{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:50:13Z","timestamp":1783486213118,"version":"3.55.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the incidence of congenital hypothyroidism (CH) with delayed TSH elevation among low-birth-weight (LBW) newborns in North-Eastern Italy and to verify if they need a second or third screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Analysis of clinical and biochemical data of newborns affected by CH with delayed TSH elevation identified by neonatal screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of all newborns with birth weight (BW) &lt;2500\u2009g and evidence of delayed TSH elevation at newborn screening were collected between 2011 and 2014. Confirmatory tests were based on serum TSH and FT<jats:sub>4<\/jats:sub>levels. All their clinical signs at diagnosis were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>57.5% of LBW newborns with delayed TSH increase at neonatal screening presented a CH with delayed TSH elevation and began a treatment with<jats:sc>l<\/jats:sc>-thyroxine. The incidence of this condition in North-Eastern Italy is therefore 1:908. The remaining infants presented a subclinical hypothyroidism (21.25%) or a complete normal serum thyroid function (21.25%). These data could be drawn only from a retesting strategy of neonatal screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our report describes the incidence of CH with delayed TSH rise in North-Eastern Italy and differentiates this clinical condition from other thyroid dysfunctions of preterm or LBW newborns. The second-screening strategy for CH in neonates with BW\u2009&lt;\u20092500\u2009g proved useful in detecting newborns who otherwise would not be identified at the first screening.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-15-1233","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T02:39:35Z","timestamp":1470883175000},"page":"395-402","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":45,"title":["Congenital hypothyroidism with delayed TSH elevation in low-birth-weight infants: incidence, diagnosis and management"],"prefix":"10.1093","volume":"175","author":[{"given":"Paolo","family":"Cavarzere","sequence":"first","affiliation":[{"name":"Pediatric ClinicDepartment of Mother and Child, University Hospital of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Camilot","sequence":"additional","affiliation":[{"name":"Pediatric ClinicDepartment of Mother and Child, University Hospital of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florina Ion","family":"Popa","sequence":"additional","affiliation":[{"name":"Pediatric ClinicDepartment of Mother and Child, University Hospital of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Lauriola","sequence":"additional","affiliation":[{"name":"Pediatric ClinicDepartment of Mother and Child, University Hospital of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Teofoli","sequence":"additional","affiliation":[{"name":"Pediatric ClinicDepartment of Mother and Child, University Hospital of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Gaudino","sequence":"additional","affiliation":[{"name":"Pediatric ClinicDepartment of Mother and Child, University Hospital of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Vincenzi","sequence":"additional","affiliation":[{"name":"Pediatric ClinicDepartment of Mother and Child, University Hospital of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Antoniazzi","sequence":"additional","affiliation":[{"name":"Pediatric ClinicDepartment of Mother and Child, University Hospital of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"2016092517180934000_175.5.395.1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1136\/fn.87.3.F165","article-title":"Neonatal thyroid disorders","volume":"87","author":"Ogilvy-Stuart","year":"2002","journal-title":"Archives of Disease in Childhood. 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