{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:09:05Z","timestamp":1793506145532,"version":"4.5.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Non-pharmacological interventions are important in reducing risk for osteoporotic fractures. We investigated the effects of a 16-week individualized resistance training intervention on bone mineral density (BMD), bone turnover markers and 10-year relative risk (RR) for osteoporotic fracture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Interventional study with a follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 37 elderly women (mean age 71.9 \u00b1 3.1 years) with decreased muscle strength participated in the resistance training intervention three times per week with 60 min per session for 16 weeks under the supervision of a licensed physiotherapist. Total hip BMD with quantitative CT, bone markers (sclerostin, osteocalcin, CTX, PINP, IGF-1, 25(OH)-D) and 10-year RR for osteoporotic fracture were measured at baseline, post-intervention and at 1-year follow-up after the end of the intervention. Eleven age- and sex-matched controls did not participate in the intervention but were studied at baseline and at 1-year follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Resistance training seemed to increase total hip BMD by 6% (<jats:italic>P<\/jats:italic>= 0.005). Sclerostin (<jats:italic>P<\/jats:italic>&lt; 0.001) and total osteocalcin (<jats:italic>P<\/jats:italic>= 0.04) increased while other bone markers remained unchanged. A 10-year RR for major osteoporotic and hip fracture remained unchanged. At follow-up total hip BMD (<jats:italic>P<\/jats:italic>&lt; 0.001) decreased back to the baseline level with a simultaneous decrease in serum sclerostin (<jats:italic>P<\/jats:italic>= 0.045), CTX (<jats:italic>P<\/jats:italic>&lt; 0.001) and an increase in 25(OH)-D (<jats:italic>P<\/jats:italic>&lt; 0.001), 10-year RR for major osteoporotic (<jats:italic>P<\/jats:italic>= 0.002) and hip fracture (<jats:italic>P<\/jats:italic>= 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest an important role of continuous supervised resistance training for the prevention of osteoporotic fractures in elderly women with decreased muscle strength.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-16-0521","type":"journal-article","created":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T03:43:15Z","timestamp":1473997395000},"page":"571-582","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":38,"title":["Bone mineral density is increased after a 16-week resistance training intervention in elderly women with decreased muscle strength"],"prefix":"10.1093","volume":"175","author":[{"given":"Ville","family":"Huovinen","sequence":"first","affiliation":[{"name":"1Turku PET CentreUniversity of Turku, Turku, Finland"},{"name":"2Department of RadiologyUniversity of Turku and Turku University Hospital, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaisa K","family":"Ivaska","sequence":"additional","affiliation":[{"name":"3Department of Cell Biology and AnatomyInstitute of Biomedicine, University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riku","family":"Kiviranta","sequence":"additional","affiliation":[{"name":"4Department of EndocrinologyTurku University Hospital, Turku, Finland"},{"name":"5Departments of Medicine and Medical Biochemistry and GeneticsUniversity of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bucci","sequence":"additional","affiliation":[{"name":"1Turku PET CentreUniversity of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heta","family":"Lipponen","sequence":"additional","affiliation":[{"name":"1Turku PET CentreUniversity of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Sandboge","sequence":"additional","affiliation":[{"name":"6Folkh\u00e4lsan Research CentreHelsinki, Finland"},{"name":"7Department of Chronic Disease PreventionNational Institute for Health and Welfare, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juho","family":"Raiko","sequence":"additional","affiliation":[{"name":"1Turku PET CentreUniversity of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan G","family":"Eriksson","sequence":"additional","affiliation":[{"name":"6Folkh\u00e4lsan Research CentreHelsinki, Finland"},{"name":"7Department of Chronic Disease PreventionNational Institute for Health and Welfare, Helsinki, Finland"},{"name":"8Department of General Practice and Primary Health CareUniversity of Helsinki and Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riitta","family":"Parkkola","sequence":"additional","affiliation":[{"name":"1Turku PET CentreUniversity of Turku, Turku, Finland"},{"name":"2Department of RadiologyUniversity of Turku and Turku University Hospital, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Iozzo","sequence":"additional","affiliation":[{"name":"1Turku PET CentreUniversity of Turku, Turku, Finland"},{"name":"9Institute of Clinical PhysiologyNational Research Council (CNR), Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirjo","family":"Nuutila","sequence":"additional","affiliation":[{"name":"1Turku PET CentreUniversity of Turku, Turku, Finland"},{"name":"4Department of EndocrinologyTurku University Hospital, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"2016101919334288000_175.6.571.1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-012-2074-y"},{"key":"2016101919334288000_175.6.571.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102013440503"},{"key":"2016101919334288000_175.6.571.3","doi-asserted-by":"publisher","DOI":"10.1177\/0898264309332839"},{"key":"2016101919334288000_175.6.571.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-005-1938-9"},{"key":"2016101919334288000_175.6.571.5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03520240037038"},{"key":"2016101919334288000_175.6.571.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1999.tb05201.x"},{"key":"2016101919334288000_175.6.571.7","unstructured":"Liu CJ Latham NK. 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