{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T10:18:42Z","timestamp":1793182722623,"version":"4.5.0"},"reference-count":108,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>Tall stature is defined as a height of more than 2 standard deviations (<jats:sc>s.d.<\/jats:sc>) above average for same sex and age. Tall individuals are usually referred to endocrinologists so that hormonal disorders leading to abnormal growth are excluded. However, the majority of these patients have familial tall stature or constitutional advance of growth (generally associated with obesity), both of which are diagnoses of exclusion. It is necessary to have familiarity with a large number of rarer overgrowth syndromes, especially because some of them may have severe complications such as aortic aneurysm, thromboembolism and tumor predisposition and demand-specific follow-up approaches. Additionally, endocrine disorders associated with tall stature have specific treatments and for this reason their recognition is mandatory. With this review, we intend to provide an up-to-date summary of the genetic conditions associated with overgrowth to emphasize a practical diagnostic approach of patients with tall stature and to discuss the limitations of current growth interruption treatment options.<\/jats:p>","DOI":"10.1530\/eje-16-1054","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T01:45:22Z","timestamp":1489023922000},"page":"R339-R353","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":53,"title":["MANAGEMENT OF ENDOCRINE DISEASE: Diagnostic and therapeutic approach of tall stature"],"prefix":"10.1093","volume":"176","author":[{"given":"Edoarda V A","family":"Albuquerque","sequence":"first","affiliation":[{"name":"1Unidade de Endocrinologia Gen\u00e9ticaLaborat\u00f3rio de Endocrinologia Celular e Molecular (LIM\/25), Disciplina de Endocrinologia da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata C","family":"Scalco","sequence":"additional","affiliation":[{"name":"2Unidade de Endocrinologia do DesenvolvimentoLaborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular (LIM\/42) do Hospital das Clinicas, Disciplina de Endocrinologia da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"3Disciplina de Endocrinologia da Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o PauloS\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander A L","family":"Jorge","sequence":"additional","affiliation":[{"name":"1Unidade de Endocrinologia Gen\u00e9ticaLaborat\u00f3rio de Endocrinologia Celular e Molecular (LIM\/25), Disciplina de Endocrinologia da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"2017041317200928000_176.6.R339.1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000317440","article-title":"Auxology: an update","volume":"74","author":"Hermanussen","year":"2010","journal-title":"Hormone Research in Paediatrics"},{"key":"2017041317200928000_176.6.R339.2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/jn\/137.1.153","article-title":"Evaluation of the feasibility of international growth standards for school-aged children and adolescents","volume":"137","author":"Butte","year":"2007","journal-title":"Journal of Nutrition"},{"key":"2017041317200928000_176.6.R339.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-013-1271-x"},{"key":"2017041317200928000_176.6.R339.4","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nrendo.2015.165","article-title":"Short and tall stature: a new paradigm emerges","volume":"11","author":"Baron","year":"2015","journal-title":"Nature Reviews Endocrinology"},{"key":"2017041317200928000_176.6.R339.5","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jpeds.2016.02.068","article-title":"The Biology of Stature","volume":"173","author":"Jee","year":"2016","journal-title":"Journal of Pediatrics"},{"key":"2017041317200928000_176.6.R339.6","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/ajmg.a.36836","article-title":"PIK3CA-related overgrowth spectrum (PROS): diagnostic and testing eligibility criteria, differential diagnosis, and evaluation","volume":"167A","author":"Keppler-Noreuil","year":"2015","journal-title":"American Journal of Medical Genetics"},{"key":"2017041317200928000_176.6.R339.7","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1651-2227.1984.tb09966.x","article-title":"The pattern of growth in children with constitutional tall stature from birth to age 9 years. 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