":"Quinkler","year":"2010","journal-title":"Hormone and metabolic research. 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