{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:50:37Z","timestamp":1791298237194,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Studies investigating long-term health conditions in patients with craniopharyngioma are limited by short follow-up durations and generally do not compare long-term health effects according to initial craniopharyngioma treatment approach. In addition, studies comparing long-term health conditions between patients with childhood- and adult-onset craniopharyngioma report conflicting results. The objective of this study was to analyse a full spectrum of long-term health effects in patients with craniopharyngioma according to initial treatment approach and age group at craniopharyngioma presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross-sectional study based on retrospective data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We studied a single-centre cohort of 128 patients with craniopharyngioma treated from 1980 onwards (63 patients with childhood-onset disease). Median follow-up since craniopharyngioma presentation was 13 years (interquartile range: 5\u201323 years). Initial craniopharyngioma treatment approaches included gross total resection (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925), subtotal resection without radiotherapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200944), subtotal resection with radiotherapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925), cyst aspiration without radiotherapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098), and\n                      <jats:sup>90<\/jats:sup>\n                      Yttrium brachytherapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pituitary hormone deficiencies (98%), visual disturbances (75%) and obesity (56%) were the most common long-term health conditions observed. Different initial craniopharyngioma treatment approaches resulted in similar long-term health effects. Patients with childhood-onset craniopharyngioma experienced significantly more growth hormone deficiency, diabetes insipidus, panhypopituitarism, morbid obesity, epilepsy and psychiatric conditions compared with patients with adult-onset disease. Recurrence-\/progression-free survival was significantly lower after initial craniopharyngioma treatment with cyst aspiration compared with other therapeutic approaches. Survival was similar between patients with childhood- and adult-onset craniopharyngioma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Long-term health conditions were comparable after different initial craniopharyngioma treatment approaches and were generally more frequent in patients with childhood- compared with adult-onset disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/eje-17-0044","type":"journal-article","created":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T20:40:31Z","timestamp":1490128831000},"page":"755-767","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":114,"title":["Very long-term sequelae of craniopharyngioma"],"prefix":"10.1093","volume":"176","author":[{"given":"Mark","family":"Wijnen","sequence":"first","affiliation":[{"name":"1Section EndocrinologyDepartment of Medicine, Pituitary Centre Rotterdam, Erasmus University Medical Centre, Rotterdam, the Netherlands"},{"name":"2Department of Paediatric Oncology\/HaematologyErasmus MC \u2013 Sophia Children\u2019s Hospital, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marry M","family":"van den Heuvel-Eibrink","sequence":"additional","affiliation":[{"name":"2Department of Paediatric Oncology\/HaematologyErasmus MC \u2013 Sophia Children\u2019s Hospital, Rotterdam, the Netherlands"},{"name":"3Princess Maxima Centre for Paediatric OncologyUtrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A M J L","family":"Janssen","sequence":"additional","affiliation":[{"name":"1Section EndocrinologyDepartment of Medicine, Pituitary Centre Rotterdam, Erasmus University Medical Centre, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coriene 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