{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T05:28:43Z","timestamp":1705728523314},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,9]]},"abstract":"Context<\/jats:title>Regular monitoring of serum IGF-I levels during growth hormone (GH) therapy has been recommended, for assessing treatment compliance and safety.<\/jats:p><\/jats:sec>Objective<\/jats:title>To investigate serum IGF-I SDS levels during GH treatment in children with GH deficiency, and to identify potential determinants of these levels.<\/jats:p><\/jats:sec>Design, patients and methods<\/jats:title>This observational cohort study included all patients (n<\/jats:italic>\u2009=\u2009308) with childhood-onset non-acquired or acquired GH deficiency (GHD) included in the database of a single academic pediatric care center over a period of 10 years for whom at least one serum IGF-I SDS determination during GH treatment was available. These determinations had to have been carried out centrally, with the same immunoradiometric assay. Serum IGF-I SDS levels were determined as a function of sex, age and pubertal stage, according to our published normative data.<\/jats:p><\/jats:sec>Results<\/jats:title>Over a median of 4.0 (2\u20135.8) years of GH treatment per patient, 995 serum IGF-I SDS determinations were recorded. In addition to BMI SDS, height SDS and GH dose (P<\/jats:italic>\u2009<\u20090.01), etiological group (P<\/jats:italic>\u2009<\u20090.01) had a significant effect on serum IGF-I SDS levels, with patients suffering from acquired GHD having higher serum IGF-I SDS levels than those with non-acquired GHD, whereas sex, age, pubertal stage, treatment duration, hormonal status (isolated GHD (IGHD) vs multiple pituitary hormone deficiency (MPHD)) and initial severity of GHD, had no effect.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>These original findings have important clinical implications for long-term management and highlight the need for careful and appropriate monitoring of serum IGF-I SDS and GH dose, particularly in patients with acquired GHD, to prevent the unnecessary impact of potential comorbid conditions.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-17-0215","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:50:15Z","timestamp":1501548615000},"page":"267-276","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":3,"title":["Impact of the underlying etiology of growth hormone deficiency on serum IGF-I SDS levels during GH treatment in children"],"prefix":"10.1093","volume":"177","author":[{"given":"Juliane","family":"L\u00e9ger","sequence":"first","affiliation":[{"name":"1Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Universitaire Robert Debr\u00e9, Service d\u2019Endocrinologie Diab\u00e9tologie P\u00e9diatrique, Centre de R\u00e9f\u00e9rence des Maladies Endocriniennes Rares de la Croissance et du d\u00e9veloppement, Paris, France"},{"name":"2Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"3Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (Inserm), Unit\u00e9 1141, DHU Protect, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damir","family":"Mohamed","sequence":"additional","affiliation":[{"name":"4Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Universitaire Robert Debr\u00e9, Unit of Clinical Epidemiology, Paris, France"},{"name":"5Inserm, CIC-EC 1426, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Dos Santos","sequence":"additional","affiliation":[{"name":"1Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Universitaire Robert Debr\u00e9, Service d\u2019Endocrinologie Diab\u00e9tologie P\u00e9diatrique, Centre de R\u00e9f\u00e9rence des Maladies Endocriniennes Rares de la Croissance et du d\u00e9veloppement, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Ben Azoun","sequence":"additional","affiliation":[{"name":"1Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Universitaire Robert Debr\u00e9, Service d\u2019Endocrinologie Diab\u00e9tologie P\u00e9diatrique, Centre de R\u00e9f\u00e9rence des Maladies Endocriniennes Rares de la Croissance et du d\u00e9veloppement, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Z\u00e9naty","sequence":"additional","affiliation":[{"name":"1Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Universitaire Robert Debr\u00e9, Service d\u2019Endocrinologie Diab\u00e9tologie P\u00e9diatrique, Centre de R\u00e9f\u00e9rence des Maladies Endocriniennes Rares de la Croissance et du d\u00e9veloppement, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Simon","sequence":"additional","affiliation":[{"name":"1Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Universitaire Robert Debr\u00e9, Service d\u2019Endocrinologie Diab\u00e9tologie P\u00e9diatrique, Centre de R\u00e9f\u00e9rence des Maladies Endocriniennes Rares de la Croissance et du d\u00e9veloppement, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Paulsen","sequence":"additional","affiliation":[{"name":"1Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Universitaire Robert Debr\u00e9, Service d\u2019Endocrinologie Diab\u00e9tologie P\u00e9diatrique, Centre de R\u00e9f\u00e9rence des Maladies Endocriniennes Rares de la Croissance et du d\u00e9veloppement, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laetitia","family":"Martinerie","sequence":"additional","affiliation":[{"name":"1Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Universitaire Robert Debr\u00e9, Service d\u2019Endocrinologie Diab\u00e9tologie P\u00e9diatrique, Centre de R\u00e9f\u00e9rence des Maladies Endocriniennes Rares de la Croissance et du d\u00e9veloppement, Paris, France"},{"name":"2Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"3Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (Inserm), Unit\u00e9 1141, DHU Protect, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Chevenne","sequence":"additional","affiliation":[{"name":"6Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Universitaire Robert Debr\u00e9, Service de Biochimie-Hormonologie, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne","family":"Alberti","sequence":"additional","affiliation":[{"name":"2Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"4Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Universitaire Robert Debr\u00e9, Unit of Clinical Epidemiology, Paris, France"},{"name":"5Inserm, CIC-EC 1426, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"Carel","sequence":"additional","affiliation":[{"name":"1Assistance 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Research"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000087692","article-title":"IGF-I and IGF binding protein-3 levels during initial GH dosage step-up are indicators of GH sensitivity in GH-deficient children and short children born small for gestational age","volume":"64","year":"2005","journal-title":"Hormone Research"},{"key":"ref201","first-page":"13","article-title":"Body Mass Index variations: centiles from birth to 87 years","volume":"45","year":"1991","journal-title":"European Journal of Clinical Nutrition"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1210\/jc.2007-0204","article-title":"Insulin growth factor-based dosing of growth hormone therapy in children: a randomized, controlled study","volume":"92","year":"2007","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000350251","article-title":"Understanding the 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Drug and Therapeutics Committee","volume":"143","year":"2003","journal-title":"Journal of Pediatrics"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2147\/VHRM.S2881","article-title":"Detection of metabolic syndrome features among childhood cancer survivors: a target to prevent disease","volume":"4","year":"2008","journal-title":"Vascular Health and Risk Management"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1159\/000452150","article-title":"Guidelines for growth hormone and insulin-like growth Factor-I treatment in children and adolescents: growth hormone deficiency, idiopathic short stature, and primary insulin-like growth factor-I deficiency","volume":"86","year":"2016","journal-title":"Hormone Research in Paediatrics"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1530\/EJE-11-0560","article-title":"Effects of oral and transdermal estrogen on IGF1, IGFBP3, IGFBP1, serum lipids, and glucose in 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Research"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4158\/EP.14.2.143","article-title":"Compliance and persistence in pediatric and adult patients receiving growth hormone therapy","volume":"14","year":"2008","journal-title":"Endocrine Practice"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1046\/j.1365-2265.2000.01105.x","article-title":"Monitoring serum insulin-like growth factor-I (IGF-I), IGF binding protein-3 (IGFBP-3), IGF-I\/IGFBP-3 molar ratio and leptin during growth hormone treatment for disordered growth","volume":"53","year":"2000","journal-title":"Clinical Endocrinology"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1210\/jcem.87.1.8150","article-title":"Effects of dose and gender on the growth and growth factor response to GH in GH-deficient children: implications for efficacy and safety","volume":"87","year":"2002","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1067\/mpd.2002.127662","article-title":"Is insulin-like growth factor-1 monitoring useful in assessing the response to growth hormone of growth hormone-deficient children?","volume":"141","year":"2002","journal-title":"Journal of Pediatrics"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"240","DOI":"10.4274\/jcrpe.v1i5.240","article-title":"Combined evaluation of IGF-1 and IGFBP-3 as an index of efficacy and safety in growth hormone treated patients","volume":"1","year":"2009","journal-title":"Journal of Clinical Research in Pediatric Endocrinology"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.clinthera.2008.02.017","article-title":"Observations of nonadherence to recombinant human growth hormone therapy in clinical practice","volume":"30","year":"2008","journal-title":"Clinical Therapeutics"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrc1387","article-title":". Insulin-like growth factors and neoplasia","volume":"4","year":"2004","journal-title":"Nature Reviews Cancer"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12902-015-0080-8","article-title":"Growth hormone (GH) dose-dependent IGF-I response relates to pubertal height gain","volume":"15","year":"2015","journal-title":"BMC Endocrine Disorders"},{"key":"ref231","first-page":"550","article-title":"Growth hormone (GH)-deficient men are more responsive to GH replacement therapy than women","volume":"82","year":"1997","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1210\/jc.2007-1003","article-title":"Subnormal serum insulin-like growth factor-I levels in young adults with childhood-onset nonacquired growth hormone (GH) deficiency who recover normal GH secretion may indicate less severe but persistent pituitary failure","volume":"92","year":"2007","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1373\/clinchem.2011.169466","article-title":"Serum concentrations of insulin-like growth factor (IGF)-1 and IGF binding protein-3 (IGFBP-3), IGF-1\/IGFBP-3 ratio, and markers of bone turnover: reference values for French children and adolescents and z-score comparability with other references","volume":"57","year":"2011","journal-title":"Clinical Chemistry"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000351800","article-title":"Growth hormone treatment adherence in prepubertal and pubertal children with different growth disorders","volume":"80","year":"2013","journal-title":"Hormone Research in Paediatrics"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/BF02018614","article-title":"Height of normal pituitary gland as a function of age evaluated by magnetic resonance imaging in children","volume":"21","year":"1991","journal-title":"Pediatric Radiology"},{"key":"ref191","volume-title":"Auxologie, M\u00e9thodes et S\u00e9quences","year":"1970"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/177\/3\/EJE-17-0215.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1530\/EJE-17-0215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:10:43Z","timestamp":1676391043000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/177\/3\/267\/6655221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":33,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/eje-17-0215","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9]]}}}