{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:08:49Z","timestamp":1791454129396,"version":"4.3.3"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Prolonged hypocalcemia but normal intact parathyroid hormone (iPTH) levels after surgery for primary hyperparathyroidism (PHPT) are referred to as \u2018hungry bone syndrome\u2019 (HBS). The aim was to evaluate preoperative risk factors for HBS with a focus on the impact of 25-hydroxyvitamin D (25(OH)D) deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Patients having undergone initial successful surgery for sporadic PHPT within 6 years were considered for retrospective analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 385 patients were evaluated, of whom 33 (8.6%) developed HBS influencing negatively the postoperative bone metabolism. All patients underwent biochemical evaluations two days before parathyroid surgery and were followed biochemically on a daily basis in the first postoperative week and thereafter at 8 weeks and 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>No relationship was established between preoperative 25(OH)D deficiency and HBS. The only significant risk factor for HBS in multivariable analysis was high levels of preoperative iPTH. As HBS therefore cannot be predicted preoperatively, we recommend a consistent postoperative calcium and vitamin D supplementation to improve the bone metabolism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/eje-17-0416","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T23:14:01Z","timestamp":1504739641000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":35,"title":["The impact of vitamin D status on hungry bone syndrome after surgery for primary hyperparathyroidism"],"prefix":"10.1093","volume":"178","author":[{"given":"Reto Martin","family":"Kaderli","sequence":"first","affiliation":[{"name":"1Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria"},{"name":"2Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Riss","sequence":"additional","affiliation":[{"name":"1Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Dunkler","sequence":"additional","affiliation":[{"name":"3Section for Clinical Biometrics, Centre of Medical Statistics, Informatics and Intelligent Systems (CeMSIIS), Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Pietschmann","sequence":"additional","affiliation":[{"name":"4Department of Pathophysiology and Allergy Research, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Selberherr","sequence":"additional","affiliation":[{"name":"1Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Scheuba","sequence":"additional","affiliation":[{"name":"1Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Niederle","sequence":"additional","affiliation":[{"name":"1Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"ref351","volume-title":"The Parathyroids: Basic and Clinical Concepts","year":"2015"},{"key":"ref651","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1136\/bmj.3.5876.391","article-title":"Symptomatic hypomagnesaemia after parathyroidectomy","volume":"3","year":"1973","journal-title":"BMJ"},{"key":"ref51","first-page":"45","article-title":"ThielSRomijnJAHamdyNA Hungry bone syndrome : still a challenge in the post - operative management of primary hyperparathyroidism : a systematic review of the literature of https org","author":"WitteveenJEvan","journal-title":"European Journal Endocrinology"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1177\/000313480206801211","article-title":"Are preoperative serum calcium, parathyroid hormone, and adenoma weight predictive of postoperative hypocalcemia?","volume":"68","year":"2002","journal-title":"American Surgeon"},{"key":"ref601","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00774-005-0680-x","article-title":"Bisphosphonate pretreatment attenuates hungry bone syndrome postoperatively in subjects with primary hyperparathyroidism","volume":"24","year":"2006","journal-title":"Journal of Bone and Mineral Metabolism"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0300-2977(98)00010-2","article-title":"Consequences of long-term hyperparathyroidism","volume":"53","year":"1998","journal-title":"Netherlands Journal of Medicine"},{"key":"ref541","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1136\/bmj.1.6161.450","article-title":"Value of 1-alpha-hydroxy vitamin D3 in treatment of primary hyperparathyroidism before parathyroidectomy","volume":"1","year":"1979","journal-title":"BMJ"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/BF02067385","article-title":"Primary hyperparathyroidism in Austria: results of an 8-year prospective study","volume":"16","year":"1992","journal-title":"World Journal of Surgery"},{"key":"ref391","first-page":"45","article-title":"ThielSRomijnJAHamdyNA Hungry bone syndrome : still a challenge in the post - operative management of primary hyperparathyroidism : a systematic review of the literature of https org","author":"WitteveenJEvan","journal-title":"European Journal Endocrinology"},{"key":"ref671","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1055\/s-0032-1308998","article-title":"Bone metabolism in patients with primary hyperparathyroidism before and after surgery","volume":"44","year":"2012","journal-title":"Hormone and Metabolic Research"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0002-9610(86)90436-8","article-title":"Adenoma weight: a predictor of transient hypocalcemia after parathyroidectomy","volume":"152","year":"1986","journal-title":"American Journal of Surgery"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.surg.2005.09.018","article-title":"25-Hydroxyvitamin D deficiency is a risk factor for symptoms of postoperative hypocalcemia and secondary hyperparathyroidism after minimally invasive parathyroidectomy","volume":"138","year":"2005","journal-title":"Surgery"},{"key":"ref501","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1210\/jc.2014-1413","article-title":"Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth International Workshop","volume":"99","year":"2014","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1007\/s00268-009-0377-8","article-title":"Vitamin D3 deficiency is associated with late-onset hypocalcemia after minimally invasive parathyroidectomy in a vitamin D borderline area.","volume":"34","year":"2010","journal-title":"World Journal of Surgery"},{"key":"ref621","first-page":"1","article-title":"Could we predict adenoma weight and postoperative serum calcium level with preoperative serum biochemical markers in patients with primary hyperparathyroidism?","volume":"16","year":"2007","journal-title":"Internet Journal of Surgery"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1001\/archsurg.135.2.142","article-title":"Risk factors for postoperative hypocalcemia after surgery for primary hyperparathyroidism","volume":"135","year":"2000","journal-title":"Archives of Surgery"},{"key":"ref551","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/BF03346273","article-title":"The effect of vitamin D status on the severity of bone disease and on the other features of primary hyperparathyroidism (pHPT) in a vitamin D deficient region","volume":"27","year":"2004","journal-title":"Journal of Endocrinological Investigation"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.surg.2007.05.004","article-title":"A \u2018defined baseline\u2019 in PTH monitoring increases surgical success in patients with multiple gland disease","volume":"142","year":"2007","journal-title":"Surgery"},{"key":"ref631","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.remn.2009.10.003","article-title":"Scintigraphic findings in hungry bone syndrome following parathyroidectomy","volume":"29","year":"2010","journal-title":"Revista Espa\u00f1ola de Medicina Nuclear"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/0002-9343(88)90100-3","article-title":"Hungry bone syndrome: clinical and biochemical predictors of its occurrence after parathyroid surgery","volume":"84","year":"1988","journal-title":"American Journal of Medicine"},{"key":"ref481","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.surg.2007.09.026","article-title":"Impact of 25-hydroxyvitamin D deficiency on perioperative parathyroid hormone kinetics and results in patients with primary hyperparathyroidism","volume":"142","year":"2007","journal-title":"Surgery"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2265.1981.tb02749.x","article-title":"Parathyroid function after parathyroidectomy: evaluation by measurement of urinary cAMP","volume":"15","year":"1981","journal-title":"Clinical Endocrinology"},{"key":"ref381","first-page":"153","article-title":"Postoperative course of serum parathyroid hormone and calcium after surgery for primary hyperparathyroidism","volume":"55","year":"2001","journal-title":"Acta Oto-Rhino-Laryngologica Belgica"},{"key":"ref611","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1177\/000313480407000204","article-title":"Post-parathyroidectomy hypocalcemia: incidence, risk factors, and management","volume":"70","year":"2004","journal-title":"American Surgeon"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1210\/jc.2014-1413","article-title":"Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth International Workshop","volume":"99","year":"2014","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref41","first-page":"153","article-title":"Postoperative course of serum parathyroid hormone and calcium after surgery for primary hyperparathyroidism","volume":"55","year":"2001","journal-title":"Acta Oto-Rhino-Laryngologica Belgica"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.surg.2007.05.004","article-title":"A \u2018defined baseline\u2019 in PTH monitoring increases surgical success in patients with multiple gland disease","volume":"142","year":"2007","journal-title":"Surgery"},{"key":"ref411","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0002-9610(86)90436-8","article-title":"Adenoma weight: a predictor of transient hypocalcemia after parathyroidectomy","volume":"152","year":"1986","journal-title":"American Journal of Surgery"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1177\/000313480206801211","article-title":"Are preoperative serum calcium, parathyroid hormone, and adenoma weight predictive of postoperative hypocalcemia?","volume":"68","year":"2002","journal-title":"American Surgeon"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1136\/bmj.3.5876.391","article-title":"Symptomatic hypomagnesaemia after parathyroidectomy","volume":"3","year":"1973","journal-title":"BMJ"},{"key":"ref471","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1210\/jc.2013-3978","article-title":"Vitamin D treatment in primary hyperparathyroidism: a randomized placebo controlled trial","volume":"99","year":"2014","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref641","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/ki.2009.522","article-title":"Testosterone increases urinary calcium excretion and inhibits expression of renal calcium transport proteins","volume":"77","year":"2010","journal-title":"Kidney International"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"611","DOI":"10.7150\/ijms.4861","article-title":"Pre-operative serum alkaline phosphatase as a predictor for hypocalcemia post-parathyroid adenectomy","volume":"9","year":"2012","journal-title":"International Journal of Medical Sciences"},{"key":"ref521","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1067\/msy.2002.128484","article-title":"Recovery pattern of patients with osteitis fibrosa cystica in primary hyperparathyroidism after successful parathyroidectomy","volume":"132","year":"2002","journal-title":"Surgery"},{"key":"ref571","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2265.1981.tb02749.x","article-title":"Parathyroid function after parathyroidectomy: evaluation by measurement of urinary cAMP","volume":"15","year":"1981","journal-title":"Clinical Endocrinology"},{"key":"ref531","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0300-2977(98)00010-2","article-title":"Consequences of long-term hyperparathyroidism","volume":"53","year":"1998","journal-title":"Netherlands Journal of Medicine"},{"key":"ref581","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1001\/archsurg.135.2.142","article-title":"Risk factors for postoperative hypocalcemia after surgery for primary hyperparathyroidism","volume":"135","year":"2000","journal-title":"Archives of Surgery"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.remn.2009.10.003","article-title":"Scintigraphic findings in hungry bone syndrome following parathyroidectomy","volume":"29","year":"2010","journal-title":"Revista Espa\u00f1ola de Medicina Nuclear"},{"key":"ref561","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.surg.2011.09.018","article-title":"The effect of vitamin D levels on postoperative calcium requirements, symptomatic hypocalcemia, and parathormone levels following parathyroidectomy for primary hyperparathyroidism","volume":"150","year":"2011","journal-title":"Surgery"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1001\/jamasurg.2016.2310","article-title":"The American association of endocrine surgeons guidelines for definitive management of primary hyperparathyroidism","volume":"151","year":"2016","journal-title":"JAMA Surgery"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.surg.2011.09.018","article-title":"The effect of vitamin D levels on postoperative calcium requirements, symptomatic hypocalcemia, and parathormone levels following parathyroidectomy for primary hyperparathyroidism","volume":"150","year":"2011","journal-title":"Surgery"},{"key":"ref171","first-page":"394","article-title":"Primary hyperparathyroidism in Saudi Arabia: a review of 46 cases","volume":"62","year":"2007","journal-title":"Medical Journal of Malaysia"},{"key":"ref661","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1210\/jc.2016-1099","article-title":"Association of hypoalbuminemia with osteoporosis: analysis of the national health and nutrition examination survey","volume":"101","year":"2016","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref31","first-page":"305","article-title":"Daily follow-up of serum parathyroid hormone and calcium after surgery for primary hyperparathyroidism","volume":"28","year":"1999","journal-title":"Journal of Otolaryngology"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1067\/msy.2002.128484","article-title":"Recovery pattern of patients with osteitis fibrosa cystica in primary hyperparathyroidism after successful parathyroidectomy","volume":"132","year":"2002","journal-title":"Surgery"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1136\/bmj.1.6161.450","article-title":"Value of 1-alpha-hydroxy vitamin D3 in treatment of primary hyperparathyroidism before parathyroidectomy","volume":"1","year":"1979","journal-title":"BMJ"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/BF02067385","article-title":"Primary hyperparathyroidism in Austria: results of an 8-year prospective study","volume":"16","year":"1992","journal-title":"World Journal of Surgery"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00774-005-0680-x","article-title":"Bisphosphonate pretreatment attenuates hungry bone syndrome postoperatively in subjects with primary hyperparathyroidism","volume":"24","year":"2006","journal-title":"Journal of Bone and Mineral Metabolism"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1210\/jc.2013-3978","article-title":"Vitamin D treatment in primary hyperparathyroidism: a randomized placebo controlled trial","volume":"99","year":"2014","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref511","first-page":"394","article-title":"Primary hyperparathyroidism in Saudi Arabia: a review of 46 cases","volume":"62","year":"2007","journal-title":"Medical Journal of Malaysia"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/jn\/135.2.317","article-title":"Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D","volume":"135","year":"2005","journal-title":"Journal of Nutrition"},{"key":"ref441","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/0002-9343(88)90100-3","article-title":"Hungry bone syndrome: clinical and biochemical predictors of its occurrence after parathyroid surgery","volume":"84","year":"1988","journal-title":"American Journal of Medicine"},{"key":"ref431","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/jn\/135.2.317","article-title":"Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D","volume":"135","year":"2005","journal-title":"Journal of Nutrition"},{"key":"ref11","volume-title":"The Parathyroids: Basic and Clinical Concepts","year":"2015"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1055\/s-0032-1308998","article-title":"Bone metabolism in patients with primary hyperparathyroidism before and after surgery","volume":"44","year":"2012","journal-title":"Hormone and Metabolic Research"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1007\/s00268-012-1432-4","article-title":"Preoperative serum osteocalcin may predict postoperative elevated parathyroid hormone in patients with primary hyperparathyroidism","volume":"36","year":"2012","journal-title":"World Journal of Surgery"},{"key":"ref371","first-page":"305","article-title":"Daily follow-up of serum parathyroid hormone and calcium after surgery for primary hyperparathyroidism","volume":"28","year":"1999","journal-title":"Journal of Otolaryngology"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.surg.2007.09.026","article-title":"Impact of 25-hydroxyvitamin D deficiency on perioperative parathyroid hormone kinetics and results in patients with primary hyperparathyroidism","volume":"142","year":"2007","journal-title":"Surgery"},{"key":"ref401","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1007\/s00268-012-1432-4","article-title":"Preoperative serum osteocalcin may predict postoperative elevated parathyroid hormone in patients with primary hyperparathyroidism","volume":"36","year":"2012","journal-title":"World Journal of Surgery"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/BF03346273","article-title":"The effect of vitamin D status on the severity of bone disease and on the other features of primary hyperparathyroidism (pHPT) in a vitamin D deficient region","volume":"27","year":"2004","journal-title":"Journal of Endocrinological Investigation"},{"key":"ref451","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1007\/s00268-009-0377-8","article-title":"Vitamin D3 deficiency is associated with late-onset hypocalcemia after minimally invasive parathyroidectomy in a vitamin D borderline area.","volume":"34","year":"2010","journal-title":"World Journal of Surgery"},{"key":"ref281","first-page":"1","article-title":"Could we predict adenoma weight and postoperative serum calcium level with preoperative serum biochemical markers in patients with primary hyperparathyroidism?","volume":"16","year":"2007","journal-title":"Internet Journal of Surgery"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1210\/jc.2016-1099","article-title":"Association of hypoalbuminemia with osteoporosis: analysis of the national health and nutrition examination survey","volume":"101","year":"2016","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/ki.2009.522","article-title":"Testosterone increases urinary calcium excretion and inhibits expression of renal calcium transport proteins","volume":"77","year":"2010","journal-title":"Kidney International"},{"key":"ref591","doi-asserted-by":"crossref","first-page":"611","DOI":"10.7150\/ijms.4861","article-title":"Pre-operative serum alkaline phosphatase as a predictor for hypocalcemia post-parathyroid adenectomy","volume":"9","year":"2012","journal-title":"International Journal of Medical Sciences"},{"key":"ref461","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.surg.2005.09.018","article-title":"25-Hydroxyvitamin D deficiency is a risk factor for symptoms of postoperative hypocalcemia and secondary hyperparathyroidism after minimally invasive parathyroidectomy","volume":"138","year":"2005","journal-title":"Surgery"},{"key":"ref491","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1001\/jamasurg.2016.2310","article-title":"The American association of endocrine surgeons guidelines for definitive management of primary hyperparathyroidism","volume":"151","year":"2016","journal-title":"JAMA Surgery"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1177\/000313480407000204","article-title":"Post-parathyroidectomy hypocalcemia: incidence, risk factors, and management","volume":"70","year":"2004","journal-title":"American Surgeon"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/178\/1\/EJE-17-0416.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1530\/EJE-17-0416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T10:55:05Z","timestamp":1692960905000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/178\/1\/1\/6655373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":68,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/eje-17-0416","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]}}}