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Most recently, components of the complex have been associated with defects of other PKA subunits, such as the catalytic subunits PRKACA (adrenal hyperplasia) and PRKACB (pigmented spots, myxomas, pituitary adenomas). In this report, we review CNC, its clinical features, diagnosis, treatment and molecular etiology, including<jats:italic>PRKAR1A<\/jats:italic>mutations and the newest on<jats:italic>PRKACA<\/jats:italic>and<jats:italic>PRKACB<\/jats:italic>defects especially as they pertain to adrenal tumors and Cushing's syndrome.<\/jats:p>","DOI":"10.1530\/eje-15-0209","type":"journal-article","created":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T04:44:25Z","timestamp":1435725865000},"page":"M85-M97","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":352,"title":["Carney complex: an update"],"prefix":"10.1093","volume":"173","author":[{"given":"Ricardo","family":"Correa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevi","family":"Salpea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine A","family":"Stratakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"2015082718040542000_173.4.M85.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-7192(03)00006-4"},{"key":"2015082718040542000_173.4.M85.2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.9.4041"},{"key":"2015082718040542000_173.4.M85.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1980.tb07266.x"},{"key":"2015082718040542000_173.4.M85.4","doi-asserted-by":"crossref","unstructured":"Carney JA Gordon H Carpenter PC Shenoy BV Go VL . 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