{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:52:03Z","timestamp":1772164323573,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>New European guidelines for the management of adrenal incidentalomas were recently released. One of the most novel recommendations is to stop following patients when they present a typical, small and non-secreting adenoma. We report here the case of a 71-year-old man with such an adenoma, who developed an adrenocortical carcinoma (ACC) fourteen years later, with subsequent metastases and death. Clinically, he had a normal blood pressure and no sign of hormonal hypersecretion. The hormonal work-up showed no hormone excess: urinary free cortisol level was normal, the diurnal cortisol rhythm was respected and urinary catecholamine metabolites levels were normal. Computed tomography (CT) scan showed a homogeneous lesion, with a low density. The lesion remained unchanged during the five years of follow-up. Eight years after the last CT, a large right heterogeneous adrenal mass was incidentally discovered during an ultrasound examination. On CT scan, it was a 6\u2009cm heterogeneous tumor. On hormonal work-up, there was no secretion. The patient was operated of an adrenalectomy, and the histology described an ACC with a Weiss score at 8, with no benign contingent. To our knowledge, this is the first case of an ACC occurring in a patient with prior adrenal imaging showing a typical benign adenoma.<\/jats:p>","DOI":"10.1530\/eje-17-0037","type":"journal-article","created":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:41:26Z","timestamp":1490661686000},"page":"K15-K19","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":20,"title":["From benign adrenal incidentaloma to adrenocortical carcinoma: an exceptional random event"],"prefix":"10.1093","volume":"176","author":[{"given":"I","family":"Belmihoub","sequence":"first","affiliation":[{"name":"1Department of EndocrinologyCenter for Rare Adrenal Diseases, H\u00f4pital Cochin, Assistance Publique H\u00f4pitaux de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Silvera","sequence":"additional","affiliation":[{"name":"2Department of RadiologySaint Joseph Hospital, Paris, 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France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Bertherat","sequence":"additional","affiliation":[{"name":"1Department of EndocrinologyCenter for Rare Adrenal Diseases, H\u00f4pital Cochin, Assistance Publique H\u00f4pitaux de Paris, Paris, France"},{"name":"6Institut CochinInstitut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1016, Centre National de la Recherche Scientifique UMR8104, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Assi\u00e9","sequence":"additional","affiliation":[{"name":"1Department of EndocrinologyCenter for Rare Adrenal Diseases, H\u00f4pital Cochin, Assistance Publique H\u00f4pitaux de Paris, Paris, France"},{"name":"6Institut CochinInstitut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1016, Centre National de la Recherche Scientifique UMR8104, Universit\u00e9 Paris Descartes, Sorbonne Paris 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