{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:06:06Z","timestamp":1773745566200,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Context<\/jats:title><jats:p>Patients in long-term remission of Cushing's syndrome (CS) commonly report impaired quality of life (QoL). The CushingQoL questionnaire is a disease-specific QoL questionnaire for patients diagnosed with CS. The developers of the CushingQoL recommend using a global (total) score to assess QoL. However, the global score does not capture all aspects of QoL as outlined by the World Health Organization (WHO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the study was to compare the performance of different scoring options to determine the optimal method for the CushingQoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and patients<\/jats:title><jats:p>Patients in remission from CS (<jats:italic>n<\/jats:italic>=341) were recruited from the Cushing's Syndrome Research Foundation's email listserv and Facebook page, and asked to complete the CushingQoL and a short demographics survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using an exploratory analysis, adequate model fit was obtained for the global score, as well as a 2-subscale (psychosocial issues and physical problems) scoring solution. Confirmatory methods were performed to identify the optimal scoring solution. Both the global score and the 2-subscale scoring solution showed adequate model fit. However, a <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> difference test indicated that the 2-subscale scoring solution was a significantly better fit than the global score (<jats:italic>P<\/jats:italic>&lt;0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>If doctors or researchers would like to tease apart physical and psychosocial issues, the 2-subscale scoring solution would be recommended, since this solution showed to be optimal in scoring the CushingQoL. Regardless of the scoring solution used, the CushingQoL has proven to be a valuable resource for assessing health-related QoL in patients with CS.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-15-0640","type":"journal-article","created":{"date-parts":[[2015,10,3]],"date-time":"2015-10-03T00:32:54Z","timestamp":1443832374000},"page":"33-40","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":19,"title":["Using subscales when scoring the Cushing's quality of life questionnaire"],"prefix":"10.1093","volume":"174","author":[{"given":"Jitske","family":"Tiemensma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Depaoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M","family":"Felt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"2016011113531379000_174.1.33.1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s12098-013-1203-8","article-title":"Cushing syndrome","volume":"81","author":"Bista","year":"2014","journal-title":"Indian Journal of Pediatrics"},{"key":"2016011113531379000_174.1.33.2","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0140-6736(14)61375-1","article-title":"Cushing's syndrome","volume":"386","author":"Lacroix","year":"2015","journal-title":"Lancet"},{"key":"2016011113531379000_174.1.33.3","first-page":"281","article-title":"Cushing's syndrome: epidemiology and developments in disease management","volume":"7","author":"Sharma","year":"2015","journal-title":"Clinical Epidemiology"},{"key":"2016011113531379000_174.1.33.4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0512"},{"key":"2016011113531379000_174.1.33.5","doi-asserted-by":"publisher","DOI":"10.1159\/000314317"},{"key":"2016011113531379000_174.1.33.6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2734"},{"key":"2016011113531379000_174.1.33.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.03082.x"},{"key":"2016011113531379000_174.1.33.8","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0534"},{"key":"2016011113531379000_174.1.33.9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11102-015-0640-y","article-title":"Quality of life in Cushing's syndrome","volume":"18","author":"Santos","year":"2015","journal-title":"Pituitary"},{"key":"2016011113531379000_174.1.33.10","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0762"},{"key":"2016011113531379000_174.1.33.11","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0307"},{"key":"2016011113531379000_174.1.33.12","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0272"},{"key":"2016011113531379000_174.1.33.13","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-1013"},{"key":"2016011113531379000_174.1.33.14","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/cen.12521","article-title":"Predictors of quality of life in 102 patients with treated Cushing's disease","volume":"82","author":"Carluccio","year":"2015","journal-title":"Clinical Endocrinology"},{"key":"2016011113531379000_174.1.33.15","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(95)00112-K"},{"key":"2016011113531379000_174.1.33.16","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0228"},{"key":"2016011113531379000_174.1.33.17","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1007\/s11136-013-0396-7","article-title":"Mapping CushingQOL scores to EQ-5D utility values using data from the European Registry on Cushing's syndrome (ERCUSYN)","volume":"22","author":"Badia","year":"2013","journal-title":"Quality of Life Research"},{"key":"2016011113531379000_174.1.33.18","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0325"},{"key":"2016011113531379000_174.1.33.19","doi-asserted-by":"publisher","DOI":"10.1007\/s40271-013-0010-7"},{"key":"2016011113531379000_174.1.33.20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s40271-013-0012-5","article-title":"Psychometric evaluation of the Cushing's quality-of-life questionnaire","volume":"6","author":"Nelson","year":"2013","journal-title":"Patient"},{"key":"2016011113531379000_174.1.33.21","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1524-4733.2008.00470.x","article-title":"Recommendations on evidence needed to support measurement equivalence between electronic and paper-based patient-reported outcome (PRO) measures: ISPOR ePRO Good Research Practices Task Force report","volume":"12","author":"Coons","year":"2009","journal-title":"Value in Health"},{"key":"2016011113531379000_174.1.33.22","unstructured":"Furr R Bacharach V . 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