{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:40:58Z","timestamp":1792640458095,"version":"4.5.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The prevalence of type 2 diabetes is increased in polycystic ovary syndrome (PCOS), but the prevalence of other diseases is not clarified. We aimed to investigate morbidity and medicine prescriptions in PCOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A National Register-based study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with PCOS (PCOS Denmark and an embedded cohort; PCOS Odense University Hospital (OUH)) and one control population. Premenopausal women with PCOS underwent clinical and biochemical examination (PCOS OUH,<jats:italic>n<\/jats:italic>=1217). PCOS Denmark (<jats:italic>n<\/jats:italic>=19\u200a199) included women with PCOS in the Danish National Patient Register. Three age-matched controls were included per patient (<jats:italic>n<\/jats:italic>=57\u200a483).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Diagnosis codes and filled prescriptions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean (range) age of the PCOS Denmark group and controls was 30.6 (12\u201360) years. Patients in PCOS Denmark had higher Charlson index, higher prevalence of diabetes, dyslipidemia, and hypertension than controls. PCOS was associated with a two times increased risk of stroke and thrombosis, whereas the risk of other cardiovascular diseases was not increased. Thyroid disease, asthma, migraine, and depression were more prevalent in PCOS Denmark vs controls, whereas fractures were rarer. Infertility was increased in patients compared with controls, but the mean number of births was higher in PCOS. Medicine prescriptions within all diagnosis areas were significantly higher in PCOS patients than in controls.<\/jats:p><jats:p>In PCOS OUH, polycystic ovaries (PCO) and irregular menses were associated with a more adverse metabolic risk profile, but individual Rotterdam criteria were not associated with cardiometabolic diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cardiometabolic and psychiatric morbidity were significantly increased in a Danish population with PCOS. Medical diseases are frequent also in young patients with PCOS.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-14-1108","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T06:42:42Z","timestamp":1423204962000},"page":"627-638","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":139,"title":["Morbidity and medicine prescriptions in a nationwide Danish population of patients diagnosed with polycystic ovary syndrome"],"prefix":"10.1093","volume":"172","author":[{"given":"Dorte","family":"Glintborg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine","family":"Hass Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads","family":"Nybo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Abrahamsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"1","key":"1_17987236","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","volume":"81","year":"2004","journal-title":"Fertility and sterility","ISSN":"https:\/\/id.crossref.org\/issn\/0015-0282","issn-type":"print"},{"key":"2_50103617","first-page":"1","volume":"4","year":"2014","journal-title":"EUROPEAN JOURNAL ENDOCRINOLOGY"},{"key":"3_49628055","first-page":"281","volume":"4","year":"2010","journal-title":"Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0951-3590","issn-type":"print"},{"key":"4_50103618","first-page":"995","volume":"5","year":"2003","journal-title":"Obstetrics &amp; Gynecology","ISSN":"https:\/\/id.crossref.org\/issn\/0029-7844","issn-type":"print"},{"key":"5_50103619","first-page":"E628","volume":"4","year":"2013","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"6_48310499","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1210\/jc.2013-3399","volume":"99","year":"2014","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"7_45954519","first-page":"141","volume":"1","year":"1999","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"key":"8_49628056","first-page":"1570","volume":"6","year":"2004","journal-title":"Fertility and sterility","ISSN":"https:\/\/id.crossref.org\/issn\/0015-0282","issn-type":"print"},{"key":"9_50103620","first-page":"498","volume":"5","year":"2010","journal-title":"Diabetic medicine : a journal of the British Diabetic Association","ISSN":"https:\/\/id.crossref.org\/issn\/0742-3071","issn-type":"print"},{"key":"10_50103621","first-page":"581","volume":"7","year":"1998","journal-title":"Journal of clinical epidemiology","ISSN":"https:\/\/id.crossref.org\/issn\/0895-4356","issn-type":"print"},{"key":"11_50103622","first-page":"595","volume":"5","year":"2000","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"key":"12_50103623","first-page":"599","volume":"8","year":"1992","journal-title":"Acta obstetricia et gynecologica Scandinavica","ISSN":"https:\/\/id.crossref.org\/issn\/0001-6349","issn-type":"print"},{"key":"13_50103624","first-page":"926","volume":"6","year":"2013","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"key":"14_50103625","first-page":"2038","volume":"5","year":"2010","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"15_50103626","first-page":"2291","volume":"7","year":"2010","journal-title":"Fertility and sterility","ISSN":"https:\/\/id.crossref.org\/issn\/0015-0282","issn-type":"print"},{"key":"16_50103627","first-page":"17954e","volume":"3","year":"2014","journal-title":"INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM"},{"key":"17_50103628","first-page":"187","volume":"2","year":"2012","journal-title":"EXPERT REVIEW OF RESPIRATORY MEDICINE"},{"key":"18_50103629","first-page":"3339","volume":"12","year":"2011","journal-title":"Human Reproduction","ISSN":"https:\/\/id.crossref.org\/issn\/0268-1161","issn-type":"print"},{"key":"19_49628072","first-page":"15","volume":"1","year":"2008","journal-title":"Human Reproduction Update","ISSN":"https:\/\/id.crossref.org\/issn\/1355-4786","issn-type":"print"},{"key":"20_50103630","first-page":"884","volume":"80","year":"2013","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"key":"21_49628057","first-page":"453","volume":"2","year":"2004","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"22_49628054","first-page":"146","volume":"2","year":"2012","journal-title":"Human Reproduction Update","ISSN":"https:\/\/id.crossref.org\/issn\/1355-4786","issn-type":"print"},{"key":"23_42171500","first-page":"4237","volume":"11","year":"2006","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"24_26866903","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1210\/jcem-21-11-1440","volume":"21","year":"1961","journal-title":"JOURNAL OF CLINICAL ENDOCRINOLOGY"},{"key":"25_27454243","first-page":"385","volume":"4","year":"1985","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"key":"26_50103631","first-page":"4426","volume":"12","year":"2000","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"7_suppl","key":"27_40365995","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1177\/1403494811401482","volume":"39","author":"Lynge","year":"2011","journal-title":"Scandinavian Journal of Public Health","ISSN":"https:\/\/id.crossref.org\/issn\/1403-4948","issn-type":"print"},{"key":"28_50103632","first-page":"39","volume":"1","year":"2013","journal-title":"Fertility and sterility","ISSN":"https:\/\/id.crossref.org\/issn\/0015-0282","issn-type":"print"},{"key":"29_50103633","first-page":"1","volume":"4","year":"2013","journal-title":"ADOLESCENT HEALTH MEDICINE AND THERAPEUTICS"},{"key":"30_32003512","first-page":"373","volume":"5","year":"1987","journal-title":"Journal of chronic diseases","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9681","issn-type":"print"},{"key":"31_50103634","first-page":"1130","volume":"11","year":"2005","journal-title":"Medical care","ISSN":"https:\/\/id.crossref.org\/issn\/0025-7079","issn-type":"print"},{"key":"32_50103635","first-page":"3251","volume":"9","year":"2012","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"33_48541981","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000341838","volume":"40","year":"2013","journal-title":"Frontiers of hormone research","ISSN":"https:\/\/id.crossref.org\/issn\/0301-3073","issn-type":"print"},{"key":"34_50103636","first-page":"2369","volume":"9","year":"2012","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"key":"35_50103637","first-page":"732","volume":"6","year":"2010","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"key":"36_50103638","first-page":"115E","volume":"2","year":"2013","journal-title":"CMAJ CANADIAN MEDICAL ASSOCIATION JOURNAL"},{"key":"37_50103639","first-page":"E1319","volume":"18","year":"2011","journal-title":"CMAJ CANADIAN MEDICAL ASSOCIATION JOURNAL"},{"key":"38_49870576","first-page":"1","volume":"31","year":"2014","journal-title":"Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0951-3590","issn-type":"print"},{"key":"39_50103640","first-page":"e97041","volume":"5","year":"2014","ISSN":"https:\/\/id.crossref.org\/issn\/1932-6203","issn-type":"print"},{"key":"40_50103641","first-page":"385","volume":"4","year":"2012","journal-title":"Maturitas","ISSN":"https:\/\/id.crossref.org\/issn\/0378-5122","issn-type":"print"},{"key":"41_50103642","first-page":"217","volume":"2","year":"2013","journal-title":"CLINICAL AND EXPERIMENTAL OBSTETRICS GYNECOLOGY"},{"key":"42_50103643","first-page":"449","volume":"5","year":"2013","journal-title":"EXPERT REVIEW OF ENDOCRINOLOGY METABOLISM"},{"key":"43_50103644","first-page":"364","volume":"5","year":"2000","journal-title":"Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0951-3590","issn-type":"print"},{"key":"44_50103645","first-page":"779","volume":"3","year":"1992","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"45_50103646","first-page":"124","volume":"2","year":"2000","journal-title":"Diabetic medicine : a journal of the British Diabetic Association","ISSN":"https:\/\/id.crossref.org\/issn\/0742-3071","issn-type":"print"},{"key":"46_50103647","first-page":"683","volume":"6","year":"2005","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"key":"47_50103648","first-page":"1779","volume":"6","year":"2013","journal-title":"Fertility and sterility","ISSN":"https:\/\/id.crossref.org\/issn\/0015-0282","issn-type":"print"},{"key":"48_50103649","first-page":"207","volume":"2","year":"2012","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"key":"49_49953064","first-page":"1","volume":"6","year":"2013","journal-title":"CLINICAL EPIDEMIOLOGY"},{"key":"50_50103650","first-page":"2333","volume":"10","year":"2014","journal-title":"Human Reproduction","ISSN":"https:\/\/id.crossref.org\/issn\/0268-1161","issn-type":"print"},{"key":"51_43563282","first-page":"289","volume":"3","year":"2005","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"key":"52_50103651","first-page":"4565","volume":"12","year":"2013","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/172\/5\/627.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/172\/5\/627.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T14:42:12Z","timestamp":1691073732000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/172\/5\/627\/6660863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":52,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.1530\/eje-14-1108","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}