{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T18:12:17Z","timestamp":1778782337232,"version":"3.51.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Patients with <jats:italic>SDHx<\/jats:italic> mutations need long-term radiological surveillance for the development of paragangliomas and phaeochromocytomas, but no longitudinal data exist. The aim of the study was to assess the performance of rapid-sequence non-contrast magnetic resonance imaging (MRI) in the long-term monitoring of patients with <jats:italic>SDHx<\/jats:italic> mutations.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Retrospective study between 2005 and 2015 at a University Hospital and regional endocrine genetics referral centre. Clinical and imaging data of 47 patients with <jats:italic>SDHx<\/jats:italic> mutations (<jats:italic>SDHB<\/jats:italic> (36), <jats:italic>SDHC<\/jats:italic> (6) and <jats:italic>SDHD<\/jats:italic> (5)) who had surveillance for detection of paragangliomas by rapid-sequence non-contrast MRI (base of skull to pubic symphysis) were collected.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Twelve index cases (nine <jats:italic>SDHB<\/jats:italic>, one <jats:italic>SDHC<\/jats:italic> and two <jats:italic>SDHD<\/jats:italic>) and 35 mutation-positive relatives were monitored for a mean of 6.4 years (range 3.1\u201310.0 years). Mean age at the end of the study: <jats:italic>SDHB<\/jats:italic> 46.9 \u00b1 17.6 years; <jats:italic>SDHC<\/jats:italic> 42.3 \u00b1 24.4 years; <jats:italic>SDHD<\/jats:italic> 54.9 \u00b1 10.6 years. On excluding imaging at initial diagnosis of index cases, 42 patients underwent 116 rapid-sequence MRI scans: 83 scans were negative and 31 scans were positive for sPGL\/HNPGL in 13 patients. Most patients had multiple scans (<jats:italic>n<\/jats:italic> = number of patients (number of rapid-sequence MRI scans during screening)): <jats:italic>n<\/jats:italic> = 9 (2), <jats:italic>n<\/jats:italic> = 20 (3), <jats:italic>n<\/jats:italic> = 6 (4), <jats:italic>n<\/jats:italic> = 1 (6). Nine patients (three index) were diagnosed with new paragangliomas during surveillance and non-operated tumour size was monitored in nine patients. There were two false-positive scans (1.6%). Scans were repeated every 27 \u00b1 9 months.<\/jats:p>\n<\/jats:sec>\n<jats:sec><jats:title>Conclusions<\/jats:title>\n<jats:p>Biannual rapid-sequence non-contrast MRI is effective to monitor patients with <jats:italic>SDHx<\/jats:italic> mutations for detection of new tumours and monitoring of known tumours.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-16-0595","type":"journal-article","created":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T03:43:15Z","timestamp":1473997395000},"page":"561-570","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":33,"title":["Rapid-sequence MRI for long-term surveillance for paraganglioma and phaeochromocytoma in patients with succinate dehydrogenase mutations"],"prefix":"10.1093","volume":"175","author":[{"given":"Eleni","family":"Daniel","sequence":"first","affiliation":[{"name":"1Academic Unit of DiabetesEndocrinology and Reproduction, Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK"},{"name":"2Department of Endocrinology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Jones","sequence":"additional","affiliation":[{"name":"1Academic Unit of DiabetesEndocrinology and Reproduction, Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK"},{"name":"2Department of Endocrinology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Bull","sequence":"additional","affiliation":[{"name":"3Department of RadiologySheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Newell-Price","sequence":"additional","affiliation":[{"name":"1Academic Unit of DiabetesEndocrinology and Reproduction, Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK"},{"name":"2Department of Endocrinology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"2016101919334289000_175.6.561.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020152"},{"key":"2016101919334289000_175.6.561.2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.3.178"},{"key":"2016101919334289000_175.6.561.3","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5454.848"},{"key":"2016101919334289000_175.6.561.4","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-6-39"},{"key":"2016101919334289000_175.6.561.5","unstructured":"DeLellis RA. 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