{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:41:51Z","timestamp":1791423711664,"version":"4.3.3"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effect of age at growth hormone (GH) treatment start on near adult height (NAH) in children with isolated GH deficiency (GHD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>NordiNet\u00ae International Outcome Study (IOS) (Nbib960128), a non-interventional, multicentre study, evaluates the long-term effectiveness and safety of Norditropin\u00ae (somatropin) (Novo Nordisk A\/S) in the real-life clinical setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients (<jats:italic>n<\/jats:italic>\u2009=\u2009172) treated to NAH (height at \u226518 years, or height velocity &lt;2\u2009cm\/year at \u226516 (boys) or \u226515 (girls) years) were grouped by age (years) at treatment start (early (girls, &lt;8; boys, &lt;9), intermediate (girls, 8\u201310; boys, 9\u201311) or late (girls, &gt;10; boys, &gt;11)) and GHD severity (&lt;3\u2009ng\/mL or 3 to \u226410\u2009ng\/mL). Multiple regression analysis was used to evaluate the effect of age at treatment start (as a categorical and continuous variable) on NAH standard deviation score (SDS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Age at treatment start had a marked effect on NAH SDS; NAH SDS achieved by patients starting treatment early (<jats:italic>n<\/jats:italic>\u2009=\u200940 (boys, 70.0%); least squares mean (standard error) \u22120.76 (0.14)) exceeded that achieved by those starting later (intermediate,<jats:italic>n<\/jats:italic>\u2009=\u200942 (boys, 57.1%); \u22121.14 (0.15); late,<jats:italic>n<\/jats:italic>\u2009=\u200990 (boys, 68.9%); \u22121.21 (0.10)). Multiple regression analysis showed a significant association between NAH SDS and age at treatment start (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0242), baseline height SDS (HSDS) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), target HSDS (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), and GHD severity (<jats:italic>P<\/jats:italic>\u2009=\u20090.0012). Most (78.5%) patients achieved a normal NAH irrespective of age at treatment start.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early initiation of GH treatment in children with isolated GHD improves their chance of achieving their genetic height potential.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-16-1024","type":"journal-article","created":{"date-parts":[[2017,8,6]],"date-time":"2017-08-06T00:10:18Z","timestamp":1501978218000},"page":"421-429","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":65,"title":["Early growth hormone treatment start in childhood growth hormone deficiency improves near adult height: analysis from NordiNet\u00ae International Outcome Study"],"prefix":"10.1093","volume":"177","author":[{"given":"Michel","family":"Polak","sequence":"first","affiliation":[{"name":"1Endocrinologie Gyn\u00e9cologie Diab\u00e9tologie P\u00e9diatriques, H\u00f4pital Universitaire Necker Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris Universit\u00e9 Paris Descartes, INSERM U1016, Institut IMAGINE, Centre de R\u00e9f\u00e9rence des Maladies Endocriniennes Rares de la Croissance, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Blair","sequence":"additional","affiliation":[{"name":"2Department of Endocrinology, Alder Hey Children\u2019s NHS Foundation Trust, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Primoz","family":"Kotnik","sequence":"additional","affiliation":[{"name":"3Department of Pediatric Endocrinology, University Children\u2019s Hospital, University Medical Center Ljubljana, and Medical Faculty, University of Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Effie","family":"Pournara","sequence":"additional","affiliation":[{"name":"4Global Medical Affairs, Novo Nordisk Health Care AG, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte T\u00f8nnes","family":"Pedersen","sequence":"additional","affiliation":[{"name":"5Epidemiology, Novo Nordisk A\/S, S\u00f8borg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilman R","family":"Rohrer","sequence":"additional","affiliation":[{"name":"6Department of Pediatric Endocrinology, University Children\u2019s Hospital, Saarland University Medical Center, Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"ref321","first-page":"1532","article-title":"Diagnostic controversy: the diagnosis of childhood growth hormone deficiency revisited.","volume":"80","year":"1995","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/bmj.325.7355.70","article-title":"Adult height after long term treatment with recombinant growth hormone for idiopathic isolated growth hormone deficiency: observational follow up study of the French population based registry","volume":"325","year":"2002","journal-title":"BMJ"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/bmj.325.7355.70","article-title":"Adult height after long term treatment with recombinant growth hormone for idiopathic isolated growth hormone deficiency: observational follow up study of the French population based registry","volume":"325","year":"2002","journal-title":"BMJ"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1210\/jc.2005-2284","article-title":"Effect of growth hormone (GH) treatment on the near-final height of 1258 patients with idiopathic GH deficiency: analysis of a large international database.","volume":"91","year":"2006","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1687-9856-2015-1","article-title":"Increased height standard deviation scores in response to growth hormone therapy to near-adult height in older children with delayed skeletal maturation: results from the ANSWER Program","volume":"2015","year":"2015","journal-title":"International Journal of Pediatric Endocrinology"},{"key":"ref111","first-page":"528","article-title":"RogolADClarkPARoemmichJN and pubertal development in children and adolescents : effects of diet and physical activity","journal-title":"Growth American Journal of Clinical Nutrition"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1210\/jcem.84.4.5634","article-title":"Derivation and validation of a mathematical model for predicting the response to exogenous recombinant human growth hormone (GH) in prepubertal children with idiopathic GH deficiency. 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