{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:22:11Z","timestamp":1787170931137,"version":"build-2736575974"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,8]]},"abstract":"\n Objective<\/jats:title>\n To describe real-life dosing patterns in children with growth hormone deficiency (GHD), born small for gestational age (SGA) or with Turner syndrome (TS) receiving growth hormone (GH) and enrolled in the NordiNet International Outcome Study (IOS; Nbib960128) between 2006 and 2016.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n \n This non-interventional, multicentre study included paediatric patients diagnosed with GHD (isolated (IGHD) or multiple pituitary hormone deficiency (MPHD)), born SGA or with TS and treated according to everyday clinical practice from the Czech Republic (IGHD\/MPHD\/SGA\/TS:\n n<\/jats:italic>\n \u2009=\u2009425\/61\/316\/119), France (\n n<\/jats:italic>\n \u2009=\u20091404\/188\/970\/206), Germany (\n n<\/jats:italic>\n \u2009=\u20092603\/351\/1387\/411) and the UK (\n n<\/jats:italic>\n \u2009=\u2009259\/60\/87\/35).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n GH dosing was compared descriptively across countries and indications. Proportions of patients by GH dose group (low\/medium\/high) or GH dose change (decrease\/increase\/no change) during years 1 and 2 were also evaluated across countries and indications.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In the Czech Republic, GH dosing was generally within recommended levels. In France, average GH doses were higher for patients with IGHD, MPHD and SGA than in other countries. GH doses in TS tended to be at the lower end of the recommended label range, especially in Germany and the UK; the majority of patients were in the low-dose group. A significant inverse association between baseline height standard deviation score and GH dose was shown (\n P<\/jats:italic>\n \u2009<\u20090.05); shorter patients received higher doses. Changes in GH dose, particularly increases, were more common in the second (40%) than in the first year (25%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n GH dosing varies considerably across countries and indications. In particular, almost half of girls with TS received GH doses below practice guidelines and label recommendations.<\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/eje-16-1055","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T20:50:20Z","timestamp":1495140620000},"page":"145-155","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":17,"title":["Real-life GH dosing patterns in children with GHD, TS or born SGA: a report from the NordiNet\u00ae International Outcome Study"],"prefix":"10.1093","volume":"177","author":[{"given":"Oliver","family":"Blankenstein","sequence":"first","affiliation":[{"name":"1Center for Chronic Sick Children, Institute for Experimental Paediatric Endocrinology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Snajderova","sequence":"additional","affiliation":[{"name":"22nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Blair","sequence":"additional","affiliation":[{"name":"3Alder Hey Children\u2019s NHS Foundation Trust, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Effie","family":"Pournara","sequence":"additional","affiliation":[{"name":"4Novo Nordisk Health Care AG, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte T\u00f8nnes","family":"Pedersen","sequence":"additional","affiliation":[{"name":"5Epidemiology, Novo Nordisk A\/S, S\u00f8borg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle Oliver","family":"Petit","sequence":"additional","affiliation":[{"name":"6Department of Paediatric Endocrinology, H\u00f4pital des Enfants, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"ref111","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1373\/clinchem.2010.150631","article-title":"Consensus statement on the standardization and evaluation of growth hormone and insulin-like growth factor assays","volume":"57","year":"2011","journal-title":"Clinical Chemistry"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"e0157277","DOI":"10.1371\/journal.pone.0157277","article-title":"Short stature: comparison of WHO and national growth standards\/references for height","volume":"11","year":"2016","journal-title":"PLoS ONE"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s40618-015-0418-0","article-title":"Efficacy and safety of growth hormone treatment in children with short stature: the Italian cohort of the GeNeSIS clinical study","volume":"39","year":"2016","journal-title":"Journal of Endocrinological 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