{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:31:51Z","timestamp":1783488711032,"version":"3.55.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,5]]},"abstract":"\nObjective<\/jats:title>\nMaternal thyroid dysfunction during pregnancy is associated with neurodevelopmental impairment in the offspring. No data are currently available for the offspring of patients treated early for congenital hypothyroidism (CH). The aim of this study was to investigate motor and language milestones at one year of age in a population-based registry of children born to young women with CH.<\/jats:p>\n<\/jats:sec>\n\nDesign and methods<\/jats:title>\nWe assessed 110 children born to mothers with CH, and 1367 children from the EDEN French population-based birth cohort study prospectively, at the age of one year, with identical questionnaires. Outcomes were assessed in terms of scores for childhood developmental milestones relating to mobility, motor coordination, communication, motricity and language skills.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nAfter adjustment for confounding factors, children born to mothers with CH were found to have a higher risk of poor motor coordination than those of the EDEN cohort (OR: 4.18, 95% CI: 2.52\u20136.93). No differences were identified for the other four domains investigated. Children born to mothers with gestational diabetes have a higher risk of low motor coordination score than their peers (OR: 2.10, 95% CI: 1.21\u20133.66). Children born to mothers with TSH\u2009\u2265\u200910\u2009IU\/L during the first six months of pregnancy were more likely to have low motricity or communication skills scores than those born to mothers with lower TSH concentrations (56% vs 21% for each score, P<\/jats:italic>\u2009<\u20090.04).<\/jats:p>\n<\/jats:sec>\n\nConclusions<\/jats:title>\nMaternal CH may have slight adverse effects on some developmental milestones in the child at one year of age, particularly for children born to mothers with uncontrolled hypothyroidism. However, it remains unclear whether these adverse effects modify subsequent neurodevelopment.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/eje-17-0855","type":"journal-article","created":{"date-parts":[[2018,3,3]],"date-time":"2018-03-03T01:25:34Z","timestamp":1520040334000},"page":"471-480","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":8,"title":["Developmental milestones at one year for the offspring of mothers with congenital hypothyroidism: a population-based study"],"prefix":"10.1093","volume":"178","author":[{"given":"Juliane","family":"L\u00e9ger","sequence":"first","affiliation":[{"name":"1Paediatric Endocrinology Diabetology Department, Assistance Publique-H\u00f4pitaux de Paris, Robert Debr\u00e9 University Hospital, Reference Center for Growth and Development Endocrine Diseases, Paris, France"},{"name":"2Paris Diderot University, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"3Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), UMR 1141, DHU Protect, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Forhan","sequence":"additional","affiliation":[{"name":"4INSERM, UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cit\u00e9 Center, Early Origin of Child Health and Development Team (ORCHAD), Paris, France"},{"name":"5Paris Descartes University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Dos Santos","sequence":"additional","affiliation":[{"name":"1Paediatric Endocrinology Diabetology Department, Assistance Publique-H\u00f4pitaux de Paris, Robert Debr\u00e9 University Hospital, Reference Center for Growth and Development Endocrine Diseases, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Larroque","sequence":"additional","affiliation":[{"name":"6Epidemiology and Clinical Research Unit, Beaujon Hospital, Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Ecosse","sequence":"additional","affiliation":[{"name":"1Paediatric Endocrinology Diabetology Department, Assistance Publique-H\u00f4pitaux de Paris, Robert Debr\u00e9 University Hospital, Reference Center for Growth and Development Endocrine Diseases, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Aline","family":"Charles","sequence":"additional","affiliation":[{"name":"4INSERM, UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cit\u00e9 Center, Early Origin of Child Health and Development Team (ORCHAD), Paris, France"},{"name":"5Paris Descartes University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Heude","sequence":"additional","affiliation":[{"name":"4INSERM, UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cit\u00e9 Center, Early Origin of Child Health and Development Team (ORCHAD), Paris, 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