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Therefore, we aimed to compare the prevalence of type 2 diabetes mellitus and metabolic syndrome (MetS) in newly diagnosed PA patients to a matched control cohort of the background population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 305 PA patients of the prospective German Conn's Registry were compared to the population-based Study of Health In Pomerania (SHIP1;<jats:italic>n<\/jats:italic>=2454). A 1:1 match regarding sex, age, and BMI resulted in 269 matched pairs regarding type 2 diabetes and 183 matched pairs regarding MetS. Of the total, 153 PA patients underwent oral glucose tolerance testing (OGTT) at diagnosis and 38 PA patients were reevaluated at follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Type 2 diabetes and MetS were significantly more frequent in PA patients than in the control population (17.2% vs 10.4%,<jats:italic>P<\/jats:italic>=0.03; 56.8% vs 44.8%,<jats:italic>P<\/jats:italic>=0.02 respectively). Also, HbA1c levels were higher in PA patients than in controls (<jats:italic>P<\/jats:italic>&lt;0.01). Of the total, 35.3% of non-diabetic PA patients showed an abnormal OGTT (\u00bc newly diagnosed type 2 diabetes and \u00be impaired glucose tolerance). PA patients with an abnormal OGTT at baseline presented with significantly improved 2\u200ah OGTT glucose (<jats:italic>P<\/jats:italic>=0.01) at follow-up. We detected a negative correlation between 2\u200ah OGTT glucose levels and serum potassium (<jats:italic>P<\/jats:italic>&lt;0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Type 2 diabetes and MetS are more prevalent in patients with PA than in controls matched for sex, age, BMI, and blood pressure. This may explain in part the increased cardiovascular disease morbidity and mortality in PA patients.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-15-0450","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T02:19:58Z","timestamp":1443665998000},"page":"665-675","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":135,"title":["Increased prevalence of diabetes mellitus and the metabolic syndrome in patients with primary aldosteronism of the German Conn's Registry"],"prefix":"10.1093","volume":"173","author":[{"given":"Gregor","family":"Hanslik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"Wallaschofski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Dietz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Riester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Allolio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Quack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars C","family":"Rump","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger S","family":"Willenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Beuschlein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Quinkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Hannemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"_","family":"_","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"2015093019191100000_173.5.665.1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1295438"},{"key":"2015093019191100000_173.5.665.2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2116"},{"key":"2015093019191100000_173.5.665.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.015"},{"key":"2015093019191100000_173.5.665.4","doi-asserted-by":"crossref","unstructured":"Brown NJ . 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