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Endocrine function undergoes major changes during aging, as well. Specifically, alterations in hormonal networks and concomitant hormonal deficits\/excess, augmented by poor sensitivity of tissues to their action, take place. As hypothalamic\u2013pituitary unit is the central regulator of crucial body functions, these alterations can be translated in significant clinical sequelae that can impair the quality of life and promote frailty and disease. Delineating the hormonal signaling alterations that occur across lifespan and exploring possible remedial interventions could possibly help us improve the quality of life of the elderly and promote longevity.<\/jats:p>","DOI":"10.1530\/eje-16-1061","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T01:35:15Z","timestamp":1488850515000},"page":"R283-R308","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":79,"title":["MECHANISMS IN ENDOCRINOLOGY: Aging and anti-aging: a Combo-Endocrinology overview"],"prefix":"10.1093","volume":"176","author":[{"given":"Evanthia","family":"Diamanti-Kandarakis","sequence":"first","affiliation":[{"name":"1Department of EndocrinologyDiabetes and Metabolic Diseases, Euroclinic Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Dattilo","sequence":"additional","affiliation":[{"name":"2ParthenogenLugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djuro","family":"Macut","sequence":"additional","affiliation":[{"name":"3Clinic for EndocrinologyDiabetes and Metabolic Diseases, Faculty of Medicine, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonidas","family":"Duntas","sequence":"additional","affiliation":[{"name":"4Medical SchoolUniversity of Ulm, Ulm, Germany"},{"name":"5Endocrine ClinicEvgenidion Hospital, University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstathios S","family":"Gonos","sequence":"additional","affiliation":[{"name":"6National Hellenic Research FoundationInstitute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios G","family":"Goulis","sequence":"additional","affiliation":[{"name":"7First Department of Obstetrics & GynecologyMedical School, Aristotle University of Thessaloniki, Unit of Reproductive Endocrinology, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina Kanaka","family":"Gantenbein","sequence":"additional","affiliation":[{"name":"8First Department of Pediatrics Medical SchoolAghia Sophia Children\u2019s Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Kapetanou","sequence":"additional","affiliation":[{"name":"6National Hellenic Research FoundationInstitute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eftychia","family":"Koukkou","sequence":"additional","affiliation":[{"name":"9Endocrine DepartmentElena Venizelou Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Lambrinoudaki","sequence":"additional","affiliation":[{"name":"102nd Department of Obstetrics and GynecologyUniversity of Athens, Aretaieio Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Michalaki","sequence":"additional","affiliation":[{"name":"11Endocrine DivisionInternal Medicine Department, University Hospital of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahla","family":"Eftekhari-Nader","sequence":"additional","affiliation":[{"name":"12Department of Internal MedicineMc Goven Medical School, The University of Texas, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Pasquali","sequence":"additional","affiliation":[{"name":"13S. 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