{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T23:22:05Z","timestamp":1772580125164,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Chronic excess of growth hormone (GH) often leads to systemic complications. The reversibility of these complications after GH resolution is not fully understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate when and to what extent will the comorbidities be ameliorated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>We conducted a prospective study comprising 24 patients with acromegaly, who achieved remission after transsphenoidal surgery. The dynamic changes of endocrine, cardiovascular, respiratory, sleep, bone and morphology parameters were evaluated at enrollment and 1 week, 1 month, 3 months, 6 months and 12 months after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Random GH dropped by 98.4% at the first day postoperatively. IGF-I index dropped by 50% and 64% at 1 week and 1 month respectively and remained unchanged onwards. Glucose metabolism improved significantly at 1 week and stabilized at 1 month. Testosterone in male patients recovered to normal range since 1 month. Systolic blood pressures dropped markedly at 3 months while diastolic blood pressures fell mildly at later visits. Abnormal lung function showed no improvement. The decrease of bone formation and resorption markers occurred at 1 week and 3 months, respectively. At 1 month, the tongue area declined while the airway volume increased significantly, accompanied with improved obstructive sleep apnea syndrome. Extremities, lips and nasal ala became smaller since 1 week. Liver, kidney and spleen volumes declined by 6.4, 15.9, 9.2%, respectively at 1 month. The volumes of pancreas and adrenal showed no change.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The rapid resolution of excessive GH led to the reversible changes of systemic comorbidities in a time-dependent and organ-specific manner.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/eje-17-0872","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T20:30:24Z","timestamp":1517430624000},"page":"365-375","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":16,"title":["The comprehensive impact on human body induced by resolution of growth hormone excess"],"prefix":"10.1093","volume":"178","author":[{"given":"Zhaoyun","family":"Zhang","sequence":"first","affiliation":[{"name":"1Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"},{"name":"2Shanghai Pituitary Tumor Center, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Li","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"},{"name":"2Shanghai Pituitary Tumor Center, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqiang","family":"He","sequence":"additional","affiliation":[{"name":"2Shanghai Pituitary Tumor Center, Shanghai, China"},{"name":"3Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijia","family":"Qiu","sequence":"additional","affiliation":[{"name":"2Shanghai Pituitary Tumor Center, Shanghai, China"},{"name":"3Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongying","family":"Ye","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"},{"name":"2Shanghai Pituitary Tumor Center, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongfei","family":"Wang","sequence":"additional","affiliation":[{"name":"2Shanghai Pituitary Tumor Center, Shanghai, China"},{"name":"3Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Shen","sequence":"additional","affiliation":[{"name":"2Shanghai Pituitary Tumor Center, Shanghai, China"},{"name":"3Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"He","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"},{"name":"2Shanghai Pituitary Tumor Center, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifei","family":"Yu","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"},{"name":"2Shanghai Pituitary Tumor Center, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefei","family":"Shou","sequence":"additional","affiliation":[{"name":"2Shanghai Pituitary Tumor Center, Shanghai, China"},{"name":"3Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanxin","family":"Huang","sequence":"additional","affiliation":[{"name":"4Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Yu","sequence":"additional","affiliation":[{"name":"5Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqian","family":"Huang","sequence":"additional","affiliation":[{"name":"6Department of Echocardiography, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijun","family":"Tang","sequence":"additional","affiliation":[{"name":"7Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daoying","family":"Geng","sequence":"additional","affiliation":[{"name":"7Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaowei","family":"Fu","sequence":"additional","affiliation":[{"name":"8Department of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congjin","family":"Liu","sequence":"additional","affiliation":[{"name":"9Department of Nuclear Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengyi","family":"Ma","sequence":"additional","affiliation":[{"name":"2Shanghai Pituitary Tumor Center, Shanghai, China"},{"name":"3Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Ye","sequence":"additional","affiliation":[{"name":"2Shanghai Pituitary Tumor Center, Shanghai, China"},{"name":"3Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qilin","family":"Zhang","sequence":"additional","affiliation":[{"name":"2Shanghai Pituitary Tumor Center, Shanghai, China"},{"name":"3Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichao","family":"Zhang","sequence":"additional","affiliation":[{"name":"2Shanghai Pituitary Tumor Center, Shanghai, China"},{"name":"3Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Shen","sequence":"additional","affiliation":[{"name":"2Shanghai Pituitary Tumor Center, Shanghai, China"},{"name":"3Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeping","family":"Yang","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"},{"name":"2Shanghai Pituitary Tumor Center, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"},{"name":"2Shanghai Pituitary Tumor Center, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingdang","family":"Liu","sequence":"additional","affiliation":[{"name":"9Department of Nuclear Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Lu","sequence":"additional","affiliation":[{"name":"9Department of Nuclear Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renming","family":"Hu","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"},{"name":"2Shanghai Pituitary Tumor Center, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Mao","sequence":"additional","affiliation":[{"name":"2Shanghai Pituitary Tumor Center, Shanghai, 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