{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:15:40Z","timestamp":1785161740986,"version":"3.55.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to explore whether circulating testosterone (T) concentration is associated with the occurrence and risk for acute coronary syndromes (ACS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This case\u2013control study included male patients with acute myocardial infarction (AMI) (<jats:italic>n<\/jats:italic>=174) or unstable angina pectoris (UAP) (<jats:italic>n<\/jats:italic>=90) and healthy controls (<jats:italic>n<\/jats:italic>=238). Patients gave serum samples during the acute (<jats:italic>n<\/jats:italic>=264) and recovery (<jats:italic>n<\/jats:italic>=132) phases after a median of 10.5 months after the incident event. Secondary events (ACS or cardiovascular death) were registered during the following 6 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the acute phase, AMI and UAP patients had similar significantly reduced concentrations of serum testosterone in comparison to controls. Testosterone associated inversely with weight, the degree of inflammation (i.e. C-reactive protein concentration) and signs of a chronic infection. In a multiadjusted Cox regression, when compared to testosterone concentrations considered high-normal (14.91\u201334.0\u200anmol\/l), low-normal testosterone (9.26\u201314.90\u200anmol\/l) in the acute phase predicted better prognosis for cardiovascular death rate with a hazard ratio (HR) of 0.17 (0.04\u20130.68, <jats:italic>P<\/jats:italic>=0.012). The increased testosterone concentrations after the recovery period did not associate with future cardiovascular disease events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low-normal testosterone levels in the acute phase of ACS predicted better survival. The observation may indicate better adaptation to stress in survivors and warrants further study.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-15-0757","type":"journal-article","created":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T17:23:19Z","timestamp":1452964999000},"page":"481-489","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":11,"title":["Adaptation to acute coronary syndrome-induced stress with lowering of testosterone: a possible survival 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