{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:48:56Z","timestamp":1789469336110,"version":"build-2803163510"},"reference-count":256,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>Heart failure is a major cause of morbidity and mortality in type 2 diabetes. Type 2 diabetes contributes to the development of heart failure through a variety of mechanisms, including disease-specific myocardial structural, functional and metabolic changes. This review will focus on the contemporary contributions of state of the art non-invasive technologies to our understanding of diabetic cardiomyopathy, including data on cardiac disease phenotype, cardiac energy metabolism and energetic deficiency, ectopic and visceral adiposity, diabetic liver disease, metabolic modulation strategies and cardiovascular outcomes with new classes of glucose-lowering therapies.<\/jats:p>","DOI":"10.1530\/eje-17-0724","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T10:43:56Z","timestamp":1518518636000},"page":"R127-R139","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":68,"title":["MECHANISMS IN ENDOCRINOLOGY: Diabetic cardiomyopathy: pathophysiology and potential metabolic interventions state of the art review"],"prefix":"10.1093","volume":"178","author":[{"given":"Eylem","family":"Levelt","sequence":"first","affiliation":[{"name":"1British Heart Foundation Cardiovascular Research Centre, University of Leicester, Glenfield Hospital, Leicester, UK"},{"name":"\u2020(E Levelt is now at Multidisciplinary Cardiovascular Research Centre and Biomedical Imaging Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Gulsin","sequence":"additional","affiliation":[{"name":"1British Heart Foundation Cardiovascular Research Centre, University of Leicester, Glenfield Hospital, Leicester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Neubauer","sequence":"additional","affiliation":[{"name":"2University of Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerry 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