{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T02:48:01Z","timestamp":1785206881414,"version":"3.55.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Context<\/jats:title><jats:p>The role of <jats:sup>18<\/jats:sup>F-labeled 2-fluoro-2-deoxy-<jats:sc>d<\/jats:sc>-glucose (FDG) positron emission tomography (PET)\/computed tomography (CT) in the post-operative monitoring of patients with adrenocortical carcinoma (ACC) is still unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the accuracy of FDG PET\/CT to diagnose ACC recurrence in a real world setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and methods<\/jats:title><jats:p>Retrospective evaluation of data of 57 patients with presumed ACC recurrence at CT scan who underwent FDG PET\/CT within a median time of 20 days. We compared the results of either FDG PET\/CT or CT with a gold standard confirmation of recurrence (positive histopathology report of removed\/biopsied lesions or radiological progression of target lesions at follow-up) to assess their diagnostic performance at different body sites to correctly categorize target lesions. We also assessed whether FDG PET\/CT findings may be useful to inform the management strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 48 patients with confirmed ACC recurrence, we found that FDG PET\/CT had lower sensitivity than CT in diagnosing liver and lung recurrences of ACC. FDG PET\/CT had higher specificity than CT in categorizing liver lesions. FDG PET\/CT had a greater positive likelihood ratio than CT to identify liver and abdominal ACC recurrences. The management strategy was changed based on FDG PET\/CT findings in 12 patients (21.1%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The greater sensitivity of CT may be partly expected due the specific inclusion criteria of the study; however, the greater specificity of FDG PET\/CT was particularly useful in ruling out suspected ACC recurrences found by CT. Thus, use of FDG PET\/CT as a second-line test in the post-operative surveillance of ACC patients following CT finding of a potential recurrence may have a significant impact on patient management.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-15-0707","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T02:09:07Z","timestamp":1441678147000},"page":"749-756","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":19,"title":["18F-FDG PET\/CT in the post-operative monitoring of patients with adrenocortical carcinoma"],"prefix":"10.1093","volume":"173","author":[{"given":"A","family":"Ardito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Massaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Pelosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Zaggia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Basile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Brambilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Vigna-Taglianti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Duregon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Arena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Perotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Penna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Terzolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"2015102318231814000_173.6.749.1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2312021185"},{"key":"2015102318231814000_173.6.749.2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.273055031"},{"key":"2015102318231814000_173.6.749.3","doi-asserted-by":"publisher","DOI":"10.1148\/rg.266065057"},{"key":"2015102318231814000_173.6.749.4","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2383042164"},{"key":"2015102318231814000_173.6.749.5","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.08.1431"},{"key":"2015102318231814000_173.6.749.6","doi-asserted-by":"crossref","unstructured":"Dong A Cui Y Wang Y Zuo C Bai Y . 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