{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:19:50Z","timestamp":1791235190160,"version":"4.1.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the effects of acyl ghrelin (AG) and desacyl ghrelin (DAG) on blood pressure (BP), heart rate (HR) and other autonomic parameters in healthy humans and to elucidate the hormonal mechanisms through which AG could exert its cardiovascular effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Seventeen healthy participants underwent frequent monitoring of systolic (sBP) and diastolic blood pressure (dBP), HR, respiratory rate (RR) and body surface temperature (Temp) during continuous infusion of AG, DAG, combined AG\u2009+\u2009DAG or saline control before and during an IV glucose tolerance test on 4 separate days. Plasma catecholamines, renin and aldosterone levels were also measured. Differences in outcome measures between treatment groups were assessed using mixed-model analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the saline control, AG and combined AG\u2009+\u2009DAG infusions decreased sBP, dBP, mean arterial blood pressure (MAP), HR and Temp. In contrast, DAG infusion did not alter BP, RR or Temp, but did decrease HR. The AG and AG\u2009+\u2009DAG infusions also raised plasma aldosterone levels compared to saline (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) without affecting renin or catecholamine levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The decrease in BP, HR, RR and Temp with AG infusion suggests mediation through the autonomic nervous system. The lack of response to DAG suggests that these autonomic effects require activation of the ghrelin receptor.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-16-0789","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T13:24:41Z","timestamp":1478784281000},"page":"123-132","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":26,"title":["Acute administration of acyl, but not desacyl ghrelin, decreases blood pressure in healthy humans"],"prefix":"10.1093","volume":"176","author":[{"given":"Cecilia J","family":"Zhang","sequence":"first","affiliation":[{"name":"2Division of EndocrinologyMetabolism and Nutrition, Department of Medicine, Duke University, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bidlingmaier","sequence":"additional","affiliation":[{"name":"3Medizinische Klinik und Poliklinik IVLudwig-Maximilians-Universit\u00e4t, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mekibib","family":"Altaye","sequence":"additional","affiliation":[{"name":"4BiostatisticsClinical Translational Research Center, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C","family":"Page","sequence":"additional","affiliation":[{"name":"5Division of Pediatric Endocrinology and DiabetesDepartment of Pediatrics, Duke University, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"D\u2019Alessio","sequence":"additional","affiliation":[{"name":"1Division of EndocrinologyDiabetes and Metabolism, Department of Medicine, University of Cincinnati, Cincinnati, Ohio, USA"},{"name":"2Division of EndocrinologyMetabolism and Nutrition, Department of Medicine, Duke University, Durham, North Carolina, USA"},{"name":"6Cincinnati Veterans Affairs Medical CenterCincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias H","family":"Tsch\u00f6p","sequence":"additional","affiliation":[{"name":"1Division of EndocrinologyDiabetes and Metabolism, Department of Medicine, University of Cincinnati, Cincinnati, Ohio, USA"},{"name":"7Institute for Obesity and DiabetesHelmholtz Diabetes Center Munich and Division of Metabolic Diseases, Technical University, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Tong","sequence":"additional","affiliation":[{"name":"1Division of EndocrinologyDiabetes and Metabolism, Department of Medicine, University of Cincinnati, Cincinnati, Ohio, USA"},{"name":"2Division of EndocrinologyMetabolism and Nutrition, Department of Medicine, Duke University, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"2016120218051918000_176.2.123.1","doi-asserted-by":"publisher","DOI":"10.1038\/45230"},{"key":"2016120218051918000_176.2.123.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2015.03.005"},{"key":"2016120218051918000_176.2.123.3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2235"},{"key":"2016120218051918000_176.2.123.4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00582.2003"},{"key":"2016120218051918000_176.2.123.5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035708"},{"key":"2016120218051918000_176.2.123.6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604148"},{"key":"2016120218051918000_176.2.123.7","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0504"},{"key":"2016120218051918000_176.2.123.8","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1210\/jc.2015-4154","article-title":"Ghrelin impairs prandial glucose tolerance and insulin secretion in healthy humans despite increasing GLP-1","volume":"101","author":"Tong","year":"2016","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2016120218051918000_176.2.123.9","doi-asserted-by":"publisher","DOI":"10.1126\/science.1196154"},{"key":"2016120218051918000_176.2.123.10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00219.2007"},{"key":"2016120218051918000_176.2.123.11","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1598"},{"key":"2016120218051918000_176.2.123.12","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0982"},{"key":"2016120218051918000_176.2.123.13","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/dom.12675","article-title":"Abribat T & van der Lely AJ. 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